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A prospective, acti...
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Knutson, FolkeUppsala universitet,Institutionen för immunologi, genetik och patologi
(författare)
A prospective, active haemovigilance study with combined cohort analysis of 19 175 transfusions of platelet components prepared with amotosalen-UVA photochemical treatment
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
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2015-05-15
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Wiley,2015
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-271041
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-271041URI
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https://doi.org/10.1111/vox.12287DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background and Objectives A photochemical treatment process (PCT) utilizing amotosalen and UVA light (INTERCEPT (TM) Blood System) has been developed for inactivation of viruses, bacteria, parasites and leucocytes that can contaminate blood components intended for transfusion. The objective of this study was to further characterize the safety profile of INTERCEPT-treated platelet components (PCT-PLT) administered across a broad patient population. Materials and Methods This open-label, observational haemovigilance programme of PCT-PLT transfusions was conducted in 21 centres in 11 countries. All transfusions were monitored for adverse events within 24 h post-transfusion and for serious adverse events (SAEs) up to 7 days post-transfusion. All adverse events were assessed for severity (Grade 0-4), and causal relationship to PCT-PLT transfusion. Results Over the course of 7 years in the study centres, 4067 patients received 19 175 PCT-PLT transfusions. Adverse events were infrequent, and most were of Grade 1 severity. On a per-transfusion basis, 123 (0.6%) were classified an acute transfusion reaction (ATR) defined as an adverse event related to the transfusion. Among these ATRs, the most common were chills (77, 0.4%) and urticaria (41, 0.2%). Fourteen SAEs were reported, of which 2 were attributed to platelet transfusion (<0.1%). No case of transfusion-related acute lung injury, transfusion-associated graft-versus-host disease, transfusion-transmitted infection or death was attributed to the transfusion of PCT-PLT. Conclusion This longitudinal haemovigilance safety programme to monitor PCT-PLT transfusions demonstrated a low rate of ATRs, and a safety profile consistent with that previously reported for conventional platelet components.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Osselaer, J.Catholic Univ Louvain, Clin Univ Mont Godinne, Yvoir, Belgium.
(författare)
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Pierelli, L.Univ Roma La Sapienza, Dept Expt Med, I-00185 Rome, Italy.
(författare)
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Lozano, M.Hosp Clin Barcelona, IDIBAPS, CDB, Dept Hemotherapy & Hemostasis, Barcelona, Spain.
(författare)
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Cid, J.Hosp Clin Barcelona, IDIBAPS, CDB, Dept Hemotherapy & Hemostasis, Barcelona, Spain.
(författare)
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Tardivel, R.EFS Bretagne, Rennes, France.
(författare)
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Garraud, O.EFS Auvergne Loire, St Etienne, France.
(författare)
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Hervig, T.Univ Bergen, Dept Immunol & Transfus Med, Bergen, Norway.
(författare)
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Domanovic, D.Blood Transfus Ctr Slovenia, Ljubljana, Slovenia.
(författare)
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Cukjati, M.Blood Transfus Ctr Slovenia, Ljubljana, Slovenia.
(författare)
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Gudmundson, S.Natl Univ Hosp Reykjavik, Blood Bank, Reykjavik, Iceland.
(författare)
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Hjalmarsdottir, I. B.Natl Univ Hosp Reykjavik, Blood Bank, Reykjavik, Iceland.
(författare)
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Castrillo, A.Transfus Ctr Galicia, Santiago De Compostela, Spain.
(författare)
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Gonzalez, R.Transfus Ctr Galicia, Santiago De Compostela, Spain.
(författare)
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Brihante, D.Inst Portugues Oncol Lisboa, Serv Imunohemoterapia, Lisbon, Portugal.
(författare)
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Santos, M.Inst Portugues Oncol Lisboa, Serv Imunohemoterapia, Lisbon, Portugal.
(författare)
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Schlenke, P.Med Univ Graz, Dept Blood Grp Serol & Transfus Med, Graz, Austria.
(författare)
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Elliott, A.Cerus Corp, Concord, CA 94520 USA.
(författare)
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Lin, J. -S
(författare)
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Tappe, D.Cerus Corp, Concord, CA 94520 USA.
(författare)
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Stassinopoulos, A.Cerus Corp, Concord, CA 94520 USA.
(författare)
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Green, J.Cerus Corp, Concord, CA 94520 USA.
(författare)
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Corash, L.Cerus Corp, Concord, CA 94520 USA.
(författare)
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Uppsala universitetInstitutionen för immunologi, genetik och patologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Vox Sanguinis: Wiley109:4, s. 343-3520042-90071423-0410
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Till lärosätets databas
- Av författaren/redakt...
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Knutson, Folke
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Osselaer, J.
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Pierelli, L.
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Lozano, M.
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Cid, J.
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Tardivel, R.
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visa fler...
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Garraud, O.
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Hervig, T.
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Domanovic, D.
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Cukjati, M.
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Gudmundson, S.
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Hjalmarsdottir, ...
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Castrillo, A.
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Gonzalez, R.
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Brihante, D.
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Santos, M.
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Schlenke, P.
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Elliott, A.
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Lin, J. -S
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Tappe, D.
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Stassinopoulos, ...
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Green, J.
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Corash, L.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Vox Sanguinis
- Av lärosätet
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Uppsala universitet