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  • Persson, JonasKarolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Karolinska Inst, S-18288 Danderyd, Sweden. (författare)

Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease

  • Artikel/kapitelEngelska2015

Förlag, utgivningsår, omfång ...

  • WILEY-BLACKWELL,2015
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-269285
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-269285URI
  • https://doi.org/10.1161/JAHA.115.001853DOI
  • https://lup.lub.lu.se/record/7840966URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-123165URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:132387554URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-112288URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding: IMPROVE was supported by the European Commission (Contract number: QLG1-CT-2002-00896), the Swedish Heart-Lung Foundation, the Swedish Research Council (projects 8691 and 0593), the Knut and Alice Wallenberg Foundation, the Foundation for Strategic Research, the Stockholm County Council (project 592229), the Strategic Cardiovascular and Diabetes Programmes of Karolinska Institutet and Stockholm County Council, the European Union Framework Programme 7 (FP7/2007-2013) for the Innovative Medicine Initiative under grant agreement no. IMI/115006 (the SUMMIT consortium), the Academy of Finland (Grant #110413), the British Heart Foundation (RG2008/08, RG2008/014) and the Italian Ministry of Health (Ricerca Corrente). The SNP Technology Platform is supported by Uppsala University, Uppsala University Hospital and the Swedish Research Council for Infrastructures. Persson is supported by the Stockholm County Council (clinical postdoctorial appointment). Strawbridge is supported by Swedish Heart-Lung Foundation (20120600), the Tore Nilsson, Gamla Tjanarinnor and Thurings foundations. Gertow acknowledges support from the Swedish Heart-Lung Foundation and Stiftelsen for Gamla Tjanarinnor. Sabater-Lleal is supported by the Swedish Heart-Lung Foundation (20130399), and acknowledges funding from Ake Wiberg and Tore Nilssons foundations. Sennblad acknowledges funding from the Magnus Bergvall Foundation and the Foundation for Old Servants. Rauramaa acknowledges the Ministry of Education and Culture in Finland. S.So. is supported by the Vasterbotten County Council (ALF) and the Swedish Heart and Lung Foundation. AGT is supported by TAMOP 4.2.4.A/1-11-1-2012-0001 National Excellence Program - research fellowship co-financed by the European Union and the European Social Fund. M.K. is supported by the UK Medical Research Council (K013351), the Economic and Social Research Council and the Academy of Finland. The University College London Genetics Institute supported S.Sh.
  • Funding Agencies|European Commission [QLG1-CT-2002-00896]; Swedish Heart-Lung Foundation; Swedish Research Council [8691, 0593]; Knut and Alice Wallenberg Foundation; Foundation for Strategic Research; Stockholm County Council [592229]; Karolinska Institutet; Stockholm County Council; European Union Framework Programme 7 for the Innovative Medicine Initiative [IMI/115006]; Academy of Finland [110413]; British Heart Foundation [RG2008/08, RG2008/014]; Italian Ministry of Health (Ricerca Corrente); Uppsala University; Uppsala University Hospital; Swedish Research Council for Infrastructures; Swedish Heart-Lung Foundation [20120600, 20130399]; Tore Nilsson foundation; Gamla Tjanarinnor foundation; Thurings foundation; Stiftelsen for Gamla Tjanarinnor; Ake Wiberg foundation; Tore Nilssons foundation; Magnus Bergvall Foundation; Foundation for Old Servants; Ministry of Education and Culture in Finland; Vasterbotten County Council; Swedish Heart and Lung Foundation; National Excellence Program [TAMOP 4.2.4.A/1-11-1-2012-0001]; European Union; European Social Fund; UK Medical Research Council [K013351]; Economic and Social Research Council; Academy of Finland; University College London Genetics Institute
  • Background-Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT. Methods and Results-Baseline plasma adiponectin concentrationwas tested for association with baseline IMT, IMT progression over 30 months, and occurrence of cardiovascular events within 3 years in 3430 participants (women, n=1777; men, n=1653) with high cardiovascular risk but no prevalent disease. Plasma adiponectin levels were inversely associated with baseline mean bifurcation IMT after adjustment for established risk factors (beta=-0.018, P<0.001) in men but not in women (beta=-0.006, P=0.185; P for interaction=0.061). Adiponectin levels were inversely associated with progression of mean common carotid IMT in men (beta=-0.0022, P=0.047), whereas no association was seen in women (0.0007, P=0.475; P for interaction=0.018). Moreover, we observed that adiponectin levels were inversely associated with coronary events in women (hazard ratio 0.57, 95% CI 0.37 to 0.87) but not in men (hazard ratio 0.82,95% CI0.54 to 1.25). Agenescore of adiponectin-raisingalleles in6loci, reported recently inalarge multi-ethnic metaanalysis, was inversely associated with baseline mean bifurcation IMT in men (beta=-0.0008, P=0.004) but not in women (beta=-0.0003, P=0.522; P for interaction=0.007). Conclusions-This report provides some evidence for adiponectin protecting against atherosclerosis, with effects being confined to men; however, compared with established cardiovascular risk factors, the effect of plasma adiponectin was modest. Further investigation involving mechanistic studies is warranted.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Strawbridge, Rona J.Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden. (författare)
  • McLeod, OlgaKarolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.,Karolinska Institute, Sweden (författare)
  • Gertow, KarlKarolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;Karolinska Inst, Div Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden. (författare)
  • Silveira, AngelaKarolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden. (författare)
  • Baldassarre, DamianoUniv Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy.,University of Milan, Italy (författare)
  • Van Zuydam, NatalieUniv Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee DD1 4HN, Scotland.,University of Dundee, Scotland (författare)
  • Shah, SoniaUCL, Genet Inst, London, England.;Univ Queensland, Diamantina Inst, Brisbane, Qld 4072, Australia.;Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia.,UCL, England; University of Queensland, Australia; University of Queensland, Australia (författare)
  • Fava, CristianoLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden; University of Verona, Italy,Lund Univ, Skane Univ Hosp, Dept Clin Sci, Clin Res Ctr, Malmo, Sweden.;Univ Verona, Hosp Policlin GB Rossi, Dept Med, Div Internal Med C, I-37100 Verona, Italy.(Swepub:lu)endo-cfa (författare)
  • Gustafsson, StefanUppsala universitet,Molekylär epidemiologi,Uppsala University, Sweden(Swepub:uu)stegu732 (författare)
  • Veglia, FabrizioUniv Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy.,University of Milan, Italy (författare)
  • Sennblad, BengtKarolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;Karolinska Inst, Sci Life Lab, Stockholm, Sweden. (författare)
  • Larsson, MalinLinköpings universitet,Bioinformatik,Tekniska fakulteten,Linkoping Univ, IFM Bioinformat, Linkoping, Sweden.(Swepub:liu)malla74 (författare)
  • Sabater-Lleal, MariaKarolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden. (författare)
  • Leander, KarinKarolinska Institutet (författare)
  • Gigante, BrunaKarolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Karolinska Inst, S-18288 Danderyd, Sweden.;Karolinska Inst, Div Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden. (författare)
  • Tabak, AdamSemmelweis Univ, Fac Med, Dept Med 1, H-1085 Budapest, Hungary.,Semmelweis University, Hungary (författare)
  • Kivimaki, MikaUCL, Dept Epidemiol & Publ Hlth, London, England. (författare)
  • Kauhanen, JussiUniv Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.,University of Eastern Finland, Finland (författare)
  • Rauramaa, RainerKuopio Res Inst Exercise Med, Kuopio, Finland.;Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, SF-70210 Kuopio, Finland.,Kuopio Research Institute Exercise Med, Finland; Kuopio University Hospital, Finland (författare)
  • Smit, Andries J.Univ Groningen, Univ Med Ctr Groningen, Dept Med, NL-9700 AB Groningen, Netherlands.,University of Groningen, Netherlands (författare)
  • Mannarino, ElmoUniv Perugia, Dept Clin & Expt Med, Internal Med Angiol & Arteriosclerosis Dis, I-06100 Perugia, Italy.,University of Perugia, Italy (författare)
  • Giral, PhilippeGrp Hosp Pitie Salpetriere, AP HP, Serv Endocrinol Metab, Unites Prevent Cardiovasc, F-75634 Paris, France.,Grp Hospital Pitie Salpetriere, France (författare)
  • Humphries, Steve E.UCL, Ctr Cardiovasc Genet, London, England. (författare)
  • Tremoli, ElenaUniv Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy.,University of Milan, Italy (författare)
  • de Faire, UlfKarolinska Institutet,Karolinska Inst, Div Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden. (författare)
  • Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi,Uppsala University, Sweden(Swepub:uu)larslind (författare)
  • Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Uppsala University, Sweden(Swepub:uu)ering425 (författare)
  • Hedblad, BoLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden,Lund Univ, Skane Univ Hosp, Dept Clin Sci, Clin Res Ctr, Malmo, Sweden.(Swepub:lu)medf-bhe (författare)
  • Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden,Lund Univ, Skane Univ Hosp, Dept Clin Sci, Clin Res Ctr, Malmo, Sweden.(Swepub:lu)endo-ome (författare)
  • Kumari, MeenaUCL, Genet Epidemiol Grp, Dept Epidemiol & Publ Hlth, London, England. (författare)
  • Hingorani, AroonKarolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;UCL, Genet Epidemiol Grp, Dept Epidemiol & Publ Hlth, London, England.,Karolinska Institute, Sweden; UCL, England (författare)
  • Morris, Andrew D.Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee DD1 4HN, Scotland.,University of Dundee, Scotland (författare)
  • Palmer, Colin N. A.Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee DD1 4HN, Scotland.,University of Dundee, Scotland (författare)
  • Lundman, PiaKarolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Karolinska Inst, S-18288 Danderyd, Sweden. (författare)
  • Ohrvik, JohnKarolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.,Karolinska Institute, Sweden (författare)
  • Söderberg, StefanUmeå universitet,Kardiologi,Umea Univ, Dept Publ Hlth & Clin Med, Div Med, S-90187 Umea, Sweden.(Swepub:umu)stso0001 (författare)
  • Hamsten, Anders (författare)
  • Karolinska InstitutetDanderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Karolinska Inst, S-18288 Danderyd, Sweden. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of the American Heart Association: WILEY-BLACKWELL4:82047-9980

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