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Association between...
Association between ongoing anti-C1q antibody production in peripheral blood and proliferative nephritis in patients with active systemic lupus erythematosus.
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- Gunnarsson, I (author)
- Karolinska Institutet
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- Rönnelid, Johan (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,KITM
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Huang, Y H (author)
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Rogberg, S (author)
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- Nilsson, B (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,KITM
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- Lundberg, I (author)
- Karolinska Institutet
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- Klareskog, L (author)
- Karolinska Institutet
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(creator_code:org_t)
- Oxford University Press (OUP), 1997
- 1997
- English.
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In: British Journal of Rheumatology. - : Oxford University Press (OUP). - 0263-7103 .- 1460-2172. ; 36, s. 32-
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The aim of this study was to compare ongoing production of anti-C1q antibodies (anti-C1q) in peripheral blood with serum anti-C1q levels in patients with systemic lupus erythematosus (SLE), especially in patients with nephritis. Using the ELISPOT technique for the detection of IgG and IgA anti-C1q production, 21 patients with active SLE were investigated. ELISAs for IgG and IgA anti-C1q were compared with the ELISPOT results. Six of the patients were found to have proliferative nephritis (WHO grade III/IV) confirmed by renal biopsy. High numbers of IgG anti-C1q spot-forming cells (SFC), defined as > 20/10(5) plated peripheral blood mononuclear cells (PBMC), were exclusively observed in patients with proliferative nephritis (P < 0.0001). Serum levels of IgG anti-C1q were significantly increased in patients with proliferative nephritis (P = 0.039). High ongoing IgG anti-C1q production was observed in all patients with proliferative nephritis, which may be a contributory factor in the pathogenesis of this disorder. The detection of IgG anti-C1q production may be valuable in the clinical investigation of patients with suspected SLE nephritis.
Publication and Content Type
- ref (subject category)
- art (subject category)
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