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hsv:(MEDICAL AND HEALTH SCIENCES) hsv:(Clinical Medicine) hsv:(Hematology)
 

Sökning: hsv:(MEDICAL AND HEALTH SCIENCES) hsv:(Clinical Medicine) hsv:(Hematology) > Different Procoagul...

  • Moll, GuidoKarolinska Institutet,Charite, Nephrol & Intens Care Med, D-13353 Berlin, Germany.;Berlin Brandenburg Sch Regenerat Therapies BSRT, Berlin, Germany.;Karolinska Inst, Lab Med, Stockholm, Sweden. (författare)

Different Procoagulant Activity of Therapeutic Mesenchymal Stromal Cells Derived from Bone Marrow and Placental Decidua

  • Artikel/kapitelEngelska2015

Förlag, utgivningsår, omfång ...

  • Mary Ann Liebert Inc,2015
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-264617
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-264617URI
  • https://doi.org/10.1089/scd.2015.0120DOI
  • https://lup.lub.lu.se/record/7733195URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:132026464URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-269149URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:132280024URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Meeting Abstract: P139
  • While therapeutic mesenchymal stromal/stem cells (MSCs) have usually been obtained from bone marrow, perinatal tissues have emerged as promising new sources of cells for stromal cell therapy. In this study, we present a first safety follow-up on our clinical experience with placenta-derived decidual stromal cells (DSCs), used as supportive immunomodulatory and regenerative therapy for patients with severe complications after allogeneic hematopoietic stem cell transplantation (HSCT). We found that DSCs are smaller, almost half the volume of MSCs, which may favor microvascular passage. DSCs also show different hemocompatibility, with increased triggering of the clotting cascade after exposure to human blood and plasma in vitro. After infusion of DSCs in HSCT patients, we observed a weak activation of the fibrinolytic system, but the other blood activation markers remained stable, excluding major adverse events. Expression profiling identified differential levels of key factors implicated in regulation of hemostasis, such as a lack of prostacyclin synthase and increased tissue factor expression in DSCs, suggesting that these cells have intrinsic blood-activating properties. The stronger triggering of the clotting cascade by DSCs could be antagonized by optimizing the cell graft reconstitution before infusion, for example, by use of low-dose heparin anticoagulant in the cell infusion buffer. We conclude that DSCs are smaller and have stronger hemostatic properties than MSCs, thus triggering stronger activation of the clotting system, which can be antagonized by optimizing the cell graft preparation before infusion. Our results highlight the importance of hemocompatibility safety testing for every novel cell therapy product before clinical use, when applied using systemic delivery.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ignatowicz, LechLund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Sci, Lund, Sweden.(Swepub:lu)med-lio (författare)
  • Catar, RusanCharite, Dept Nephrol & Intens Care Med, D-13353 Berlin, Germany. (författare)
  • Luecht, ChristianCharite, Dept Nephrol & Intens Care Med, D-13353 Berlin, Germany. (författare)
  • Sadeghi, BehnamKarolinska Institutet,Karolinska Inst, Lab Med, Stockholm, Sweden. (författare)
  • Hamad, OsamaUppsala universitet,Institutionen för immunologi, genetik och patologi (författare)
  • Jungebluth, PhilippKarolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Adv Ctr Translat Regenerat Med ACTREM, Stockholm, Sweden.;Heidelberg Univ, Dept Thorac Surg, Thoraxklin, Heidelberg, Germany. (författare)
  • Dragun, DuskaCharite, Berlin Brandenburg Sch Regenerat Therapies BSRT, D-13353 Berlin, Germany.;Charite, Dept Nephrol & Intens Care Med, D-13353 Berlin, Germany. (författare)
  • Schmidtchen, ArturLund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Sci, Lund, Sweden.(Swepub:lu)derm-asc (författare)
  • Ringden, OlleKarolinska Institutet,Karolinska Inst, Lab Med, Stockholm, Sweden. (författare)
  • Karolinska InstitutetCharite, Nephrol & Intens Care Med, D-13353 Berlin, Germany.;Berlin Brandenburg Sch Regenerat Therapies BSRT, Berlin, Germany.;Karolinska Inst, Lab Med, Stockholm, Sweden. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Stem Cells and Development: Mary Ann Liebert Inc28:S2, s. 50-511547-32871557-8534
  • Ingår i:Transplant International: Mary Ann Liebert Inc28:S2, s. 50-510934-08741432-2277

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