Sökning: L773:0012 1797 OR L773:1939 327X >
Gastric bypass redu...
-
Abrahamsson, Niclas,1976-Uppsala universitet,Klinisk diabetologi och metabolism,Endokrin och Diabetes, prof Jan Eriksson
(författare)
Gastric bypass reduces symptoms and hormonal responses to hypoglycemia
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
-
2016-06-16
-
American Diabetes Association,2016
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-276380
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-276380URI
-
https://doi.org/10.2337/db16-0341DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-126314URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Gastric bypass (GBP) surgery, one of the most common bariatric procedures, induces weight loss and metabolic effects. The mechanisms are not fully understood, but reduced food intake and effects on gastrointestinal hormones are thought to contribute. We recently observed that GBP patients have lowered glucose levels and frequent asymptomatic hypoglycemic episodes. Here, we subjected patients before and after undergoing GBP surgery to hypoglycemia and examined symptoms and hormonal and autonomic nerve responses. Twelve obese patients without diabetes (8 women, mean age 43.1 years [SD 10.8] and BMI 40.6 kg/m(2) [SD 3.1]) were examined before and 23 weeks (range 19-25) after GBP surgery with hyperinsulinemic-hypoglycemic clamp (stepwise to plasma glucose 2.7 mmol/L). The mean change in Edinburgh Hypoglycemia Score during clamp was attenuated from 10.7 (6.4) before surgery to 5.2 (4.9) after surgery. There were also marked postsurgery reductions in levels of glucagon, cortisol, and catecholamine and the sympathetic nerve responses to hypoglycemia. In addition, growth hormone displayed a delayed response but to a higher peak level. Levels of glucagon-like peptide 1 and gastric inhibitory polypeptide rose during hypoglycemia but rose less postsurgery compared with presurgery. Thus, GBP surgery causes a resetting of glucose homeostasis, which reduces symptoms and neurohormonal responses to hypoglycemia. Further studies should address the underlying mechanisms as well as their impact on the overall metabolic effects of GBP surgery.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Lau Börjesson, JoeyUppsala universitet,Klinisk diabetologi och metabolism,Institutionen för medicinsk cellbiologi(Swepub:uu)jolau226
(författare)
-
Sundbom, MagnusUppsala universitet,Gastrointestinalkirurgi(Swepub:uu)magsundb
(författare)
-
Wiklund, UrbanUmeå universitet,Institutionen för strålningsvetenskaper(Swepub:umu)urwi0001
(författare)
-
Karlsson, AndersUppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)anderska
(författare)
-
Eriksson, Jan W.Uppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)janer909
(författare)
-
Uppsala universitetKlinisk diabetologi och metabolism
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Diabetes: American Diabetes Association65:9, s. 2667-26750012-17971939-327X
Internetlänk
Hitta via bibliotek
-
Diabetes
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas