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Baseline data of pa...
Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative : an individual patient data meta-analysis
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- Abdulla, Salim (författare)
- Ifakara Hlth Inst, Dar Es Salaam, Tanzania.
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- Ashley, Elizabeth A. (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;Mahidol Univ, Mahidol Oxford Trop Med Res Unit MORU, Fac Trop Med, Bangkok 10700, Thailand.
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- Bassat, Quique (författare)
- Univ Barcelona, Ctr Invest Saude Manhica Manhica Mozamb & ISGloba, Barcelona Ctr Int Hlth Res CRESIB, Hosp Clin, Barcelona, Spain.
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visa fler...
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- Bethell, Delia (författare)
- AFRIMS, Dept Immunol & Med, Bangkok, Thailand.
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- Bjorkman, Anders (författare)
- Karolinska Institutet
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- Borrmann, Steffen (författare)
- Kenya Govt Med Res Ctr, Wellcome Trust Res Programme, Kilifi, Kenya.;Univ Magdeburg, Sch Med, D-39106 Magdeburg, Germany.
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- D'Alessandro, Umberto (författare)
- Inst Trop Med, Unit Malariol, B-2000 Antwerp, Belgium.;MRC Unit, Fajara, Gambia.
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- Dahal, Prabin (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;WorldWide Antimalarial Resistance Network WWARN, Oxford, England.
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- Day, Nicholas P. (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;Mahidol Univ, Mahidol Oxford Trop Med Res Unit MORU, Fac Trop Med, Bangkok 10700, Thailand.
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- Diakite, Mahamadou (författare)
- Univ Bamako, Malaria Res & Training Ctr, Bamako, Mali.
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Djimde, Abdoulaye A. (författare)
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- Dondorp, Arjen M. (författare)
- Karolinska Institutet
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- Duong, Socheat (författare)
- Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia.
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Edstein, Michael D. (författare)
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- Fairhurst, Rick M. (författare)
- NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD USA.
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- Faiz, M. Abul (författare)
- Malaria Res Grp MRG & Dev Care Fdn, Dhaka, Bangladesh.
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- Falade, Catherine (författare)
- Univ Ibadan, Coll Med, Ibadan, Nigeria.
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- Flegg, Jennifer A. (författare)
- Monash Univ, Sch Math Sci, Clayton, Vic 3800, Australia.
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- Fogg, Carole (författare)
- Univ Portsmouth, Portsmouth, Hants, England.
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- Gonzalez, Raquel (författare)
- Ctr Invest Saude Manhica Manhica Mozamb, Barcelona, Spain.;CRESIB, Barcelona, Spain.
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- Greenwood, Brian (författare)
- London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London WC1, England.
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- Guerin, Philippe J. (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;WorldWide Antimalarial Resistance Network WWARN, Oxford, England.
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- Guthmann, Jean-Paul (författare)
- Epicentre, Paris, France.
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- Hamed, Kamal (författare)
- Novartis Pharmaceut, E Hanover, NJ USA.
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Hien, Tran Tinh (författare)
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- Htut, Ye (författare)
- Dept Med Res, Lower Myanmar, Yangon, Myanmar.
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- Juma, Elizabeth (författare)
- Kenya Govt Med Res Ctr, Nairobi, Kenya.
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- Lim, Pharath (författare)
- NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD USA.;US & Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia.
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- Mårtensson, Andreas (författare)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Microbiol Cell & Tumour Biol, Dept Publ Hlth Sci, Malaria Res, Stockholm, Sweden.
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- Mayxay, Mayfong (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;Mahosot Hosp, Lao Oxford Mahosot Hosp, Wellcome Trust Res Unit LOMWRU, Viangchan, Laos.;Univ Hlth Sci, Fac Postgrad Studies, Viangchan, Laos.
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- Mokuolu, Olugbenga A. (författare)
- Univ Ilorin, Dept Paediat & Child Hlth, Ilorin, Nigeria.
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- Moreira, Clarissa (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;WorldWide Antimalarial Resistance Network WWARN, Oxford, England.
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- Newton, Paul (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;Mahosot Hosp, Lao Oxford Mahosot Hosp, Wellcome Trust Res Unit LOMWRU, Viangchan, Laos.
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- Noedl, Harald (författare)
- Med Univ Vienna, Inst Specif Prophylaxis & Trop Med, Vienna, Austria.
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- Nosten, Francois (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;Mahidol Univ, Shoklo Malaria Res Unit, Mahidol Oxford Trop Med Res Unit, Fac Trop Med, Bangkok 10700, Thailand.
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- Ogutu, Bernhards R. (författare)
- Kenya Govt Med Res Ctr, US Army Med Res Unit, Kisumu, Kenya.
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- Onyamboko, Marie A. (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;Kinshasa Sch Publ Hlth, Kinshasa, DEM REP CONGO.
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- Owusu-Agyei, Seth (författare)
- Kintampo Hlth Res Ctr, Kintampo, Ghana.
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- Phyo, Aung Pyae (författare)
- Mahidol Univ, Shoklo Malaria Res Unit, Mahidol Oxford Trop Med Res Unit, Fac Trop Med, Bangkok 10700, Thailand.
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- Premji, Zul (författare)
- Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania.
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- Price, Ric N. (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;WorldWide Antimalarial Resistance Network WWARN, Oxford, England.;Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT, Australia.;Charles Darwin Univ, Darwin, NT 0909, Australia.
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- Pukrittayakamee, Sasithon (författare)
- Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand.
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- Ramharter, Michael (författare)
- Med Univ Vienna, Div Infect Dis & Trop Med, Dept Med 1, Vienna, Austria.;Univ Tubingen, Inst Tropenmed, Tubingen, Germany.;Ctr Rech Med Lambarene, Lambarene, Gabon.
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- Sagara, Issaka (författare)
- Univ Bamako, Fac Med Pharm & Odontostomatol, Dept Epidemiol Parasit Dis, Malaria Res & Training Ctr, Bamako, Mali.
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- Se, Youry (författare)
- AFRIMS, Phnom Penh, Cambodia.
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- Suon, Seila (författare)
- Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia.
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- Stepniewska, Kasia (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;WorldWide Antimalarial Resistance Network WWARN, Oxford, England.
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- Ward, Stephen A. (författare)
- Univ Liverpool, Liverpool Sch Trop Med, Dept Parasitol, Liverpool L3 5QA, Merseyside, England.
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- White, Nicholas J. (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;Mahidol Univ, Mahidol Oxford Trop Med Res Unit MORU, Fac Trop Med, Bangkok 10700, Thailand.
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- Winstanley, Peter A. (författare)
- Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England.
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Ifakara Hlth Inst, Dar Es Salaam, Tanzania Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;Mahidol Univ, Mahidol Oxford Trop Med Res Unit MORU, Fac Trop Med, Bangkok 10700, Thailand. (creator_code:org_t)
- 2015-09-22
- 2015
- Engelska.
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Ingår i: Malaria Journal. - : Springer Science and Business Media LLC. - 1475-2875. ; 14
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://malariajourn...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Artemisinin resistance in Plasmodium falciparum manifests as slow parasite clearance but this measure is also influenced by host immunity, initial parasite biomass and partner drug efficacy. This study collated data from clinical trials of artemisinin derivatives in falciparum malaria with frequent parasite counts to provide reference parasite clearance estimates stratified by location, treatment and time, to examine host factors affecting parasite clearance, and to assess the relationships between parasite clearance and risk of recrudescence during follow-up. Methods: Data from 24 studies, conducted from 1996 to 2013, with frequent parasite counts were pooled. Parasite clearance half-life (PC1/2) was estimated using the WWARN Parasite Clearance Estimator. Random effects regression models accounting for study and site heterogeneity were used to explore factors affecting PC1/2 and risk of recrudescence within areas with reported delayed parasite clearance (western Cambodia, western Thailand after 2000, southern Vietnam, southern Myanmar) and in all other areas where parasite populations are artemisinin sensitive. Results: PC1/2 was estimated in 6975 patients, 3288 of whom also had treatment outcomes evaluate d during 28-63 days follow-up, with 93 (2.8 %) PCR-confirmed recrudescences. In areas with artemisinin-sensitive parasites, the median PC1/2 following three-day artesunate treatment (4 mg/kg/day) ranged from 1.8 to 3.0 h and the proportion of patients with PC1/2 > 5 h from 0 to 10 %. Artesunate doses of 4 mg/kg/day decreased PC1/2 by 8.1 % (95 % CI 3.2-12.6) compared to 2 mg/kg/day, except in populations with delayed parasite clearance. PC1/2 was longer in children and in patients with fever or anaemia at enrolment. Long PC1/2 (HR = 2.91, 95 % CI 1.95-4.34 for twofold increase, p < 0.001) and high initial parasitaemia (HR = 2.23, 95 % CI 1.44-3.45 for tenfold increase, p < 0.001) were associated independently with an increased risk of recrudescence. In western Cambodia, the region with the highest prevalence of artemisinin resistance, there was no evidence for increasing PC1/2 since 2007. Conclusions: Several factors affect PC1/2. As substantial heterogeneity in parasite clearance exists between locations, early detection of artemisinin resistance requires reference PC1/2 data. Studies with frequent parasite count measurements to characterize PC1/2 should be encouraged. In western Cambodia, where PC1/2 values are longest, there is no evidence for recent emergence of higher levels of artemisinin resistance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Samhällsfarmaci och klinisk farmaci (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Social and Clinical Pharmacy (hsv//eng)
Nyckelord
- Malaria
- Parasite clearance
- Artemisinin resistance
- Drug resistance
- Plasmodium falciparum
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Abdulla, Salim
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Ashley, Elizabet ...
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Bassat, Quique
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Bethell, Delia
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Bjorkman, Anders
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Borrmann, Steffe ...
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visa fler...
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D'Alessandro, Um ...
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Dahal, Prabin
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Day, Nicholas P.
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Diakite, Mahamad ...
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Djimde, Abdoulay ...
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Dondorp, Arjen M ...
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Duong, Socheat
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Edstein, Michael ...
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Fairhurst, Rick ...
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Faiz, M. Abul
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Falade, Catherin ...
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Flegg, Jennifer ...
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Fogg, Carole
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Gonzalez, Raquel
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Greenwood, Brian
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Guerin, Philippe ...
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Guthmann, Jean-P ...
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Hamed, Kamal
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Hien, Tran Tinh
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Htut, Ye
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Juma, Elizabeth
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Lim, Pharath
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Mårtensson, Andr ...
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Mayxay, Mayfong
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Mokuolu, Olugben ...
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Moreira, Clariss ...
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Newton, Paul
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Noedl, Harald
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Nosten, Francois
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Ogutu, Bernhards ...
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Onyamboko, Marie ...
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Owusu-Agyei, Set ...
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Phyo, Aung Pyae
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Premji, Zul
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Price, Ric N.
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Pukrittayakamee, ...
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Ramharter, Micha ...
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Sagara, Issaka
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Se, Youry
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Suon, Seila
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Stepniewska, Kas ...
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Ward, Stephen A.
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White, Nicholas ...
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Winstanley, Pete ...
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