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Population genetic ...
Population genetic differentiation of height and body mass index across Europe
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- Robinson, Matthew R. (author)
- Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.
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- Hemani, Gibran (author)
- Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.
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- Medina-Gomez, Carolina (author)
- Erasmus Univ, Dept Internal Med, Med Ctr, Rotterdam, Netherlands.
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show more...
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- Mezzavilla, Massimo (author)
- Ist Ricovero & Cura Carattere Sci IRCCS, Inst Maternal & Child Hlth, Trieste, Italy.;Wellcome Trust Sanger Inst, Hinxton, Cambs, England.,Mental Hlth Devices Copenhagen, MHC Sct Hans, Inst Biol Psychiat, Roskilde, Denmark.;Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark.;Lundbeck Fdn Initiat Integrat Psychiat Res iPSYCH, Aarhus, Denmark.,Univ Exeter, Sch Med, Genet Complex Traits, Exeter, Devon, England.,Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.;Univ Queensland, Translat Res Inst, Diamantina Inst, Brisbane, Qld, Australia.
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- Esko-, Tonu (author)
- Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.;Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.;Broad Inst MIT & Harvard, Cambridge, MA USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA USA.
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- Shakhbazov, Konstantin (author)
- Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.
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- Powell, Joseph E. (author)
- Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.;Univ Queensland, Translat Res Inst, Diamantina Inst, Brisbane, Qld, Australia.
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- Vinkhuyzen, Anna (author)
- Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.
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- Berndt, Sonja I. (author)
- NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
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- Gustafsson, Stefan (author)
- Uppsala universitet,Molekylär epidemiologi
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- Justice, Anne E. (author)
- Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.
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- Kahali, Bratati (author)
- Univ Michigan, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA.;Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA.
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- Locke, Adam E. (author)
- Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
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- Pers, Tune H. (author)
- Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.;Broad Inst MIT & Harvard, Cambridge, MA USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA USA.;Tech Univ Denmark, Dept Syst Biol, Ctr Biol Sequence Anal, DK-2800 Lyngby, Denmark.
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- Vedantam, Sailaja (author)
- Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.;Broad Inst MIT & Harvard, Cambridge, MA USA.
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Wood, Andrew R. (author)
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- van Rheenen, Wouter (author)
- Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol & Neurosurg, Utrecht, Netherlands.
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- Andreassen, Ole A. (author)
- Univ Oslo, Oslo Univ Hosp, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway.
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- Gasparini, Paolo (author)
- Ist Ricovero & Cura Carattere Sci IRCCS, Inst Maternal & Child Hlth, Trieste, Italy.
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- Metspalu, Andres (author)
- Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.
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- van den Berg, Leonard H. (author)
- Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol & Neurosurg, Utrecht, Netherlands.
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- Veldink, Jan H. (author)
- Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol & Neurosurg, Utrecht, Netherlands.
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- Rivadeneira, Fernando (author)
- Erasmus Univ, Dept Internal Med, Med Ctr, Rotterdam, Netherlands.
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- Werge, Thomas M. (author)
- Mental Hlth Devices Copenhagen, MHC Sct Hans, Inst Biol Psychiat, Roskilde, Denmark.;Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark.;Lundbeck Fdn Initiat Integrat Psychiat Res iPSYCH, Aarhus, Denmark.
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- Abecasis, Goncalo R. (author)
- Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
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- Boomsma, Dorret I. (author)
- Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands.;Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.
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- Chasman, Daniel I. (author)
- Harvard Univ, Sch Med, Dept Genet, Boston, MA USA.;Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA.
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- de Geus, Eco J. C. (author)
- Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands.;Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.
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- Frayling, Timothy M. (author)
- Univ Exeter, Sch Med, Genet Complex Traits, Exeter, Devon, England.
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- Hirschhorn, Joel N. (author)
- Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.;Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.;Broad Inst MIT & Harvard, Cambridge, MA USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA USA.
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- Hottenga, Jouke Jan (author)
- Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands.;Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.
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- Ingelsson, Erik (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
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- Loos, Ruth J. F. (author)
- Univ Cambridge, Addenbrookes Hosp, Inst Metab Sci, MRC,Epidemiol Unit, Cambridge CB2 2QQ, England.;Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.
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- Magnusson, Patrik K. E. (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Martin, Nicholas G. (author)
- QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia.
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- Montgomery, Grant W. (author)
- QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia.
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- North, Kari E. (author)
- Univ Michigan, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA.;Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA.;Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC USA.
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- Pedersen, Nancy L. (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Spector, Timothy D. (author)
- Kings Coll London, St Thomas Hosp, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England.
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- Speliotes, Elizabeth K. (author)
- Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
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- Goddard, Michael E. (author)
- Dept Primary Ind, Biosci Res Div, Melbourne, Vic, Australia.;Univ Melbourne, Dept Food & Agr Syst, Melbourne, Vic, Australia.
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- Yang, Jian (author)
- Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.;Univ Queensland, Translat Res Inst, Diamantina Inst, Brisbane, Qld, Australia.
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- Visscher, Peter M. (author)
- Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.;Univ Queensland, Translat Res Inst, Diamantina Inst, Brisbane, Qld, Australia.
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Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia Erasmus Univ, Dept Internal Med, Med Ctr, Rotterdam, Netherlands. (creator_code:org_t)
- 2015-09-14
- 2015
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 47:11, s. 1357-1362
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Across-nation differences in the mean values for complex traits are common(1-8), but the reasons for these differences are unknown. Here we find that many independent loci contribute to population genetic differences in height and body mass index (BMI) in 9,416 individuals across 14 European countries. Using discovery data on over 250,000 individuals and unbiased effect size estimates from 17,500 sibling pairs, we estimate that 24% (95% credible interval (CI) = 9%, 41%) and 8% (95% CI = 4%, 16%) of the captured additive genetic variance for height and BMI, respectively, reflect population genetic differences. Population genetic divergence differed significantly from that in a null model (height, P < 3.94 x 10(-8); BMI, P < 5.95 x 10(-4)), and we find an among-population genetic correlation for tall and slender individuals (r = -0.80, 95% CI = -0.95, -0.60), consistent with correlated selection for both phenotypes. Observed differences in height among populations reflected the predicted genetic means (r = 0.51; P < 0.001), but environmental differences across Europe masked genetic differentiation for BMI (P < 0.58).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Robinson, Matthe ...
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Hemani, Gibran
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Medina-Gomez, Ca ...
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Mezzavilla, Mass ...
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Esko-, Tonu
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Shakhbazov, Kons ...
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show more...
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Powell, Joseph E ...
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Vinkhuyzen, Anna
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Berndt, Sonja I.
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Gustafsson, Stef ...
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Justice, Anne E.
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Kahali, Bratati
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Locke, Adam E.
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Pers, Tune H.
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Vedantam, Sailaj ...
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Wood, Andrew R.
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van Rheenen, Wou ...
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Andreassen, Ole ...
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Gasparini, Paolo
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Metspalu, Andres
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van den Berg, Le ...
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Veldink, Jan H.
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Rivadeneira, Fer ...
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Werge, Thomas M.
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Abecasis, Goncal ...
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Boomsma, Dorret ...
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Chasman, Daniel ...
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de Geus, Eco J. ...
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Frayling, Timoth ...
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Hirschhorn, Joel ...
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Hottenga, Jouke ...
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Ingelsson, Erik
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Loos, Ruth J. F.
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Magnusson, Patri ...
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Martin, Nicholas ...
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Montgomery, Gran ...
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North, Kari E.
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Pedersen, Nancy ...
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Spector, Timothy ...
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Speliotes, Eliza ...
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Goddard, Michael ...
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Yang, Jian
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Visscher, Peter ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University
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Karolinska Institutet