WFRF:(Nistér Monica)
Search: WFRF:(Nistér Monica) > (2015-2019) > Improving the Predi...
- 3 of 3
- Previous record
- Next record
- To hitlist
- Peng, ZhuochunKarolinska Institutet (author)
Improving the Prediction of Prostate Cancer Overall Survival by Supplementing Readily Available Clinical Data with Gene Expression Levels of IGFBP3 and F3 in Formalin-Fixed Paraffin Embedded Core Needle Biopsy Material
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- 2016-01-05
- Public Library of Science (PLoS),2016
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-276821
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-276821URI
- https://doi.org/10.1371/journal.pone.0145545DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:132791933URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Background A previously reported expression signature of three genes (IGFBP3, F3 and VGLL3) was shown to have potential prognostic value in estimating overall and cancer-specific survivals at diagnosis of prostate cancer in a pilot cohort study using freshly frozen Fine Needle Aspiration (FNA) samples. Methods We carried out a new cohort study with 241 prostate cancer patients diagnosed from 20042007 with a follow-up exceeding 6 years in order to verify the prognostic value of gene expression signature in formalin fixed paraffin embedded (FFPE) prostate core needle biopsy tissue samples. The cohort consisted of four patient groups with different survival times and death causes. A four multiplex one-step RT-qPCR test kit, designed and optimized for measuring the expression signature in FFPE core needle biopsy samples, was used. In archive FFPE biopsy samples the expression differences of two genes (IGFBP3 and F3) were measured. The survival time predictions using the current clinical parameters only, such as age at diagnosis, Gleason score, PSA value and tumor stage, and clinical parameters supplemented with the expression levels of IGFBP3 and F3, were compared. Results When combined with currently used clinical parameters, the gene expression levels of IGFBP3 and F3 are improving the prediction of survival time as compared to using clinical parameters alone. Conclusion The assessment of IGFBP3 and F3 gene expression levels in FFPE prostate cancer tissue would provide an improved survival prediction for prostate cancer patients at the time of diagnosis.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
- Andersson, KarlUppsala universitet,Institutionen för immunologi, genetik och patologi,Ridgeview Instruments AB, Uppsala, Sweden. (author)
- Lindholm, JohanKarolinska Univ Hosp, Clin Pathol Cytol, Stockholm, Sweden. (author)
- Dethlefsen, OlgaKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. (author)
- Pramana, SetiaKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. (author)
- Pawitan, YudiKarolinska Institutet (author)
- Nister, MonicaKarolinska Institutet (author)
- Nilsson, StenKarolinska Institutet (author)
- Li, ChundeKarolinska Institutet (author)
- Karolinska InstitutetInstitutionen för immunologi, genetik och patologi (creator_code:org_t)
Related titles
- In:PLOS ONE: Public Library of Science (PLoS)11:11932-6203
Internet link
- https://uu.diva-portal.org/smash/get/diva2:903496/FULLTEXT01.pdffulltext:print
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0145545&type=printable
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-276821
- https://doi.org/10.1371/journal.pone.0145545
- http://kipublications.ki.se/Default.aspx?queryparsed=id:132791933
- 3 of 3
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Peng, Zhuochun
- Andersson, Karl
- Lindholm, Johan
- Dethlefsen, Olga
- Pramana, Setia
- Pawitan, Yudi
- show more...
- Nister, Monica
- Nilsson, Sten
- Li, Chunde
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cancer and Oncol ...
- Articles in the publication
- PLOS ONE
- By the university
- Uppsala University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
