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Contribution of che...
Contribution of chemotherapy mobilization to disease control in multiple myeloma treated with autologous hematopoietic cell transplantation
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- Uy, G. L. (author)
- Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
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- Costa, L. J. (author)
- Univ Alabama Birmingham, Dept Med, Div Hematol Oncol, Birmingham, AL 35294 USA.
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- Hari, P. N. (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Zhang, M-J (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Div Biostat, Inst Hlth & Soc, Milwaukee, WI 53226 USA.
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- Huang, J-X (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Anderson, K. C. (author)
- Dana Farber Canc Inst, Hematol Oncol Treatment Ctr, Boston, MA 02115 USA.
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- Bredeson, C. N. (author)
- Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada.;Ottawa Hosp, Res Inst, Ottawa, ON, Canada.
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- Callander, N. S. (author)
- Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA.
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- Cornell, R. F. (author)
- Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.
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- Perez, M. A. D. (author)
- Univ Nino Jesus, Serv Oncohematol, Hosp Infantil, Madrid, Spain.
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- Dispenzieri, A. (author)
- Mayo Clin, Dept Hematol, Rochester, MN USA.
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- Freytes, C. O. (author)
- South Texas Vet Hlth Care Syst, San Antonio, TX USA.;Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
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- Gale, R. P. (author)
- Univ London Imperial Coll Sci Technol & Med, Dept Med, Div Expt Med, Hematol Res Ctr, London, England.
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- Garfall, A. (author)
- Univ Penn, Abramson Canc Ctr, Perelman Ctr Adv Med, Div Hematol Oncol, Philadelphia, PA 19104 USA.
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- Gertz, M. A. (author)
- Mayo Clin, Dept Hematol, Rochester, MN USA.
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- Gibson, J. (author)
- Royal Prince Alfred Hosp, Dept Haematol, Inst Haematol, Camperdown, NSW 2050, Australia.
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- Hamadani, M. (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Lazarus, H. M. (author)
- Univ Hosp, Seidman Canc Ctr, Case Med Ctr, Cleveland, OH USA.
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- Kalaycio, M. E. (author)
- Cleveland Clin, Hematol Oncol & Blood Disorders, Cleveland, OH 44106 USA.
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- Kamble, R. T. (author)
- Baylor Coll Med, Ctr Cell & Gene Therapy, Dept Hematol & Oncol, Houston, TX 77030 USA.
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- Kharfan-Dabaja, M. A. (author)
- Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL 33612 USA.
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- Krishnan, A. Y. (author)
- City Hope Natl Med Ctr, Dept Hematol Oncol, Duarte, CA 91010 USA.
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- Kumar, S. K. (author)
- Mayo Clin, Dept Hematol, Rochester, MN USA.
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- Kyle, R. A. (author)
- Mayo Clin, Dept Hematol, Rochester, MN USA.
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- Landau, H. J. (author)
- Mem Sloan Kettering Canc Ctr, Bone Marrow Transplant Serv, New York, NY 10021 USA.
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- Lee, C. H. (author)
- Royal Adelaide Hosp, SA Pathol, Haematol & Bone Marrow Transplant Unit, Adelaide, SA 5000, Australia.
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- Maiolino, A. (author)
- Univ Fed Rio de Janeiro, Hosp Univ Clementinio Fraga Filho, Rio De Janeiro, Brazil.
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- Marks, D. I. (author)
- Univ Hosp Bristol NHS Trust, Pediat Bone Marrow Transplant, Bristol, Avon, England.
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- Mark, T. M. (author)
- New York Presbyterian Hosp Cornell, Dept Med, New York, NY USA.
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- Munker, R. (author)
- Louisiana State Univ Hlth Shreveport, Dept Internal Med, Hematol Oncol Sect, Shreveport, LA USA.
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- Nishihori, T. (author)
- Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL 33612 USA.
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- Olsson, R. F. (author)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden.
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- Ramanathan, M. (author)
- UMass Mem Med Ctr, Dept Med, Div Hematol Oncol, Worcester, MA USA.
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- Rodriguez, T. E. (author)
- Loyola Univ, Med Ctr, Bone Marrow Transplant Program, Chicago, IL 60611 USA.
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- Saad, A. A. (author)
- Univ Alabama Birmingham, Dept Med, Div Hematol Oncol, Birmingham, AL 35294 USA.
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- Savani, B. N. (author)
- Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.
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- Schiller, G. J. (author)
- Univ Calif Los Angeles, Ctr Hlth Sci, Bone Marrow Transplant Program, Los Angeles, CA 90024 USA.
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- Schouten, H. C. (author)
- Acad Ziekenhuis, Dept Hematol, Maastricht, Netherlands.
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- Schriber, J. R. (author)
- Virginia G Piper Canc Ctr, Canc Transplant Inst, Scottsdale, AZ USA.;Arizona Oncol, Scottsdale, AZ USA.
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- Scott, E. (author)
- Oregon Hlth & Sci Univ, Ctr Hematol Malignancies, Portland, OR 97201 USA.
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- Seo, S. (author)
- Fred Hutchinson Canc Res Ctr, Dept Vaccine & Infect Dis, Seattle, WA 98104 USA.
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- Sharma, M. (author)
- Thomas Jefferson Univ, Dept Hematol Oncol, Philadelphia, PA 19107 USA.
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- Ganguly, S. (author)
- Univ Kansas, Med Ctr, Div Hematol & Oncol, Blood & Marrow Transplantat, Kansas City, KS 66103 USA.
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- Stadtmauer, E. A. (author)
- Univ Penn, Abramson Canc Ctr, Perelman Ctr Adv Med, Div Hematol Oncol, Philadelphia, PA 19104 USA.
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- Tay, J. (author)
- Univ Ottawa, Dept Med, Ottawa, ON, Canada.
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- To, L. B. (author)
- Royal Adelaide Hosp, SA Pathol, Haematol & Bone Marrow Transplant Unit, Adelaide, SA 5000, Australia.
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- Vesole, D. H. (author)
- Hackensack Univ, Med Ctr, Hackensack, NJ USA.
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- Vogl, D. T. (author)
- Univ Penn, Abramson Canc Ctr, Perelman Ctr Adv Med, Div Hematol Oncol, Philadelphia, PA 19104 USA.
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- Wagner, J. L. (author)
- Thomas Jefferson Univ, Dept Hematol Oncol, Philadelphia, PA 19107 USA.
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- Wirk, B. (author)
- Seattle Canc Care Alliance, Seattle, WA USA.
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- Wood, W. A. (author)
- Univ N Carolina, Dept Med, Div Hematol Oncol, Chapel Hill, NC USA.
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- D'Souza, A. (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA Univ Alabama Birmingham, Dept Med, Div Hematol Oncol, Birmingham, AL 35294 USA. (creator_code:org_t)
- 2015-08-24
- 2015
- English.
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In: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365. ; 50:12, s. 1513-1518
- Related links:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In patients with multiple myeloma (MM) undergoing autologous hematopoietic cell transplantation (auto-HCT), peripheral blood progenitor cells may be collected following mobilization with growth factor alone (GF) or cytotoxic chemotherapy plus GF (CC+GF). It is uncertain whether the method of mobilization affects post-transplant outcomes. We compared these mobilization strategies in a retrospective analysis of 968 patients with MM from the Center for International Blood and Marrow Transplant Research database who received an auto-Ha in the US and Canada between 2007 and 2012. The kinetics of neutrophil engraftment (>= 0.5 x 10(9)/L) was similar between groups (13 vs 13 days, P=0.69) while platelet engraftment (>= 20 x 10(9)/L) was slightly faster with CC+GF (19 vs 18 days, P=0.006). Adjusted 3-year PFS was 43% (95% confidence interval (CI) 38-48) in GF and 40% (95% CI 35-45) in CC+GF, P=0.33. Adjusted 3-year OS was 82% (95% CI 78-86) vs 80% (95% CI 75-84), P=0.43 and adjusted 5-year OS was 62% (95% CI 54-68) vs 60% (95% CI 52-67), P=0.76, for GF and CC+GF, respectively. We conclude that MM patients undergoing auto-Ha have similar outcomes irrespective of the method of mobilization and found no evidence that the addition of chemotherapy to mobilization contributes to disease control.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Uy, G. L.
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Costa, L. J.
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Hari, P. N.
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Zhang, M-J
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Huang, J-X
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Anderson, K. C.
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show more...
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Bredeson, C. N.
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Callander, N. S.
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Cornell, R. F.
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Perez, M. A. D.
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Dispenzieri, A.
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Freytes, C. O.
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Gale, R. P.
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Garfall, A.
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Gertz, M. A.
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Gibson, J.
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Hamadani, M.
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Lazarus, H. M.
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Kalaycio, M. E.
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Kamble, R. T.
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Kharfan-Dabaja, ...
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Krishnan, A. Y.
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Kumar, S. K.
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Kyle, R. A.
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Landau, H. J.
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Lee, C. H.
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Maiolino, A.
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Marks, D. I.
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Mark, T. M.
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Munker, R.
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Nishihori, T.
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Olsson, R. F.
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Ramanathan, M.
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Rodriguez, T. E.
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Saad, A. A.
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Savani, B. N.
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Schiller, G. J.
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Schouten, H. C.
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Schriber, J. R.
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Scott, E.
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Seo, S.
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Sharma, M.
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Ganguly, S.
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Stadtmauer, E. A ...
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Tay, J.
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To, L. B.
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Vesole, D. H.
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Vogl, D. T.
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Wagner, J. L.
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Wirk, B.
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Wood, W. A.
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D'Souza, A.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Bone Marrow Tran ...
- By the university
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Uppsala University
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Karolinska Institutet