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Harms, Hendrik J
(author)
Quantification of [(11)C]-meta-hydroxyephedrine uptake in human myocardium
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-09-26
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Springer Science and Business Media LLC,2014
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-265004
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265004URI
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https://doi.org/10.1186/s13550-014-0052-4DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: The aims of this study were to determine the optimal tracer kinetic model for [(11)C]-meta-hydroxyephedrine ([(11)C]HED) and to evaluate the performance of several simplified methods.METHODS: Thirty patients underwent dynamic 60-min [(11)C]HED scans with online arterial blood sampling. Single-tissue and both reversible and irreversible two-tissue models were fitted to the data using the metabolite-corrected arterial input function. For each model, reliable fits were defined as those yielding outcome parameters with a coefficient of variation (CoV) <25%. The optimal model was determined using Akaike and Schwarz criteria and the F-test, together with the number of reliable fits. Simulations were performed to study accuracy and precision of each model. Finally, quantitative results obtained using a population-averaged metabolite correction were evaluated, and simplified retention index (RI) and standardized uptake value (SUV) results were compared with quantitative volume of distribution (V T) data.RESULTS: The reversible two-tissue model was preferred in 75.8% of all segments, based on the Akaike information criterion. However, V T derived using the single-tissue model correlated highly with that of the two-tissue model (r (2) = 0.94, intraclass correlation coefficient (ICC) = 0.96) and showed higher precision (CoV of 24.6% and 89.2% for single- and two-tissue models, respectively, at 20% noise). In addition, the single-tissue model yielded reliable fits in 94.6% of all segments as compared with 77.1% for the reversible two-tissue model. A population-averaged metabolite correction could not be used in approximately 20% of the patients because of large biases in V T. RI and SUV can provide misleading results because of non-linear relationships with V T.CONCLUSIONS: Although the reversible two-tissue model provided the best fits, the single-tissue model was more robust and results obtained were similar. Therefore, the single-tissue model was preferred. RI showed a non-linear correlation with V T, and therefore, care has to be taken when using RI as a quantitative measure.
Added entries (persons, corporate bodies, meetings, titles ...)
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de Haan, Stefan
(author)
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Knaapen, Paul
(author)
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Allaart, Cornelis P
(author)
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Rijnierse, Mischa T
(author)
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Schuit, Robert C
(author)
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Windhorst, Albert D
(author)
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Lammertsma, Adriaan A
(author)
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Huisman, Marc C
(author)
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Lubberink, MarkUppsala universitet,Enheten för nuklearmedicin och PET(Swepub:uu)marklubb
(author)
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Uppsala universitetEnheten för nuklearmedicin och PET
(creator_code:org_t)
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In:EJNMMI Research: Springer Science and Business Media LLC42191-219X
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Harms, Hendrik J
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de Haan, Stefan
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Knaapen, Paul
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Allaart, Corneli ...
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Rijnierse, Misch ...
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Schuit, Robert C
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Windhorst, Alber ...
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Huisman, Marc C
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Lubberink, Mark
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EJNMMI Research
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