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Meta-analysis of re...
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Emmert, KirstenUniv Geneva, Dept Radiol & Med Informat, Geneva, Switzerland.;Ecole Polytech Fed Lausanne, Inst Bioengn, Med Image Proc Lab, Lausanne, Switzerland.
(författare)
Meta-analysis of real-time fMRI neurofeedback studies using individual participant data : How is brain regulation mediated?
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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Elsevier BV,2016
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-274275
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-274275URI
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https://doi.org/10.1016/j.neuroimage.2015.09.042DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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An increasing number of studies using real-time fMRI neurofeedback have demonstrated that successful regulation of neural activity is possible in various brain regions. Since these studies focused on the regulated region(s), little is known about the target-independent mechanisms associated with neurofeedback-guided control of brain activation, i.e. the regulating network. While the specificity of the activation during self-regulation is an important factor, no study has effectively determined the network involved in self-regulation in general. In an effort to detect regions that are responsible for the act of brain regulation, we performed a post-hoc analysis of data involving different target regions based on studies from different research groups. We included twelve suitable studies that examined nine different target regions amounting to a total of 175 subjects and 899 neurofeedback runs. Data analysis included a standard first-(single subject, extracting main paradigm) and second-level (single subject, all runs) general linear model (GLM) analysis of all participants taking into account the individual timing. Subsequently, at the third level, a random effects model GLM included all subjects of all studies, resulting in an overall mixed effects model. Since four of the twelve studies had a reduced field of view (FoV), we repeated the same analysis in a subsample of eight studies that had a well-overlapping FoV to obtain a more global picture of self-regulation. The GLM analysis revealed that the anterior insula as well as the basal ganglia, notably the striatum, were consistently active during the regulation of brain activation across the studies. The anterior insula has been implicated in interoceptive awareness of the body and cognitive control. Basal ganglia are involved in procedural learning, visuomotor integration and other higher cognitive processes including motivation. The larger FoV analysis yielded additional activations in the anterior cingulate cortex, the dorsolateral and ventrolateral prefrontal cortex, the temporo-parietal area and the visual association areas including the temporo-occipital junction. In conclusion, we demonstrate that several key regions, such as the anterior insula and the basal ganglia, are consistently activated during self-regulation in real-time fMRI neurofeedback independent of the targeted region-ofinterest. Our results imply that if the real-time fMRI neurofeedback studies target regions of this regulation network, such as the anterior insula, care should be given whether activation changes are related to successful regulation, or related to the regulation process per se. Furthermore, future research is needed to determine how activation within this regulation network is related to neurofeedback success.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kopel, RotemUniv Geneva, Dept Radiol & Med Informat, Geneva, Switzerland.;Ecole Polytech Fed Lausanne, Inst Bioengn, Med Image Proc Lab, Lausanne, Switzerland.
(författare)
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Sulzer, JamesUniv Texas Austin, Dept Mech Engn, Austin, TX 78712 USA.
(författare)
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Bruehl, Annette B.Univ Zurich, Hosp Psychiat, Dept Psychiat Psychotherapy & Psychosomat, Zurich, Switzerland.;Univ Cambridge, Behav & Clin Neurosci Inst, Dept Psychiat, Cambridge, England.
(författare)
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Berman, Brian D.Univ Colorado, Dept Neurol, Aurora, CO USA.
(författare)
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Linden, David E. J.Cardiff Univ, Sch Med, MRC Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales.
(författare)
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Horovitz, Silvina G.NINDS, NIH, Bethesda, MD 20892 USA.
(författare)
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Breimhorst, MarkusJohannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Neurol, D-55122 Mainz, Germany.
(författare)
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Caria, AndreaUniv Tubingen, Inst Med Psychol & Behav Neurobiol, Tubingen, Germany.
(författare)
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Frank, SabineUniv Tubingen, Inst Med Psychol & Behav Neurobiol, Tubingen, Germany.
(författare)
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Johnston, Stephen
(författare)
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Long, ZhiyingSwansea Univ, Dept Psychol, Swansea, W Glam, Wales.;Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.;Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China.
(författare)
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Paret, ChristianHeidelberg Univ Mannheim, Med Fac Mannheim, Cent Inst Mental Hlth Mannheim, Dept Psychosomat Med & Psychotherapy, Mannheim, Germany.;Heidelberg Univ Mannheim, Med Fac Mannheim, Cent Inst Mental Hlth Mannheim, Dept Neuroimaging, Mannheim, Germany.
(författare)
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Robineau, FabienUniv Geneva, Dept Neurosci, Lab Neurol & Imaging Cognit, CH-1211 Geneva 4, Switzerland.
(författare)
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Veit, RalfUniv Tubingen, Inst Med Psychol & Behav Neurobiol, Tubingen, Germany.;Univ Tubingen, Helmholtz Ctr Munich, Inst Diabet Res & Metab Dis, Tubingen, Germany.
(författare)
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Bartsch, AndreasHeidelberg Univ, Dept Neuroradiol, Heidelberg, Germany.;Univ Wurzburg, Dept Neuroradiol, D-97070 Wurzburg, Germany.;Univ Oxford, FMRIB Ctr, Oxford, England.;Bamberg Hosp, Dept Radiol, Bamberg, Germany.
(författare)
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Beckmann, Christian F.Radboud Univ Nijmegen, Ctr Cognit Neuroimaging, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands.;Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neuroimaging, NL-6525 ED Nijmegen, Netherlands.;Univ Oxford, Oxford Ctr Funct MRI Brain, Nuffield Dept Clin Neurosci, Oxford OX1 2JD, England.
(författare)
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Van De Ville, DimitriUniv Geneva, Dept Radiol & Med Informat, Geneva, Switzerland.;Ecole Polytech Fed Lausanne, Inst Bioengn, Med Image Proc Lab, Lausanne, Switzerland.
(författare)
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Haller, SvenUppsala universitet,Radiologi,Affidea Ctr Diagnost Radiolog Carouge CDRC, Geneva, Switzerland.;Univ Hosp Freiburg, Dept Neuroradiol, Freiburg, Germany.;Univ Geneva, Fac Med, CH-1211 Geneva 4, Switzerland.(Swepub:uu)sveha228
(författare)
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Univ Geneva, Dept Radiol & Med Informat, Geneva, Switzerland.;Ecole Polytech Fed Lausanne, Inst Bioengn, Med Image Proc Lab, Lausanne, Switzerland.Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USA.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:NeuroImage: Elsevier BV124:Part A, s. 806-8121053-81191095-9572
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Emmert, Kirsten
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Kopel, Rotem
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Sulzer, James
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Bruehl, Annette ...
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Berman, Brian D.
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Linden, David E. ...
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visa fler...
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Horovitz, Silvin ...
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Breimhorst, Mark ...
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Caria, Andrea
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Frank, Sabine
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Johnston, Stephe ...
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Long, Zhiying
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Paret, Christian
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Robineau, Fabien
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Veit, Ralf
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Bartsch, Andreas
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Beckmann, Christ ...
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Van De Ville, Di ...
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Haller, Sven
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