Second allogeneic stem cell transplant for aplastic anaemia: a retrospective study by the severe aplastic anaemia working party of the European society for blood and marrow transplantation

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Cesaro, SimoneAzienda Osped Univ Integrata, Paediat Haematol & Oncol, Verona, Italy. (author)

Second allogeneic stem cell transplant for aplastic anaemia : a retrospective study by the severe aplastic anaemia working party of the European society for blood and marrow transplantation

Article/chapterEnglish2015

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2015-08-25
Wiley,2015
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LIBRIS-ID:oai:DiVA.org:uu-268411
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-268411URI
https://doi.org/10.1111/bjh.13650DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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We analysed the outcome of a second allogeneic haematopoietic stem cell transplant (alloHSCT) in 162 patients reported to the European Society for Blood and Marrow Transplantation between 1998 and 2009. Donor origin was a sibling in 110 and an unrelated donor in 52 transplants, respectively. The stem cell source was bone marrow in 31% and peripheral blood in 69% of transplants. The same donor as for the first alloHSCT was used in 81% of transplants whereas a change in the choice of stem cell source was reported in 56% of patients, mainly from bone marrow to peripheral blood. Neutrophil and platelet engraftment occurred in 85% and 72% of patients, after a median time of 15 and 17days, respectively. Grade II-IV acute graft-versus-host disease (GVHD) and chronic GVHD occurred in 21% and 37% of patients, respectively. Graft failure (GF) occurred in 42 patients (26%). After a median follow-up of 3.5years, the 5-year overall survival (OS) was 60.7%. In multivariate analysis, the only factor significantly associated with a better outcome was a Karnofsky/Lansky score 80 (higher OS). We conclude that a second alloHSCT is feasible rescue option for GF in SAA, with a successful outcome in 60% of cases.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Medicinsk bioteknologi hsv//swe
MEDICAL AND HEALTH SCIENCES Medical Biotechnology Medical Biotechnology hsv//eng
severe aplastic anaemia
haematopoietic stem cell transplantation
graft failure
rescue treatment
second allogeneic transplant

Added entries (persons, corporate bodies, meetings, titles ...)

de latour, Regis PeffaultUniv Paris 07, Dept Haematol, BMT, Hop St Louis, Paris, France. (author)
Tridello, GloriaAzienda Osped Univ Integrata, Paediat Haematol & Oncol, Verona, Italy. (author)
Pillon, MartaDipartimento Pediat, Clin Oncoematol Pediat, Padua, Italy. (author)
Carlson, KristinaUppsala universitet,Hematologi(Swepub:uu)krica965 (author)
Fagioli, FrancaRegina Margherita Hosp, Paediat Haematol, Turin, Italy. (author)
Jouet, Jean-PierreHop Claude Huriez Serv Malad Sang, Lille, France. (author)
Koh, Mickey B. C.St George Hosp, Dept Haematol, London, England. (author)
Panizzolo, Irene SaraAzienda Osped Univ Integrata, Paediat Haematol & Oncol, Verona, Italy. (author)
Kyrcz-Krzemien, SlawomiraMed Univ Silesia, Univ Dept Haematol, Katowice, Poland.;BMT, Katowice, Poland. (author)
Maertens, JohanUniv Hosp Gasthuisberg, Dept Haematol, Leuven, Belgium. (author)
Rambaldi, AlessandroOsped Riuniti Bergamo, Div Ematol, Bergamo, Italy. (author)
Strahm, BrigitteUniv Med Ctr, Dept Paediat & Adolescent Med, Paediat Haematol & Oncol, Freiburg, Germany. (author)
Blaise, DidierInst Paoli Calmettes, Ctr Rech Cancerol Marseille, Programme Transplantat & Therapie Cellulaire, Marseille, France. (author)
Maschan, AlexeiFed Res Ctr Paediat Haematol Oncol & Immunol, Moscow, Russia. (author)
Marsh, JudithKings Coll London, Kings Coll Hosp, Dept Haematol Med, London, England. (author)
Dufour, CarloInst G Gaslini, Paediat Haematol, Genoa, Italy. (author)
Azienda Osped Univ Integrata, Paediat Haematol & Oncol, Verona, Italy.Univ Paris 07, Dept Haematol, BMT, Hop St Louis, Paris, France. (creator_code:org_t)

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In:British Journal of Haematology: Wiley171:4, s. 606-6140007-10481365-2141

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

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