New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

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Lu, Yingchang (author)

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Article/chapterEnglish2016

Publisher, publication year, extent ...

2016-02-01
Springer Science and Business Media LLC,2016
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-275672
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-275672URI
https://doi.org/10.1038/ncomms10495DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118411URI
https://lup.lub.lu.se/record/8829541URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:133058788URI
https://gup.ub.gu.se/publication/243491URI

Supplementary language notes

Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Näringslära hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Nutrition and Dietetics hsv//eng
NATURVETENSKAP Biologi Genetik hsv//swe
NATURAL SCIENCES Biological Sciences Genetics hsv//eng
C reactive protein; CRTC1 protein; glucose; GRB14 protein; high density lipoprotein cholesterol; IGF2BP1 protein; insulin; leptin; low density lipoprotein cholesterol; PLA2G6 protein; protein; triacylglycerol; unclassified drug

Added entries (persons, corporate bodies, meetings, titles ...)

Day, Felix R (author)
Gustafsson, StefanUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)stegu732 (author)
Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
Na, Jianbo (author)
Bataille, Veronique (author)
Cousminer, Diana L (author)
Dastani, Zari (author)
Drong, Alexander W (author)
Esko, Tõnu (author)
Evans, David M (author)
Falchi, Mario (author)
Feitosa, Mary F (author)
Ferreira, Teresa (author)
Hedman, Åsa KUppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab(Swepub:uu)ashed124 (author)
Haring, Robin (author)
Hysi, Pirro G (author)
Iles, Mark M (author)
Justice, Anne E (author)
Kanoni, Stavroula (author)
Lagou, Vasiliki (author)
Li, Rui (author)
Li, Xin (author)
Locke, Adam (author)
Lu, Chen (author)
Mägi, Reedik (author)
Perry, John R B (author)
Pers, Tune H (author)
Qi, Qibin (author)
Sanna, Marianna (author)
Schmidt, Ellen M (author)
Scott, William R (author)
Shungin, DmitryLund University,Lunds universitet,Umeå universitet,Medicin,Institutionen för odontologi,Lund University Diabetes Centre, Department of Clinical Science, Genetic and Molecular Epidemiology Unit, Skåne University Hosptial, 205 02 Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-dsn (author)
Teumer, Alexander (author)
Vinkhuyzen, Anna A E (author)
Walker, Ryan W (author)
Westra, Harm-Jan (author)
Zhang, Mingfeng (author)
Zhang, Weihua (author)
Zhao, Jing Hua (author)
Zhu, Zhihong (author)
Afzal, Uzma (author)
Ahluwalia, Tarunveer Singh (author)
Bakker, Stephan J L (author)
Bellis, Claire (author)
Bonnefond, Amélie (author)
Borodulin, Katja (author)
Buchman, Aron S (author)
Cederholm, TommyKarolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)tomce419 (author)
Choh, Audrey C (author)
Choi, Hyung Jin (author)
Curran, Joanne E (author)
de Groot, Lisette C P G M (author)
De Jager, Philip L (author)
Dhonukshe-Rutten, Rosalie A M (author)
Enneman, Anke W (author)
Eury, Elodie (author)
Evans, Daniel S (author)
Forsen, Tom (author)
Friedrich, Nele (author)
Fumeron, Frédéric (author)
Garcia, Melissa E (author)
Gärtner, Simone (author)
Han, Bok-Ghee (author)
Havulinna, Aki S (author)
Hayward, Caroline (author)
Hernandez, Dena (author)
Hillege, Hans (author)
Ittermann, Till (author)
Kent, Jack W (author)
Kolcic, Ivana (author)
Laatikainen, Tiina (author)
Lahti, Jari (author)
Mateo Leach, Irene (author)
Lee, Christine G (author)
Lee, Jong-Young (author)
Liu, Tian (author)
Liu, Youfang (author)
Lobbens, Stéphane (author)
Loh, Marie (author)
Lyytikäinen, Leo-Pekka (author)
Medina-Gomez, Carolina (author)
Michaëlsson, KarlUppsala universitet,Ortopedi(Swepub:uu)karlmich (author)
Nalls, Mike A (author)
Nielson, Carrie M (author)
Oozageer, Laticia (author)
Pascoe, Laura (author)
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Polašek, Ozren (author)
Ripatti, Samuli (author)
Sarzynski, Mark A (author)
Shin, Chan Soo (author)
Narančić, Nina Smolej (author)
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Swart, Karin M A (author)
Taittonen, Leena (author)
Tanaka, Toshiko (author)
Tikkanen, Emmi (author)
van der Velde, Nathalie (author)
van Schoor, Natasja M (author)
Verweij, Niek (author)
Wright, Alan F (author)
Yu, Lei (author)
Zmuda, Joseph M (author)
Eklund, Niina (author)
Forrester, Terrence (author)
Grarup, Niels (author)
Jackson, Anne U (author)
Kristiansson, Kati (author)
Kuulasmaa, Teemu (author)
Kuusisto, Johanna (author)
Lichtner, Peter (author)
Luan, Jian'an (author)
Mahajan, Anubha (author)
Männistö, Satu (author)
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Ried, Janina S (author)
Scott, Robert A (author)
Stancáková, Alena (author)
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Demirkan, Ayse (author)
Döring, Angela (author)
Gudnason, Vilmundur (author)
Kiel, Douglas P (author)
Kühnel, Brigitte (author)
Mangino, Massimo (author)
Mcknight, Barbara (author)
Menni, Cristina (author)
O'Connell, Jeffrey R (author)
Oostra, Ben A (author)
Shuldiner, Alan R (author)
Song, Kijoung (author)
Vandenput, Liesbeth,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xvanli (author)
van Duijn, Cornelia M (author)
Vollenweider, Peter (author)
White, Charles C (author)
Boehnke, Michael (author)
Boettcher, Yvonne (author)
Cooper, Richard S (author)
Forouhi, Nita G (author)
Gieger, Christian (author)
Grallert, Harald (author)
Hingorani, Aroon (author)
Jørgensen, Torben (author)
Jousilahti, Pekka (author)
Kivimaki, Mika (author)
Kumari, Meena (author)
Laakso, Markku (author)
Langenberg, Claudia (author)
Linneberg, Allan (author)
Luke, Amy (author)
Mckenzie, Colin A (author)
Palotie, Aarno (author)
Pedersen, Oluf (author)
Peters, Annette (author)
Strauch, Konstantin (author)
Tayo, Bamidele O (author)
Wareham, Nicholas J (author)
Bennett, David A (author)
Bertram, Lars (author)
Blangero, John (author)
Blüher, Matthias (author)
Bouchard, Claude (author)
Campbell, Harry (author)
Cho, Nam H (author)
Cummings, Steven R (author)
Czerwinski, Stefan A (author)
Demuth, Ilja (author)
Eckardt, Rahel (author)
Eriksson, Johan G (author)
Ferrucci, Luigi (author)
Franco, Oscar H (author)
Froguel, Philippe (author)
Gansevoort, Ron T (author)
Hansen, Torben (author)
Harris, Tamara B (author)
Hastie, Nicholas (author)
Heliövaara, Markku (author)
Hofman, Albert (author)
Jordan, Joanne M (author)
Jula, Antti (author)
Kähönen, Mika (author)
Kajantie, Eero (author)
Knekt, Paul B (author)
Koskinen, Seppo (author)
Kovacs, Peter (author)
Lehtimäki, Terho (author)
Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
Liu, Yongmei (author)
Orwoll, Eric S (author)
Osmond, Clive (author)
Perola, Markus (author)
Pérusse, Louis (author)
Raitakari, Olli T (author)
Rankinen, Tuomo (author)
Rao, D C (author)
Rice, Treva K (author)
Rivadeneira, Fernando (author)
Rudan, Igor (author)
Salomaa, Veikko (author)
Sørensen, Thorkild I A (author)
Stumvoll, Michael (author)
Tönjes, Anke (author)
Towne, Bradford (author)
Tranah, Gregory J (author)
Tremblay, Angelo (author)
Uitterlinden, André G (author)
van der Harst, Pim (author)
Vartiainen, Erkki (author)
Viikari, Jorma S (author)
Vitart, Veronique (author)
Vohl, Marie-Claude (author)
Völzke, Henry (author)
Walker, Mark (author)
Wallaschofski, Henri (author)
Wild, Sarah (author)
Wilson, James F (author)
Yengo, Loïc (author)
Bishop, D Timothy (author)
Borecki, Ingrid B (author)
Chambers, John C (author)
Cupples, L Adrienne (author)
Dehghan, Abbas (author)
Deloukas, Panos (author)
Fatemifar, Ghazaleh (author)
Fox, Caroline (author)
Furey, Terrence S (author)
Franke, Lude (author)
Han, Jiali (author)
Hunter, David J (author)
Karjalainen, Juha (author)
Karpe, Fredrik (author)
Kaplan, Robert C (author)
Kooner, Jaspal S (author)
McCarthy, Mark I (author)
Murabito, Joanne M (author)
Morris, Andrew P (author)
Bishop, Julia A N (author)
North, Kari E (author)
Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xohlcl (author)
Ong, Ken K (author)
Prokopenko, Inga (author)
Richards, J Brent (author)
Schadt, Eric E (author)
Spector, Tim D (author)
Widén, Elisabeth (author)
Willer, Cristen J (author)
Yang, Jian (author)
Ingelsson, ErikUppsala universitet,Molekylär epidemiologi(Swepub:uu)ering425 (author)
Mohlke, Karen L (author)
Hirschhorn, Joel N (author)
Pospisilik, John Andrew (author)
Zillikens, M Carola (author)
Lindgren, Cecilia (author)
Kilpeläinen, Tuomas Oskari (author)
Loos, Ruth J F (author)
Uppsala universitetMolekylär epidemiologi (creator_code:org_t)

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By the author/editor: Lu, Yingchang; Day, Felix R; Gustafsson, Stef ...; Lind, Lars; Na, Jianbo; Bataille, Veroni ...; show more...; Cousminer, Diana ...; Dastani, Zari; Drong, Alexander ...; Esko, Tõnu; Evans, David M; Falchi, Mario; Feitosa, Mary F; Ferreira, Teresa; Hedman, Åsa K; Haring, Robin; Hysi, Pirro G; Iles, Mark M; Justice, Anne E; Kanoni, Stavroul ...; Lagou, Vasiliki; Li, Rui; Li, Xin; Locke, Adam; Lu, Chen; Mägi, Reedik; Perry, John R B; Pers, Tune H; Qi, Qibin; Sanna, Marianna; Schmidt, Ellen M; Scott, William R; Shungin, Dmitry; Teumer, Alexande ...; Vinkhuyzen, Anna ...; Walker, Ryan W; Westra, Harm-Jan; Zhang, Mingfeng; Zhang, Weihua; Zhao, Jing Hua; Zhu, Zhihong; Afzal, Uzma; Ahluwalia, Tarun ...; Bakker, Stephan ...; Bellis, Claire; Bonnefond, Améli ...; Borodulin, Katja; Buchman, Aron S; Cederholm, Tommy; Choh, Audrey C; Choi, Hyung Jin; Curran, Joanne E; de Groot, Lisett ...; De Jager, Philip ...; Dhonukshe-Rutten ...; Enneman, Anke W; Eury, Elodie; Evans, Daniel S; Forsen, Tom; Friedrich, Nele; Fumeron, Frédéri ...; Garcia, Melissa ...; Gärtner, Simone; Han, Bok-Ghee; Havulinna, Aki S; Hayward, Carolin ...; Hernandez, Dena; Hillege, Hans; Ittermann, Till; Kent, Jack W; Kolcic, Ivana; Laatikainen, Tii ...; Lahti, Jari; Mateo Leach, Ire ...; Lee, Christine G; Lee, Jong-Young; Liu, Tian; Liu, Youfang; Lobbens, Stéphan ...; Loh, Marie; Lyytikäinen, Leo ...; Medina-Gomez, Ca ...; Michaëlsson, Kar ...; Nalls, Mike A; Nielson, Carrie ...; Oozageer, Latici ...; Pascoe, Laura; Paternoster, Lav ...; Polašek, Ozren; Ripatti, Samuli; Sarzynski, Mark ...; Shin, Chan Soo; Narančić, Nina S ...; Spira, Dominik; Srikanth, Priya; Steinhagen-Thies ...; Sung, Yun Ju; Swart, Karin M A; Taittonen, Leena; Tanaka, Toshiko; Tikkanen, Emmi; van der Velde, N ...; van Schoor, Nata ...; Verweij, Niek; Wright, Alan F; Yu, Lei; Zmuda, Joseph M; Eklund, Niina; Forrester, Terre ...; Grarup, Niels; Jackson, Anne U; Kristiansson, Ka ...; Kuulasmaa, Teemu; Kuusisto, Johann ...; Lichtner, Peter; Luan, Jian'an; Mahajan, Anubha; Männistö, Satu; Palmer, Cameron ...; Ried, Janina S; Scott, Robert A; Stancáková, Alen ...; Wagner, Peter J; Demirkan, Ayse; Döring, Angela; Gudnason, Vilmun ...; Kiel, Douglas P; Kühnel, Brigitte; Mangino, Massimo; Mcknight, Barbar ...; Menni, Cristina; O'Connell, Jeffr ...; Oostra, Ben A; Shuldiner, Alan ...; Song, Kijoung; Vandenput, Liesb ...; van Duijn, Corne ...; Vollenweider, Pe ...; White, Charles C; Boehnke, Michael; Boettcher, Yvonn ...; Cooper, Richard ...; Forouhi, Nita G; Gieger, Christia ...; Grallert, Harald; Hingorani, Aroon; Jørgensen, Torbe ...; Jousilahti, Pekk ...; Kivimaki, Mika; Kumari, Meena; Laakso, Markku; Langenberg, Clau ...; Linneberg, Allan; Luke, Amy; Mckenzie, Colin ...; Palotie, Aarno; Pedersen, Oluf; Peters, Annette; Strauch, Konstan ...; Tayo, Bamidele O; Wareham, Nichola ...; Bennett, David A; Bertram, Lars; Blangero, John; Blüher, Matthias; Bouchard, Claude; Campbell, Harry; Cho, Nam H; Cummings, Steven ...; Czerwinski, Stef ...; Demuth, Ilja; Eckardt, Rahel; Eriksson, Johan ...; Ferrucci, Luigi; Franco, Oscar H; Froguel, Philipp ...; Gansevoort, Ron ...; Hansen, Torben; Harris, Tamara B; Hastie, Nicholas; Heliövaara, Mark ...; Hofman, Albert; Jordan, Joanne M; Jula, Antti; Kähönen, Mika; Kajantie, Eero; Knekt, Paul B; Koskinen, Seppo; Kovacs, Peter; Lehtimäki, Terho; Liu, Yongmei; Orwoll, Eric S; Osmond, Clive; Perola, Markus; Pérusse, Louis; Raitakari, Olli ...; Rankinen, Tuomo; Rao, D C; Rice, Treva K; Rivadeneira, Fer ...; Rudan, Igor; Salomaa, Veikko; Sørensen, Thorki ...; Stumvoll, Michae ...; Tönjes, Anke; Towne, Bradford; Tranah, Gregory ...; Tremblay, Angelo; Uitterlinden, An ...; van der Harst, P ...; Vartiainen, Erkk ...; Viikari, Jorma S; Vitart, Veroniqu ...; Vohl, Marie-Clau ...; Völzke, Henry; Walker, Mark; Wallaschofski, H ...; Wild, Sarah; Wilson, James F; Yengo, Loïc; Bishop, D Timoth ...; Borecki, Ingrid ...; Chambers, John C; Cupples, L Adrie ...; Dehghan, Abbas; Deloukas, Panos; Fatemifar, Ghaza ...; Fox, Caroline; Furey, Terrence ...; Franke, Lude; Han, Jiali; Hunter, David J; Karjalainen, Juh ...; Karpe, Fredrik; Kaplan, Robert C; Kooner, Jaspal S; McCarthy, Mark I; Murabito, Joanne ...; Morris, Andrew P; Bishop, Julia A ...; North, Kari E; Ohlsson, Claes, ...; Ong, Ken K; Prokopenko, Inga; Richards, J Bren ...; Schadt, Eric E; Spector, Tim D; Widén, Elisabeth; Willer, Cristen ...; Yang, Jian; Ingelsson, Erik; Mohlke, Karen L; Hirschhorn, Joel ...; Pospisilik, John ...; Zillikens, M Car ...; Lindgren, Cecili ...; Kilpeläinen, Tuo ...; Loos, Ruth J F; show less...

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