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Sökning: WFRF:(Gaarenstroom K. N.) > Clinical Use of Can...

  • Soletormos, GyorgyUniv Copenhagen, North Zealand Hosp, Dept Clin Biochem, DK-3400 Hillerod, Denmark. (författare)

Clinical Use of Cancer Biomarkers in Epithelial Ovarian Cancer Updated Guidelines From the European Group on Tumor Markers

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • 2016
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-275569
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-275569URI
  • https://doi.org/10.1097/IGC.0000000000000586DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objective:To present an update of the European Group on Tumor Markers guidelines for serum markers in epithelial varian cancer. Methods: Systematic literature survey from 2008 to 2013. The articles were evaluated by level of evidence and strength of recommendation. Results: Because of its low sensitivity (50-62% for early stage epithelial ovarian cancer) and limited specificity (94-98.5%), cancer antigen (CA) 125 (CA125) is not recommended as a screening test in asymptomatic women. The Risk of Malignancy Index, which includes CA125, transvaginal ultrasound, and menopausal status, is recommended for the differential diagnosis of a pelvic mass. Because human epididymis protein 4 has been reported to have superior specificity to CA125, especially in premenopausal women, it may be considered either alone or as part of the risk of ovarian malignancy algorithm, in the differential diagnosis of pelvic masses, especially in such women. CA125 should be used to monitor response to first-line chemotherapy using the previously published criteria of the Gynecological Cancer Intergroup, that is, at least a 50% reduction of a pretreatment sample of 70 kU/L or greater. The value of CA125 in posttherapy surveillance is less clear. Although a prospective randomized trial concluded that early administration of chemotherapy based on increasing CA125 levels had no effect on survival, European Group on Tumor Markers state that monitoring with CA125 in this situation should occur, especially if the patient is a candidate for secondary cytoreductive surgery. Conclusions: At present, CA125 remains the most important biomarker for epithelial ovarian cancer, excluding tumors of mucinous origin.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Duffy, Michael J.St Vincents Univ Hosp, Clin Res Ctr, Dublin 4, Ireland.;Univ Coll Dublin, UCD Sch Med & Med Sci, Conway Inst Bimol & Biomed, Res, Dublin 2, Ireland. (författare)
  • Abu Hassan, Suher OthmanUniv Copenhagen, North Zealand Hosp, Dept Clin Biochem, DK-3400 Hillerod, Denmark. (författare)
  • Verheijen, Rene H. M.Univ Med, Ctr Utrecht, Dept Gynecol Oncol, Utrecht, Netherlands. (författare)
  • Tholander, BengtUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)betho227 (författare)
  • Bast, Robert C., Jr.Univ Texas MD Anderson Canc Ctr, Div Canc Med, Dept Gynecol Med Oncol, Houston, TX 77030 USA. (författare)
  • Gaarenstroom, Katja N.Leiden Univ, Med Ctr, Dept Gynecol, Leiden, Netherlands. (författare)
  • Sturgeon, Catharine M.Royal Infirm Edinburgh NHS Trust, Dept Clin Biochem, Edinburgh, Midlothian, Scotland. (författare)
  • Bonfrer, Johannes M.PUM Netherlands Senior Experts, Senior Expert Clin Labs, Heemstede, Netherlands. (författare)
  • Petersen, Per HyltoftUniv Bergen, Norwegian Qual Improvement Primary Care Labs NOKL, Sect Gen Practice, Bergen, Norway. (författare)
  • Troonen, HugoAbbott, Limburg, Germany. (författare)
  • CarloTorre, GianCtr Ippocrate, Bogliasco, Italy. (författare)
  • Kulpa, Jan KantyM Sklodowska Curie Mem Inst, Cracow Div, Ctr Oncol, Dept Clin Biochem, Krakow, Poland. (författare)
  • Tuxen, Malgorzata K.Univ Copenhagen, Herlev Hosp, Dept Oncol, DK-2730 Herlev, Denmark. (författare)
  • Molina, RaphaelHosp Clin Barcelona, Biochem Lab, Barcelona, Spain. (författare)
  • Univ Copenhagen, North Zealand Hosp, Dept Clin Biochem, DK-3400 Hillerod, Denmark.St Vincents Univ Hosp, Clin Res Ctr, Dublin 4, Ireland.;Univ Coll Dublin, UCD Sch Med & Med Sci, Conway Inst Bimol & Biomed, Res, Dublin 2, Ireland. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Gynecological Cancer26:1, s. 43-511048-891X1525-1438

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