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- Biglarnia, Ali-RezaUppsala universitet,Institutionen för kirurgiska vetenskaper (author)
Complement Interception Across Humoral Incompatibility in Solid Organ Transplantation : A Clinical Perspective
- Article/chapterEnglish2015
Publisher, publication year, extent ...
- Cham :Springer International Publishing,2015
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-265645
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265645URI
- https://doi.org/10.1007/978-3-319-18603-0_13DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-40419URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- The humoral barrier in transplant biology is the result of preformed donor-specific antibodies (DSAs), directed either against human leukocyte antigens (HLA) or non-HLA antigens such as blood group (ABO) molecules. The term "sensitization" applies to patients carrying these antibodies. Transplantation is widely accepted as a life-saving opportunity for patients with terminal end-organ disease. However, in sensitized patients, transplant outcome is hampered by antibody-mediated rejection (AMR) as a consequence of DSA exposure. Furthermore, sensitized patients have limited access to "matched" organs from the both living and deceased donor pool. Considering the crucial role of the complement system in the pathophysiology of AMR and the availability of complement intervention therapeutics, there is a growing interest in complement-targeting strategies. This review highlights the emerging importance of monitoring and modulation of the complement system in the context of enabling transplantation across humoral incompatibility in sensitized recipients with preformed anti-HLA or natural anti-ABO antibodies. It also discusses the significance of the complement system in the induction of accommodation and further emphasizes current and future perspectives of novel complement therapeutics.
Subject headings and genre
- NATURVETENSKAP Biologi Immunologi hsv//swe
- NATURAL SCIENCES Biological Sciences Immunology hsv//eng
- ABO- and HLA-incompatibility
- Antibody-mediated rejection
- Terminal complement inhibition
- Transplantation
- Complement therapeutics
- Desensitization
- Immunologi
Added entries (persons, corporate bodies, meetings, titles ...)
- Nilsson, Kristina EkdahlUppsala universitet,Klinisk immunologi,Uppsala University,Linnaeus Ctr Biomat Chem, BMC(Swepub:lnu)nnikr (author)
- Nilsson, BoUppsala universitet,Klinisk immunologi,Uppsala University(Swepub:uu)bonils (author)
- Biglarnia, AlirezaUppsala University (author)
- Uppsala universitetInstitutionen för kirurgiska vetenskaper (creator_code:org_t)
Related titles
- In:IMMUNE RESPONSES TO BIOSURFACESCham : Springer International Publishing, s. 211-23397833191860309783319186023
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