Serotonin-2 and dopamine-1 binding components of clozapine in frontal cortex and striatum in the human brain visualized by positron emission tomography

• The specific binding of IV-methyl-C-11-clozapine in the human brain was studied in five healthy volunteers with positron emission tomography (PET). Four of the volunteers were reexamined after treatment with the dopamine D-1 and D-2 receptor antagonist fl

Nyckelord

frontal cortex; striatum; clozapine; flupenthixol; ritanserin; serotonin(2); dopamine D-1; ANTIPSYCHOTIC-DRUGS; RECEPTOR-BINDING; SCHIZOPHRENIA; PET; HYPOTHESIS; OCCUPANCY; AFFINITY; SYSTEM; MONKEY; D2

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