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Exploring microbial...
Exploring microbial dark matter to resolve the deep archaeal ancestry of eukaryotes
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- Saw, Jimmy H. (författare)
- Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab
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- Spang, Anja (författare)
- Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab
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- Zaremba-Niedzwiedzka, Katarzyna (författare)
- Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab
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- Juzokaite, Lina (författare)
- Uppsala universitet,Molekylär evolution,Uppsala Univ, Dept Cell & Mol Biol, Sci Life Lab, Uppsala, Sweden.
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- Dodsworth, Jeremy A. (författare)
- Univ Nevada, Sch Life Sci, Las Vegas, NV 89154 USA.
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- Murugapiran, Senthil K. (författare)
- Univ Nevada, Sch Life Sci, Las Vegas, NV 89154 USA.
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- Colman, Dan R. (författare)
- Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA.
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- Takacs-Vesbach, Cristina (författare)
- Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA.
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- Hedlund, Brian P. (författare)
- Univ Nevada, Sch Life Sci, Las Vegas, NV 89154 USA.
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- Guy, Lionel, 1980- (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Guy
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- Ettema, Thijs J. G. (författare)
- Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2015-09-26
- 2015
- Engelska.
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Ingår i: Philosophical Transactions of the Royal Society of London. Biological Sciences. - : The Royal Society. - 0962-8436 .- 1471-2970. ; 370:1678
- Relaterad länk:
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https://royalsociety...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The origin of eukaryotes represents an enigmatic puzzle, which is still lacking a number of essential pieces. Whereas it is currently accepted that the process of eukaryogenesis involved an interplay between a host cell and an alphaproteo-bacterial endosymbiont, we currently lack detailed information regarding the identity and nature of these players. A number of studies have provided increasing support for the emergence of the eukaryotic host cell from within the archaeal domain of life, displaying a specific affiliation with the archaeal TACK superphylum. Recent studies have shown that genomic exploration of yet-uncultivated archaea, the so-called archaeal 'dark matter', is able to provide unprecedented insights into the process of eukaryogenesis. Here, we provide an overview of state-of-the-art cultivation-independent approaches, and demonstrate how these methods were used to obtain draft genome sequences of several novel members of the TACK superphylum, including Lokiarchaeum, two representatives of the Miscellaneous Crenarchaeotal Group (Bathyarchaeota), and a Korarchaeum-related lineage. The maturation of cultivation-independent genomics approaches, as well as future developments in next-generation sequencing technologies, will revolutionize our current view of microbial evolution and diversity, and provide profound new insights into the early evolution of life, including the enigmatic origin of the eukaryotic cell.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- Archaea
- eukaryogenesis
- metagenomics
- microbial diversity
- single-cell genomics
- tree of life
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Saw, Jimmy H.
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Spang, Anja
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Zaremba-Niedzwie ...
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Juzokaite, Lina
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Dodsworth, Jerem ...
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Murugapiran, Sen ...
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visa fler...
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Colman, Dan R.
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Takacs-Vesbach, ...
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Hedlund, Brian P ...
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Guy, Lionel, 198 ...
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Ettema, Thijs J. ...
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Uppsala universitet