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  • Ganna, AndreaUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab (author)

Large-scale non-targeted metabolomic profiling in three human population-based studies

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2015-11-07
  • Springer Science and Business Media LLC,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-274799
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-274799URI
  • https://doi.org/10.1007/s11306-015-0893-5DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:132742649URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Ganna and Fall equal contributions as first author
  • Non-targeted metabolomic profiling is used to simultaneously assess a large part of the metabolome in a biological sample. Here, we describe both the analytical and computational methods used to analyze a large UPLC–Q-TOF MS-based metabolomic profiling effort using plasma and serum samples from participants in three Swedish population-based studies of middle-aged and older human subjects: TwinGene, ULSAM and PIVUS. At present, more than 200 metabolites have been manually annotated in more than 3600 participants using an in-house library of standards and publically available spectral databases. Data available at the metabolights repository include individual raw unprocessed data, processed data, basic demographic variables and spectra of annotated metabolites. Additional phenotypical and genetic data is available upon request to cohort steering committees. These studies represent a unique resource to explore and evaluate how metabolic variability across individuals affects human diseases.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Fall, ToveUppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi(Swepub:uu)tovfa878 (author)
  • Salihovic, SamiraKarolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)samsa560 (author)
  • Lee, Woojoo (author)
  • Broeckling, Corey D. (author)
  • Kumar, JitenderUppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi(Swepub:uu)jitku786 (author)
  • Hägg, Sara (author)
  • Stenemo, MarkusUppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi(Swepub:uu)marst420 (author)
  • Magnusson, Patrik K.E.Karolinska Institutet (author)
  • Prenni, Jessica E. (author)
  • Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
  • Pawitan, YudiKarolinska Institutet (author)
  • Ingelsson, ErikUppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi(Swepub:uu)ering425 (author)
  • Uppsala universitetMolekylär epidemiologi (creator_code:org_t)

Related titles

  • In:Metabolomics: Springer Science and Business Media LLC121573-38821573-3890

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