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Impact of adolescen...
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Granholm, LinneaUppsala universitet,Institutionen för farmaceutisk biovetenskap
(author)
Impact of adolescent ethanol exposure and adult amphetamine self-administration on evoked striatal dopamine release in male rats
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-09-26
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Springer Science and Business Media LLC,2015
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-270438
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-270438URI
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https://doi.org/10.1007/s00213-015-4070-3DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Adolescent binge drinking is common and associated with increased risk of substance use disorders. Transition from recreational to habitual ethanol consumption involves alterations in dorsal striatal function, but the long-term impact of adolescent ethanol exposure upon this region remains unclear. This study aimed to characterise and describe relationships between adolescent ethanol exposure, amphetamine self-administration and adult dopamine dynamics in dorsal striatum, including response to amphetamine challenge, in male Wistar rats. Ethanol (2 g/kg) or water was administered intragastrically in an episodic binge-like regimen (three continuous days/week) between 4 and 9 weeks of age (i.e. post-natal days 28-59). In adulthood, animals were divided into two groups. In the first, dorsal striatal potassium-evoked dopamine release was examined via chronoamperometry, in the basal state and after a single amphetamine challenge (2 mg/kg, i.v.). In the second, amphetamine self-administration behaviour was studied (i.e. fixed and progressive ratio) before chronoamperometric analysis was conducted as described above. Adolescent ethanol exposure suppressed locally evoked dopamine response after amphetamine challenge in adulthood, whereas in the basal state, no differences in dopamine dynamics were detected. Ethanol-exposed animals showed no differences in adult amphetamine self-administration behaviour but an abolished effect on dopamine removal in response to a single amphetamine challenge after self-administration. Amphetamine challenges in adult rats revealed differences in in vivo dopamine function after adolescent ethanol exposure. The attenuated drug response in ethanol-exposed animals may affect habit formation and contribute to increased risk for substance use disorders as a consequence of adolescent ethanol.
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Rowley, S.Uppsala universitet,Institutionen för farmaceutisk biovetenskap
(author)
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Ellgren, M.Uppsala universitet,Institutionen för farmaceutisk biovetenskap
(author)
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Segerström, LovaUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)loseg226
(author)
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Nylander, IngridUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)iny08577
(author)
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Uppsala universitetInstitutionen för farmaceutisk biovetenskap
(creator_code:org_t)
Related titles
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In:Psychopharmacology: Springer Science and Business Media LLC232:24, s. 4421-44310033-31581432-2072
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