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  • Thomopoulos, Thomas PDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine (author)

Prelabor cesarean delivery and early-onset acute childhood leukemia risk.

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-260945
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-260945URI
  • https://doi.org/10.1097/CEJ.0000000000000151DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The long-term impact of cesarean delivery (CD) on the health of the offspring is being explored methodically. We sought to investigate the effect of birth by (a) prelabor and (b) during-labor CD on the risk of early-onset (≤3 years) acute lymphoblastic leukemia (ALL), specifically of its prevailing precursor B (B-ALL) subtype. A total of 1099 incident cases of ALL (957 B-ALL), 131 of acute myeloid leukemia (AML), and their 1 : 1 age-matched and sex-matched controls, derived from the Nationwide Registry for Childhood Hematological Malignancies (1996-2013), were analyzed using multivariate regression models. A null association was found between prelabor and/or during labor CD and either ALL (B-ALL) or AML in the 0-14 age range. By contrast, birth by CD increased significantly the risk of early-onset ALL [odds ratioCD (ORCD)=1.57, 95% confidence interval (CI): 1.10-2.24] mainly on account of prelabor CD (ORprelaborCD=1.66, 95% CI: 1.13-2.43). The respective figures were even higher for the early-onset precursor B-ALL (ORCD=1.66, 95% CI: 1.15-2.40 and ORprelaborCD=1.79, 95% CI: 1.21-2.66), whereas no association emerged for early-onset AML. Prelabor CD, which deprives exposure of the fetus/infant to the presumably beneficial effect of stress hormones released in both vaginal labor and during labor CD, was associated exclusively with an increased risk of early-onset ALL, particularly the precursor B-ALL subtype. If confirmed, these adverse long-term outcomes of CD may point to re-evaluation of prelabor CD practices and prompt scientific discussion on the best ways to simulate the effects of vaginal delivery, such as a precesarean induction of labor.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Skalkidou, Alkistis,1977-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Reproduktiv hälsa/Sundström Poromaa(Swepub:uu)alksk607 (author)
  • Dessypris, NickDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine (author)
  • Chrousos, GeorgeFirst Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, School of Medicine, University of Athens (author)
  • Karalexi, Maria ADepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine (author)
  • Karavasilis, Theodoros GDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine (author)
  • Baka, MargaritaDepartment of Pediatric HematologyOncology, ‘Pan. & Agl. Kyriakou’ Children’s Hospital (author)
  • Hatzipantelis, EmmanuelSecond Department of Pediatrics, AHEPA General Hospital, Aristotelion University of Thessalonik (author)
  • Kourti, MariaDepartment of Pediatric Hematology and Oncology, Hippokration Hospital, Thessalonik (author)
  • Polychronopoulou, SophiaDepartment of Pediatric Haematology-Oncology, ‘Aghia Sophia’ Children’s Hospital (author)
  • Sidi, VasilikiDepartment of Pediatric Hematology and Oncology, Hippokration Hospital, Thessaloniki (author)
  • Stiakaki, EftichiaDepartment of Pediatric HematologyOncology, University Hospital of Heraklion, Greece (author)
  • Moschovi, MariaHaematologyOncology Unit, First Department of Pediatrics, Athens University Medical School, ‘Aghia Sophia’ Children’s Hospital (author)
  • Loutradis, DimitriosFirst Department of Obstetrics and Gynecology, ‘Alexandra’ Hospital, School of Medicine, University of Athens (author)
  • Petridou, Eleni ThDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine (author)
  • Department of Hygiene, Epidemiology and Medical Statistics, School of MedicineInstitutionen för kvinnors och barns hälsa (creator_code:org_t)

Related titles

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