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  • Burri, RetoUppsala universitet,Evolutionsbiologi (författare)

Linked selection and recombination rate variation drive the evolution of the genomic landscape of differentiation across the speciation continuum of Ficedula flycatchers

  • Artikel/kapitelEngelska2015

Förlag, utgivningsår, omfång ...

  • 2015-09-09
  • Cold Spring Harbor Laboratory,2015
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-268800
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-268800URI
  • https://doi.org/10.1101/gr.196485.115DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Speciation is a continuous process during which genetic changes gradually accumulate in the genomes of diverging species. Recent studies have documented highly heterogeneous differentiation landscapes, with distinct regions of elevated differentiation ("differentiation islands") widespread across genomes. However, it remains unclear which processes drive the evolution of differentiation islands; how the differentiation landscape evolves as speciation advances; and ultimately, how differentiation islands are related to speciation. Here, we addressed these questions based on population genetic analyses of 200 resequenced genomes from 10 populations of four Ficedula flycatcher sister species. We show that a heterogeneous differentiation landscape starts emerging among populations within species, and differentiation islands evolve recurrently in the very same genomic regions among independent lineages. Contrary to expectations from models that interpret differentiation islands as genomic regions involved in reproductive isolation that are shielded from gene flow, patterns of sequence divergence (d(XY) relative node depth) do not support a major role of gene flow in the evolution of the differentiation landscape in these species. Instead, as predicted by models of linked selection, genome-wide variation in diversity and differentiation can be explained by variation in recombination rate and the density of targets for selection. We thus conclude that the heterogeneous landscape of differentiation in Ficedula flycatchers evolves mainly as the result of background selection and selective sweeps in genomic regions of low recombination. Our results emphasize the necessity of incorporating linked selection as a null model to identify genome regions involved in adaptation and speciation.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Nater, AlexanderUppsala universitet,Evolutionsbiologi(Swepub:uu)alena213 (författare)
  • Kawakami, TakeshiUppsala universitet,Evolutionsbiologi(Swepub:uu)takka124 (författare)
  • Mugal, Carina F.Uppsala universitet,Evolutionsbiologi(Swepub:uu)carmu820 (författare)
  • Ólason, Páll I.Uppsala universitet,Molekylär evolution(Swepub:uu)palol405 (författare)
  • Smeds, LinneaUppsala universitet,Evolutionsbiologi(Swepub:uu)linsm456 (författare)
  • Suh, AlexanderUppsala universitet,Evolutionsbiologi(Swepub:uu)alesu519 (författare)
  • Dutoit, LudovicUppsala universitet,Evolutionsbiologi(Swepub:uu)luddu368 (författare)
  • Bures, StanislavPalacky Univ, Dept Zool, Lab Ornithol, Olomouc 77146, Czech Republic. (författare)
  • Garamszegi, Laszlo Z.CSIC, Dept Evolutionary Ecol, Estn Biol Donana, Seville 41092, Spain. (författare)
  • Hogner, SiljeUniv Oslo, Ctr Ecol & Evolutionary Synth, Dept Biosci, N-0316 Oslo, Norway.;Univ Oslo, Nat Hist Museum, N-0318 Oslo, Norway. (författare)
  • Moreno, JuanCSIC, Museo Nacl Ciencias Nat, E-28006 Madrid, Spain. (författare)
  • Qvarnström, AnnaUppsala universitet,Zooekologi(Swepub:uu)annaqvar (författare)
  • Ruzic, MilanBird Protect & Study Soc Serbia, Novi Sad 21000, Serbia. (författare)
  • Saether, Stein-AreUniv Oslo, Ctr Ecol & Evolutionary Synth, Dept Biosci, N-0316 Oslo, Norway.;Norwegian Inst Nat Res NINA, N-7034 Trondheim, Norway. (författare)
  • Saetre, Glenn-PeterUniv Oslo, Ctr Ecol & Evolutionary Synth, Dept Biosci, N-0316 Oslo, Norway. (författare)
  • Toeroek, JanosEotvos Lorand Univ, Dept Systemat Zool & Ecol, Behav Ecol Grp, H-1117 Budapest, Hungary. (författare)
  • Ellegren, HansUppsala universitet,Evolutionsbiologi(Swepub:uu)hanselle (författare)
  • Uppsala universitetEvolutionsbiologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Genome Research: Cold Spring Harbor Laboratory25:11, s. 1656-16651088-90511549-5469

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