Search: id:"swepub:oai:DiVA.org:uu-264322" >
p73 is required for...
p73 is required for endothelial cell differentiation, migration and the formation of vascular networks regulating VEGF and TGF beta signaling
-
- Fernandez-Alonso, R. (author)
- Univ Leon, Dept Biol Mol, Inst Biomed IBIOMED, E-24071 Leon, Spain.
-
- Martin-Lopez, M. (author)
- Univ Leon, Dept Biol Mol, Inst Biomed IBIOMED, E-24071 Leon, Spain.
-
- Gonzalez-Cano, L. (author)
- Univ Leon, Dept Biol Mol, Inst Biomed IBIOMED, E-24071 Leon, Spain.
-
show more...
-
- Garcia, S. (author)
- Univ Leon, Dept Biol Mol, Inst Biomed IBIOMED, E-24071 Leon, Spain.
-
- Castrillo, F. (author)
- Univ Leon, Dept Biol Mol, Inst Biomed IBIOMED, E-24071 Leon, Spain.
-
- Diez-Prieto, I. (author)
- Univ Leon, Dept Biol Mol, Inst Biomed IBIOMED, E-24071 Leon, Spain.;Univ Leon, Dept Med Cirugia & Anat Vet, E-24071 Leon, Spain.
-
- Fernandez-Corona, A. (author)
- Univ Leon, Dept Biol Mol, Inst Biomed IBIOMED, E-24071 Leon, Spain.;Complejo Hosp Leon, Leon 24071, Spain.
-
- Lorenzo-Marcos, M. E. (author)
- Univ Leon, Dept Biol Mol, Inst Biomed IBIOMED, E-24071 Leon, Spain.;Complejo Hosp Leon, Leon 24071, Spain.
-
- Li, Xiujuan (author)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab
-
- Claesson-Welsh, Lena (author)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, S-75185 Uppsala, Sweden.;Uppsala Univ, Dept Immunol Genet & Pathol, Sci Life Lab, S-75185 Uppsala, Sweden.
-
- Marques, M. (author)
- Univ Leon, Inst Desarrollo Ganadero, E-24071 Leon, Spain.
-
- Marin, M. C. (author)
- Univ Leon, Dept Biol Mol, Inst Biomed IBIOMED, E-24071 Leon, Spain.
-
show less...
-
Univ Leon, Dept Biol Mol, Inst Biomed IBIOMED, E-24071 Leon, Spain Univ Leon, Dept Biol Mol, Inst Biomed IBIOMED, E-24071 Leon, Spain.;Univ Leon, Dept Med Cirugia & Anat Vet, E-24071 Leon, Spain. (creator_code:org_t)
- 2015-01-09
- 2015
- English.
-
In: Cell Death and Differentiation. - : Springer Science and Business Media LLC. - 1350-9047 .- 1476-5403. ; 22:8, s. 1287-
- Related links:
-
https://www.nature.c...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Vasculogenesis, the establishment of the vascular plexus and angiogenesis, branching of new vessels from the preexisting vasculature, involves coordinated endothelial differentiation, proliferation and migration. Disturbances in these coordinated processes may accompany diseases such as cancer. We hypothesized that the p53 family member p73, which regulates cell differentiation in several contexts, may be important in vascular development. We demonstrate that p73 deficiency perturbed vascular development in the mouse retina, decreasing vascular branching, density and stability. Furthermore, p73 deficiency could affect non endothelial cells (ECs) resulting in reduced in vivo proangiogenic milieu. Moreover, p73 functional inhibition, as well as p73 deficiency, hindered vessel sprouting, tubulogenesis and the assembly of vascular structures in mouse embryonic stem cell and induced pluripotent stem cell cultures. Therefore, p73 is necessary for EC biology and vasculogenesis and, in particular, that DNp73 regulates EC migration and tube formation capacity by regulation of expression of pro-angiogenic factors such as transforming growth factor-beta and vascular endothelial growth factors. DNp73 expression is upregulated in the tumor environment, resulting in enhanced angiogenic potential of B16-F10 melanoma cells. Our results demonstrate, by the first time, that differential p73-isoform regulation is necessary for physiological vasculogenesis and angiogenesis and DNp73 overexpression becomes a positive advantage for tumor progression due to its pro-angiogenic capacity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Fernandez-Alonso ...
-
Martin-Lopez, M.
-
Gonzalez-Cano, L ...
-
Garcia, S.
-
Castrillo, F.
-
Diez-Prieto, I.
-
show more...
-
Fernandez-Corona ...
-
Lorenzo-Marcos, ...
-
Li, Xiujuan
-
Claesson-Welsh, ...
-
Marques, M.
-
Marin, M. C.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Medical Biotechn ...
-
and Medical Biotechn ...
- Articles in the publication
-
Cell Death and D ...
- By the university
-
Uppsala University