WFRF:(Hamad Osama A.)
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- Barbu, AndreeaUppsala universitet,Klinisk immunologi,Uppsala University (author)
The role of complement factor C3 in lipid metabolism
- Article/chapterEnglish2015
Publisher, publication year, extent ...
- Elsevier BV,2015
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-261039
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-261039URI
- https://doi.org/10.1016/j.molimm.2015.02.027DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-40423URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Abundant reports have shown that there is a strong relationship between C3 and C3a-desArg levels, adipose tissue, and risk factors for cardiovascular disease, metabolic syndrome and diabetes. The data indicate that complement components, particularly C3, are involved in lipid metabolism. The C3 fragment, C3a-desArg, functions as a hormone that has insulin-like effects and facilitates triglyceride metabolism. Adipose tissue produces and regulates the levels of complement components, which promotes generation of inflammatory initiators such as the anaphylatoxins C3a and C5a. The anaphylatoxins trigger a cyto/chemokine response in proportion to the amount of adipose tissue present, and induce inflammation and mediate metabolic effects such as insulin resistance. These observations support the concept that complement is an important participant in lipid metabolism and in obesity, contributing to the metabolic syndrome and to the low-grade inflammation associated with obesity.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
- NATURVETENSKAP Biologi Immunologi hsv//swe
- NATURAL SCIENCES Biological Sciences Immunology hsv//eng
- C3
- C3a-desArg
- Obesity
- Metabolic syndrome (MetS)
- Apolipoproteins
- Immunologi
Added entries (persons, corporate bodies, meetings, titles ...)
- Hamad, Osama A.Uppsala universitet,Klinisk immunologi,Uppsala University(Swepub:uu)osaha535 (author)
- Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi,Uppsala University(Swepub:uu)larslind (author)
- Ekdahl, Kristina NilssonUppsala universitet,Klinisk immunologi,Uppsala University,Linnaeus Ctr Biomat Chem, BMC(Swepub:lnu)nnikr (author)
- Nilsson, BoUppsala universitet,Klinisk immunologi,Uppsala University(Swepub:uu)bonils (author)
- Uppsala universitetKlinisk immunologi (creator_code:org_t)
Related titles
- In:Molecular Immunology: Elsevier BV67:1, s. 101-1070161-58901872-9142
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