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New loci for body f...
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
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Lu, Yingchang (author)
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Day, Felix R (author)
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- Gustafsson, Stefan (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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show more...
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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Na, Jianbo (author)
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Bataille, Veronique (author)
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Cousminer, Diana L (author)
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Dastani, Zari (author)
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Drong, Alexander W (author)
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Esko, Tõnu (author)
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Evans, David M (author)
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Falchi, Mario (author)
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Feitosa, Mary F (author)
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Ferreira, Teresa (author)
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- Hedman, Åsa K (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab
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Haring, Robin (author)
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Hysi, Pirro G (author)
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Iles, Mark M (author)
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Justice, Anne E (author)
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Kanoni, Stavroula (author)
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Lagou, Vasiliki (author)
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Li, Rui (author)
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Li, Xin (author)
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Locke, Adam (author)
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Lu, Chen (author)
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Mägi, Reedik (author)
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Perry, John R B (author)
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Pers, Tune H (author)
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Qi, Qibin (author)
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Sanna, Marianna (author)
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Schmidt, Ellen M (author)
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Scott, William R (author)
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- Shungin, Dmitry (author)
- Lund University,Lunds universitet,Umeå universitet,Medicin,Institutionen för odontologi,Lund University Diabetes Centre, Department of Clinical Science, Genetic and Molecular Epidemiology Unit, Skåne University Hosptial, 205 02 Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Teumer, Alexander (author)
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Vinkhuyzen, Anna A E (author)
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Walker, Ryan W (author)
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Westra, Harm-Jan (author)
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Zhang, Mingfeng (author)
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Zhang, Weihua (author)
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Zhao, Jing Hua (author)
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Zhu, Zhihong (author)
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Afzal, Uzma (author)
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Ahluwalia, Tarunveer Singh (author)
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Bakker, Stephan J L (author)
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Bellis, Claire (author)
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Bonnefond, Amélie (author)
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Borodulin, Katja (author)
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Buchman, Aron S (author)
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- Cederholm, Tommy (author)
- Karolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism
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Choh, Audrey C (author)
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Choi, Hyung Jin (author)
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Curran, Joanne E (author)
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de Groot, Lisette C P G M (author)
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De Jager, Philip L (author)
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Dhonukshe-Rutten, Rosalie A M (author)
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Enneman, Anke W (author)
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Eury, Elodie (author)
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Evans, Daniel S (author)
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Forsen, Tom (author)
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Friedrich, Nele (author)
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Fumeron, Frédéric (author)
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Garcia, Melissa E (author)
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Gärtner, Simone (author)
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Han, Bok-Ghee (author)
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Havulinna, Aki S (author)
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Hayward, Caroline (author)
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Hernandez, Dena (author)
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Hillege, Hans (author)
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Ittermann, Till (author)
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Kent, Jack W (author)
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Kolcic, Ivana (author)
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Laatikainen, Tiina (author)
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Lahti, Jari (author)
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Mateo Leach, Irene (author)
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Lee, Christine G (author)
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Lee, Jong-Young (author)
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Liu, Tian (author)
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Liu, Youfang (author)
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Lobbens, Stéphane (author)
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Loh, Marie (author)
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Lyytikäinen, Leo-Pekka (author)
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Medina-Gomez, Carolina (author)
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- Michaëlsson, Karl (author)
- Uppsala universitet,Ortopedi
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Nalls, Mike A (author)
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Nielson, Carrie M (author)
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Oozageer, Laticia (author)
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Pascoe, Laura (author)
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Paternoster, Lavinia (author)
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Polašek, Ozren (author)
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Ripatti, Samuli (author)
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Sarzynski, Mark A (author)
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Shin, Chan Soo (author)
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Narančić, Nina Smolej (author)
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Spira, Dominik (author)
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Srikanth, Priya (author)
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Steinhagen-Thiessen, Elisabeth (author)
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Sung, Yun Ju (author)
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Swart, Karin M A (author)
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Taittonen, Leena (author)
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Tanaka, Toshiko (author)
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Tikkanen, Emmi (author)
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van der Velde, Nathalie (author)
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van Schoor, Natasja M (author)
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Verweij, Niek (author)
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Wright, Alan F (author)
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Yu, Lei (author)
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Zmuda, Joseph M (author)
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Eklund, Niina (author)
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Forrester, Terrence (author)
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Grarup, Niels (author)
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Jackson, Anne U (author)
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Kristiansson, Kati (author)
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Kuulasmaa, Teemu (author)
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Kuusisto, Johanna (author)
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Lichtner, Peter (author)
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Luan, Jian'an (author)
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Mahajan, Anubha (author)
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Männistö, Satu (author)
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Palmer, Cameron D (author)
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Ried, Janina S (author)
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Scott, Robert A (author)
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Stancáková, Alena (author)
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Wagner, Peter J (author)
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Demirkan, Ayse (author)
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Döring, Angela (author)
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Gudnason, Vilmundur (author)
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Kiel, Douglas P (author)
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Kühnel, Brigitte (author)
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Mangino, Massimo (author)
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Mcknight, Barbara (author)
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Menni, Cristina (author)
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O'Connell, Jeffrey R (author)
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Oostra, Ben A (author)
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Shuldiner, Alan R (author)
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Song, Kijoung (author)
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- Vandenput, Liesbeth, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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van Duijn, Cornelia M (author)
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Vollenweider, Peter (author)
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White, Charles C (author)
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Boehnke, Michael (author)
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Boettcher, Yvonne (author)
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Cooper, Richard S (author)
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Forouhi, Nita G (author)
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Gieger, Christian (author)
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Grallert, Harald (author)
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Hingorani, Aroon (author)
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Jørgensen, Torben (author)
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Jousilahti, Pekka (author)
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Kivimaki, Mika (author)
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Kumari, Meena (author)
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Laakso, Markku (author)
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Langenberg, Claudia (author)
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Linneberg, Allan (author)
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Luke, Amy (author)
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Mckenzie, Colin A (author)
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Palotie, Aarno (author)
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Pedersen, Oluf (author)
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Peters, Annette (author)
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Strauch, Konstantin (author)
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Tayo, Bamidele O (author)
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Wareham, Nicholas J (author)
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Bennett, David A (author)
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Bertram, Lars (author)
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Blangero, John (author)
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Blüher, Matthias (author)
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Bouchard, Claude (author)
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Campbell, Harry (author)
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Cho, Nam H (author)
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Cummings, Steven R (author)
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Czerwinski, Stefan A (author)
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Demuth, Ilja (author)
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Eckardt, Rahel (author)
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Eriksson, Johan G (author)
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Ferrucci, Luigi (author)
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Franco, Oscar H (author)
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Froguel, Philippe (author)
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Gansevoort, Ron T (author)
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Hansen, Torben (author)
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Harris, Tamara B (author)
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Hastie, Nicholas (author)
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Heliövaara, Markku (author)
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Hofman, Albert (author)
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Jordan, Joanne M (author)
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Jula, Antti (author)
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Kähönen, Mika (author)
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Kajantie, Eero (author)
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Knekt, Paul B (author)
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Koskinen, Seppo (author)
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Kovacs, Peter (author)
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Lehtimäki, Terho (author)
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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Liu, Yongmei (author)
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Orwoll, Eric S (author)
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Osmond, Clive (author)
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Perola, Markus (author)
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Pérusse, Louis (author)
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Raitakari, Olli T (author)
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Rankinen, Tuomo (author)
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Rao, D C (author)
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Rice, Treva K (author)
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Rivadeneira, Fernando (author)
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Rudan, Igor (author)
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Salomaa, Veikko (author)
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Sørensen, Thorkild I A (author)
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Stumvoll, Michael (author)
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Tönjes, Anke (author)
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Towne, Bradford (author)
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Tranah, Gregory J (author)
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Tremblay, Angelo (author)
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Uitterlinden, André G (author)
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van der Harst, Pim (author)
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Vartiainen, Erkki (author)
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Viikari, Jorma S (author)
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Vitart, Veronique (author)
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Vohl, Marie-Claude (author)
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Völzke, Henry (author)
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Walker, Mark (author)
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Wallaschofski, Henri (author)
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Wild, Sarah (author)
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Wilson, James F (author)
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Yengo, Loïc (author)
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Bishop, D Timothy (author)
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Borecki, Ingrid B (author)
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Chambers, John C (author)
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Cupples, L Adrienne (author)
-
Dehghan, Abbas (author)
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Deloukas, Panos (author)
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Fatemifar, Ghazaleh (author)
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Fox, Caroline (author)
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Furey, Terrence S (author)
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Franke, Lude (author)
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Han, Jiali (author)
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Hunter, David J (author)
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Karjalainen, Juha (author)
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Karpe, Fredrik (author)
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Kaplan, Robert C (author)
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Kooner, Jaspal S (author)
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McCarthy, Mark I (author)
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Murabito, Joanne M (author)
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Morris, Andrew P (author)
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Bishop, Julia A N (author)
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North, Kari E (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Ong, Ken K (author)
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Prokopenko, Inga (author)
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Richards, J Brent (author)
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Schadt, Eric E (author)
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Spector, Tim D (author)
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Widén, Elisabeth (author)
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Willer, Cristen J (author)
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Yang, Jian (author)
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- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi
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Mohlke, Karen L (author)
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Hirschhorn, Joel N (author)
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Pospisilik, John Andrew (author)
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Zillikens, M Carola (author)
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Lindgren, Cecilia (author)
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Kilpeläinen, Tuomas Oskari (author)
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Loos, Ruth J F (author)
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(creator_code:org_t)
- 2016-02-01
- 2016
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
- Related links:
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http://www.ncbi.nlm.... (free)
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Keyword
- C reactive protein; CRTC1 protein; glucose; GRB14 protein; high density lipoprotein cholesterol; IGF2BP1 protein; insulin; leptin; low density lipoprotein cholesterol; PLA2G6 protein; protein; triacylglycerol; unclassified drug
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Lu, Yingchang
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Day, Felix R
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Gustafsson, Stef ...
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Lind, Lars
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Na, Jianbo
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Bataille, Veroni ...
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show more...
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Cousminer, Diana ...
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Dastani, Zari
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Drong, Alexander ...
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Esko, Tõnu
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Evans, David M
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Falchi, Mario
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Feitosa, Mary F
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Ferreira, Teresa
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Hedman, Åsa K
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Haring, Robin
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Hysi, Pirro G
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Iles, Mark M
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Justice, Anne E
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Kanoni, Stavroul ...
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Lagou, Vasiliki
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Li, Rui
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Li, Xin
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Locke, Adam
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Lu, Chen
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Mägi, Reedik
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Perry, John R B
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Pers, Tune H
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Qi, Qibin
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Sanna, Marianna
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Schmidt, Ellen M
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Scott, William R
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Shungin, Dmitry
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Teumer, Alexande ...
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Vinkhuyzen, Anna ...
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Walker, Ryan W
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Westra, Harm-Jan
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Zhang, Mingfeng
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Zhang, Weihua
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Zhao, Jing Hua
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Zhu, Zhihong
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Afzal, Uzma
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Ahluwalia, Tarun ...
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Bakker, Stephan ...
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Bellis, Claire
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Bonnefond, Améli ...
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Borodulin, Katja
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Buchman, Aron S
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Cederholm, Tommy
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Choh, Audrey C
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Choi, Hyung Jin
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Curran, Joanne E
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de Groot, Lisett ...
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De Jager, Philip ...
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Dhonukshe-Rutten ...
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Enneman, Anke W
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Eury, Elodie
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Evans, Daniel S
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Forsen, Tom
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Friedrich, Nele
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Fumeron, Frédéri ...
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Garcia, Melissa ...
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Gärtner, Simone
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Han, Bok-Ghee
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Havulinna, Aki S
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Hayward, Carolin ...
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Hernandez, Dena
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Hillege, Hans
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Ittermann, Till
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Kent, Jack W
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Kolcic, Ivana
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Laatikainen, Tii ...
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Lahti, Jari
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Mateo Leach, Ire ...
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Lee, Christine G
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Lee, Jong-Young
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Liu, Tian
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Liu, Youfang
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Lobbens, Stéphan ...
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Loh, Marie
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Lyytikäinen, Leo ...
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Medina-Gomez, Ca ...
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Michaëlsson, Kar ...
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Nalls, Mike A
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Nielson, Carrie ...
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Oozageer, Latici ...
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Pascoe, Laura
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Paternoster, Lav ...
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Polašek, Ozren
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Ripatti, Samuli
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Sarzynski, Mark ...
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Shin, Chan Soo
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Narančić, Nina S ...
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Spira, Dominik
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Srikanth, Priya
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Steinhagen-Thies ...
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Sung, Yun Ju
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Swart, Karin M A
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Taittonen, Leena
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Tanaka, Toshiko
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Tikkanen, Emmi
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van der Velde, N ...
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van Schoor, Nata ...
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Verweij, Niek
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Wright, Alan F
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Yu, Lei
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Zmuda, Joseph M
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Eklund, Niina
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Forrester, Terre ...
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Grarup, Niels
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Jackson, Anne U
-
Kristiansson, Ka ...
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Kuulasmaa, Teemu
-
Kuusisto, Johann ...
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Lichtner, Peter
-
Luan, Jian'an
-
Mahajan, Anubha
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Männistö, Satu
-
Palmer, Cameron ...
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Ried, Janina S
-
Scott, Robert A
-
Stancáková, Alen ...
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Wagner, Peter J
-
Demirkan, Ayse
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Döring, Angela
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Gudnason, Vilmun ...
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Kiel, Douglas P
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Kühnel, Brigitte
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Mangino, Massimo
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Mcknight, Barbar ...
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Menni, Cristina
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O'Connell, Jeffr ...
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Oostra, Ben A
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Shuldiner, Alan ...
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Song, Kijoung
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Vandenput, Liesb ...
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van Duijn, Corne ...
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Vollenweider, Pe ...
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White, Charles C
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Boehnke, Michael
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Boettcher, Yvonn ...
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Cooper, Richard ...
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Forouhi, Nita G
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Gieger, Christia ...
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Grallert, Harald
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Hingorani, Aroon
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Jørgensen, Torbe ...
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Jousilahti, Pekk ...
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Kivimaki, Mika
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Kumari, Meena
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Laakso, Markku
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Langenberg, Clau ...
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Linneberg, Allan
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Luke, Amy
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Mckenzie, Colin ...
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Palotie, Aarno
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Pedersen, Oluf
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Peters, Annette
-
Strauch, Konstan ...
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Tayo, Bamidele O
-
Wareham, Nichola ...
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Bennett, David A
-
Bertram, Lars
-
Blangero, John
-
Blüher, Matthias
-
Bouchard, Claude
-
Campbell, Harry
-
Cho, Nam H
-
Cummings, Steven ...
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Czerwinski, Stef ...
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Demuth, Ilja
-
Eckardt, Rahel
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Eriksson, Johan ...
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Ferrucci, Luigi
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Franco, Oscar H
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Froguel, Philipp ...
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Gansevoort, Ron ...
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Hansen, Torben
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Harris, Tamara B
-
Hastie, Nicholas
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Heliövaara, Mark ...
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Hofman, Albert
-
Jordan, Joanne M
-
Jula, Antti
-
Kähönen, Mika
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Kajantie, Eero
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Knekt, Paul B
-
Koskinen, Seppo
-
Kovacs, Peter
-
Lehtimäki, Terho
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Liu, Yongmei
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Orwoll, Eric S
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Osmond, Clive
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Perola, Markus
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Pérusse, Louis
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Raitakari, Olli ...
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Rankinen, Tuomo
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Rao, D C
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Rice, Treva K
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Rivadeneira, Fer ...
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Rudan, Igor
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Salomaa, Veikko
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Sørensen, Thorki ...
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Stumvoll, Michae ...
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Tönjes, Anke
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Towne, Bradford
-
Tranah, Gregory ...
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Tremblay, Angelo
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Uitterlinden, An ...
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van der Harst, P ...
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Vartiainen, Erkk ...
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Viikari, Jorma S
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Vitart, Veroniqu ...
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Vohl, Marie-Clau ...
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Völzke, Henry
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Walker, Mark
-
Wallaschofski, H ...
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Wild, Sarah
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Wilson, James F
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Yengo, Loïc
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Bishop, D Timoth ...
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Borecki, Ingrid ...
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Chambers, John C
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Cupples, L Adrie ...
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Dehghan, Abbas
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Deloukas, Panos
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Fatemifar, Ghaza ...
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Fox, Caroline
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Furey, Terrence ...
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Franke, Lude
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Han, Jiali
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Hunter, David J
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Karjalainen, Juh ...
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Karpe, Fredrik
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Kaplan, Robert C
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Kooner, Jaspal S
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McCarthy, Mark I
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Murabito, Joanne ...
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Morris, Andrew P
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Bishop, Julia A ...
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North, Kari E
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Ohlsson, Claes, ...
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Ong, Ken K
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Prokopenko, Inga
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Richards, J Bren ...
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Schadt, Eric E
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Spector, Tim D
-
Widén, Elisabeth
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Willer, Cristen ...
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Yang, Jian
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Ingelsson, Erik
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Mohlke, Karen L
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Hirschhorn, Joel ...
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Pospisilik, John ...
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Zillikens, M Car ...
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Lindgren, Cecili ...
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Kilpeläinen, Tuo ...
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Loos, Ruth J F
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- By the university
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Uppsala University
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Umeå University
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Lund University
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Karolinska Institutet
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University of Gothenburg