Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

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Kovacs, Gabor G. (author)

Aging-related tau astrogliopathy (ARTAG) : harmonized evaluation strategy

Article/chapterEnglish2016

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2015-12-10
Springer Science and Business Media LLC,2016
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LIBRIS-ID:oai:DiVA.org:uu-275556
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-275556URI
https://doi.org/10.1007/s00401-015-1509-xDOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of astroglial tau pathology in the aged brain, facilitating communication among neuropathologists and researchers, and informing interpretation of clinical biomarkers and imaging studies that focus on tau-related indicators.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Aging
ARTAG
Tau astrogliopathy
Tau

Added entries (persons, corporate bodies, meetings, titles ...)

Ferrer, IsidroUniv Barcelona, Bellvitge Univ Hosp, Hosp Llobregat, Inst Neuropathol, Barcelona, Spain.;Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA. (author)
Grinberg, Lea T.Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, Brazil. (author)
Alafuzoff, IrinaUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)irial548 (author)
Attems, JohannesNewcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England. (author)
Budka, HerbertUniv Zurich Hosp, Inst Neuropathol, CH-8091 Zurich, Switzerland. (author)
Cairns, Nigel J.Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA. (author)
Crary, John F.Icahn Sch Med Mt Sinai, Friedman Brain Inst, Dept Pathol, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Ronald M Loeb Ctr Alzheimers Dis, New York, NY 10029 USA. (author)
Duyckaerts, CharlesUniv Paris 04, UPMC, Hop La Salpetriere, AP HP,Neuropathol Dept, Paris, France. (author)
Ghetti, BernardinoIndiana Univ, Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46204 USA. (author)
Halliday, Glenda M.GMH Neurosci Res Australia, Sydney, NSW, Australia.;Univ New S Wales, Sydney, NSW, Australia. (author)
Ironside, James W.Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland. (author)
Love, SethUniv Bristol, Southmead Hosp, Inst Clin Neurosci, Bristol, Avon, England. (author)
Mackenzie, Ian R.Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada. (author)
Munoz, David G.St Michaels Hosp, Div Pathol, Toronto, ON M5B 1W8, Canada. (author)
Murray, Melissa E.Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA. (author)
Nelson, Peter T.Univ Kentucky, Dept Pathol, Lexington, KY 40536 USA.;Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA. (author)
Takahashi, HitoshiNiigata Univ, Dept Pathol, Brain Res Inst, Niigata 9518585, Japan. (author)
Trojanowski, John Q.Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis Res,Inst Aging, Philadelphia, PA 19104 USA. (author)
Ansorge, OlafJohn Radcliffe Hosp, Dept Neuropathol, Oxford OX3 9DU, England. (author)
Arzberger, ThomasUniv Munich, Dept Psychiat & Psychotherapy, Ctr Neuropathol & Prion Res, Munich, Germany. (author)
Baborie, AtikWalton Ctr, Dept Neuropathol, Liverpool, Merseyside, England. (author)
Beach, Thomas G.Banner Sun Hlth Res Inst, Civin Lab Neuropathol, Sun City, AZ 85351 USA. (author)
Bieniek, Kevin F.Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA. (author)
Bigio, Eileen H.Northwestern Univ, Feinberg Sch Med, Northwestern ADC Neuropathol Core, Chicago, IL 60611 USA. (author)
Bodi, IstvanKings Coll Hosp London, London Neurodegenerat Brain Bank, Clin Neuropathol, London, England. (author)
Dugger, Brittany N.Banner Sun Hlth Res Inst, Civin Lab Neuropathol, Sun City, AZ 85351 USA.;Univ Calif San Francisco, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA. (author)
Feany, MelHarvard Univ, Sch Med, Brigham & Womens Hosp, Dept Pathol, Boston, MA USA. (author)
Gelpi, EllenBiobank Hosp Clin IDIBAPS, Inst Invest Biomed August Pi & Sunyer, Neurol Tissue Bank, Barcelona, Spain. (author)
Gentleman, Stephen M.Univ London Imperial Coll Sci Technol & Med, Dept Med, London, England. (author)
Giaccone, GiorgioIRCCS Fdn Carlo Besta Neurol Inst, Milan, Italy. (author)
Hatanpaa, Kimmo J.Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA. (author)
Heale, RichardNewcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England. (author)
Hof, Patrick R.Icahn Sch Med Mt Sinai, Ronald M Loeb Ctr Alzheimers Dis, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Friedman Brain Inst, Fishberg Dept Neurosci, New York, NY 10029 USA. (author)
Hofer, MonikaJohn Radcliffe Hosp, Dept Neuropathol, Oxford OX3 9DU, England. (author)
Hortobagyi, TiborUniv Debrecen, Fac Med, Inst Pathol, Dept Neuropathol, H-4032 Debrecen, Hungary. (author)
Jellinger, KurtInst Clin Neurobiol, A-1150 Vienna, Austria. (author)
Jicha, Gregory A.Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA.;Univ Kentucky, Dept Neurol, Lexington, KY 40536 USA. (author)
Ince, PaulUniv Sheffield, Sheffield Inst Translat Neurosci, Sheffield, S Yorkshire, England. (author)
Kofler, JuliaUniv Pittsburgh, Dept Pathol, Pittsburgh, PA USA. (author)
Koevari, EnikoeUniv Hosp, Dept Mental Hlth & Psychiat, Geneva, Switzerland.;Univ Geneva, Sch Med, Geneva, Switzerland. (author)
Kril, Jillian J.Univ Sydney, Sydney Med Sch, Discipline Pathol, Sydney, NSW 2006, Australia. (author)
Mann, David M.Univ Manchester, Fac Med & Hlth Sci, Inst Brain Behav & Mental Hlth, Manchester, Lancs, England. (author)
Matej, RadoslavThomayer Hosp, Dept Pathol & Mol Med, Prague 4, Czech Republic. (author)
McKee, Ann C.Boston Univ, Sch Med & VA Healthcare Syst, Dept Neurol & Pathol, Boston, MA 02118 USA. (author)
McLean, CatrionaAlfred Hosp, Dept Anat Pathol, Prahran, Vic 3004, Australia. (author)
Milenkovic, IvanMed Univ Vienna, Neurol, A-1097 Vienna, Austria.;Med Univ Vienna, Dept Neurol, Vienna, Austria. (author)
Montine, Thomas J.Univ Washington, Dept Pathol, Seattle, WA 98195 USA. (author)
Murayama, ShigeoTokyo Metropolitan Geriatr Hosp, Dept Neuropathol, Brain Bank Aging Res, Tokyo 173, Japan.;Inst Gerontol, Tokyo, Japan. (author)
Lee, Edward B.Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis Res,Inst Aging, Philadelphia, PA 19104 USA. (author)
Rahimi, JasminMed Univ Vienna, Neurol, A-1097 Vienna, Austria. (author)
Rodriguez, Roberta D.Univ Sao Paulo, Sch Med, Brazilian Aging Brain Study Grp LIM22, Physiopathol Aging Lab, Sao Paulo, Brazil. (author)
Rozemuller, AnnemiekeVrije Univ Amsterdam, Med Ctr, Netherlands Brainbank, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, Dept Pathol, Amsterdam, Netherlands. (author)
Schneider, Julie A.Rush Univ, Med Ctr, Dept Pathol, Chicago, IL 60612 USA.;Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA. (author)
Schultz, ChristianHeidelberg Univ, Ctr Biomed & Med Technol Mannheim, Inst Neuroanat, Heidelberg, Germany.;Heidelberg Univ, Med Fac Mannheim, Heidelberg, Germany. (author)
Seeley, WilliamUniv Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA. (author)
Seilhean, DanielleUniv Paris 04, UPMC, Hop La Salpetriere, AP HP,Neuropathol Dept, Paris, France. (author)
Smith, ColinUniv Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland. (author)
Tagliavini, FabrizioIRCCS Fdn Carlo Besta Neurol Inst, Milan, Italy. (author)
Takao, MasakiSaitama Med Univ, Int Med Ctr, Dept Neurol, Saitama, Japan. (author)
Thal, Dietmar RudolfUniv Ulm, Inst Pathol, Neuropathol Lab, D-89081 Ulm, Germany.;Katholieke Univ Leuven, Dept Neurosci, B-3000 Louvain, Belgium. (author)
Toledo, Jon B.Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis Res,Inst Aging, Philadelphia, PA 19104 USA. (author)
Tolnay, MarkusUniv Basel Hosp, Inst Pathol, CH-4031 Basel, Switzerland. (author)
Troncoso, Juan C.Johns Hopkins Univ, Sch Med, Dept Pathol, Div Neuropathol, Baltimore, MD 21205 USA. (author)
Vinters, Harry V.Univ Calif Los Angeles, Med Ctr, Brain Res Inst, Sect Neuropathol,Dept Pathol & Lab Med, Los Angeles, CA 90024 USA.;Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.;Univ Calif Los Angeles, Med Ctr, Brain Res Inst, Dept Neurol, Los Angeles, CA 90095 USA. (author)
Weis, SergeJohannes Kepler Univ Linz, Kepler Univ Hosp, Sch Med, Dept Pathol & Neuropathol,Lab Neuropathol, A-4040 Linz, Austria. (author)
Wharton, Stephen B.Univ Sheffield, Sheffield Inst Translat Neurosci, Sheffield, S Yorkshire, England. (author)
White, Charles L., IIIUniv Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA. (author)
Wisniewski, ThomasNYU, Sch Med, Dept Neurol, Ctr Cognit Neurol, New York, NY 10016 USA.;NYU, Sch Med, Dept Pathol, Ctr Cognit Neurol, New York, NY 10016 USA.;NYU, Sch Med, Dept Psychiat, Ctr Cognit Neurol, New York, NY 10016 USA. (author)
Woulfe, John M.Univ Ottawa, Ottawa Hosp, Res Inst, Dept Pathol & Lab Med,Ctr Canc Therapeut, Ottawa, ON, Canada. (author)
Yamada, MasahitoKanazawa Univ, Grad Sch Med Sci, Dept Neurol & Neurobiol Aging, Kanazawa, Ishikawa, Japan. (author)
Dickson, Dennis W.Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA. (author)
Univ Barcelona, Bellvitge Univ Hosp, Hosp Llobregat, Inst Neuropathol, Barcelona, Spain.;Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA.Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, Brazil. (creator_code:org_t)

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In:Acta Neuropathologica: Springer Science and Business Media LLC131:1, s. 87-1020001-63221432-0533

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By the author/editor: Kovacs, Gabor G.; Ferrer, Isidro; Grinberg, Lea T.; Alafuzoff, Irina; Attems, Johannes; Budka, Herbert; show more...; Cairns, Nigel J.; Crary, John F.; Duyckaerts, Char ...; Ghetti, Bernardi ...; Halliday, Glenda ...; Ironside, James ...; Love, Seth; Mackenzie, Ian R ...; Munoz, David G.; Murray, Melissa ...; Nelson, Peter T.; Takahashi, Hitos ...; Trojanowski, Joh ...; Ansorge, Olaf; Arzberger, Thoma ...; Baborie, Atik; Beach, Thomas G.; Bieniek, Kevin F ...; Bigio, Eileen H.; Bodi, Istvan; Dugger, Brittany ...; Feany, Mel; Gelpi, Ellen; Gentleman, Steph ...; Giaccone, Giorgi ...; Hatanpaa, Kimmo ...; Heale, Richard; Hof, Patrick R.; Hofer, Monika; Hortobagyi, Tibo ...; Jellinger, Kurt; Jicha, Gregory A ...; Ince, Paul; Kofler, Julia; Koevari, Enikoe; Kril, Jillian J.; Mann, David M.; Matej, Radoslav; McKee, Ann C.; McLean, Catriona; Milenkovic, Ivan; Montine, Thomas ...; Murayama, Shigeo; Lee, Edward B.; Rahimi, Jasmin; Rodriguez, Rober ...; Rozemuller, Anne ...; Schneider, Julie ...; Schultz, Christi ...; Seeley, William; Seilhean, Daniel ...; Smith, Colin; Tagliavini, Fabr ...; Takao, Masaki; Thal, Dietmar Ru ...; Toledo, Jon B.; Tolnay, Markus; Troncoso, Juan C ...; Vinters, Harry V ...; Weis, Serge; Wharton, Stephen ...; White, Charles L ...; Wisniewski, Thom ...; Woulfe, John M.; Yamada, Masahito; Dickson, Dennis ...; show less...

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