Impact of adolescent ethanol exposure and adult amphetamine self-administration on evoked striatal dopamine release in male rats

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Granholm, LinneaUppsala universitet,Institutionen för farmaceutisk biovetenskap (author)

Impact of adolescent ethanol exposure and adult amphetamine self-administration on evoked striatal dopamine release in male rats

Article/chapterEnglish2015

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2015-09-26
Springer Science and Business Media LLC,2015
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LIBRIS-ID:oai:DiVA.org:uu-270438
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-270438URI
https://doi.org/10.1007/s00213-015-4070-3DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Adolescent binge drinking is common and associated with increased risk of substance use disorders. Transition from recreational to habitual ethanol consumption involves alterations in dorsal striatal function, but the long-term impact of adolescent ethanol exposure upon this region remains unclear. This study aimed to characterise and describe relationships between adolescent ethanol exposure, amphetamine self-administration and adult dopamine dynamics in dorsal striatum, including response to amphetamine challenge, in male Wistar rats. Ethanol (2 g/kg) or water was administered intragastrically in an episodic binge-like regimen (three continuous days/week) between 4 and 9 weeks of age (i.e. post-natal days 28-59). In adulthood, animals were divided into two groups. In the first, dorsal striatal potassium-evoked dopamine release was examined via chronoamperometry, in the basal state and after a single amphetamine challenge (2 mg/kg, i.v.). In the second, amphetamine self-administration behaviour was studied (i.e. fixed and progressive ratio) before chronoamperometric analysis was conducted as described above. Adolescent ethanol exposure suppressed locally evoked dopamine response after amphetamine challenge in adulthood, whereas in the basal state, no differences in dopamine dynamics were detected. Ethanol-exposed animals showed no differences in adult amphetamine self-administration behaviour but an abolished effect on dopamine removal in response to a single amphetamine challenge after self-administration. Amphetamine challenges in adult rats revealed differences in in vivo dopamine function after adolescent ethanol exposure. The attenuated drug response in ethanol-exposed animals may affect habit formation and contribute to increased risk for substance use disorders as a consequence of adolescent ethanol.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
Chronoamperometry
Operant self-administration
Alcohol
Rodents

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Rowley, S.Uppsala universitet,Institutionen för farmaceutisk biovetenskap (author)
Ellgren, M.Uppsala universitet,Institutionen för farmaceutisk biovetenskap (author)
Segerström, LovaUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)loseg226 (author)
Nylander, IngridUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)iny08577 (author)
Uppsala universitetInstitutionen för farmaceutisk biovetenskap (creator_code:org_t)

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In:Psychopharmacology: Springer Science and Business Media LLC232:24, s. 4421-44310033-31581432-2072

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By the author/editor: Granholm, Linnea; Rowley, S.; Ellgren, M.; Segerström, Lova; Nylander, Ingrid

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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