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Regulation of Insta...
Regulation of Instant Blood Mediated Infl ammatoryReaction (IBMIR) in Pancreatic Islet Xeno-Transplantation : Points for Therapeutic Interventions
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Kourtzelis, Iannis (författare)
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- Magnusson, Peetra U. (författare)
- Uppsala universitet,Klinisk immunologi,Magnusson
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Kotlabova, Klara (författare)
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visa fler...
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Lambris, John D. (författare)
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Chavakis, Triantafyllos (författare)
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visa färre...
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(creator_code:org_t)
- Cham : Springer, 2015
- 2015
- Engelska.
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Ingår i: Immune Responses to Biosurfaces. - Cham : Springer. - 9783319186023 - 9783319186030 ; , s. 171-188
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Xeno-transplantation of pancreatic islets represents a promising therapeuticalternative for the treatment of type 1 diabetes mellitus. However, potentinnate immune responses induced shortly after the transplantation of donor islets tothe recipient, comprising the Instant Blood Mediated Immune Reaction (IBMIR),exert detrimental actions on islet graft function. The coagulation and complementcascades together with the leukocyte and platelet populations are the major playersin IBMIR. This innate immune attack affects dramatically islet integrity and leadsto signifi cant loss of function of the xenograft. In the present review, we focus on themechanisms contributing to IBMIR components and address therapeutic interventionapproaches to limit IBMIR by administering inhibitors in circulation, by coatingthe islet surface with inhibitors or by generating transgenic donor animals; theseapproaches could result in improved xenograft survival.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- kap (ämneskategori)
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