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  • Georgakis, Marios K (author)

Comorbidity of Cognitive Impairment and Late-Life Depression Increase Mortality : Results From a Cohort of Community-Dwelling Elderly Individuals in Rural Greece

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-02-25
  • SAGE Publications,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-279109
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-279109URI
  • https://doi.org/10.1177/0891988716632913DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE: To investigate the association of cognitive impairment (COGI) and depression with all-cause mortality and cardiovascular-specific mortality among community-dwelling elderly individuals in rural Greece.METHODS: Cognition and depressive symptomatology of 676 Velestino town residents aged ≥60 years were assessed using Mini-Mental State Examination (MMSE) and Geriatric Depression Scale (GDS), respectively. Eight-year all-cause mortality and cardiovascular mortality were explored by multivariate Cox regression models controlling for major confounders.RESULTS: Two hundred and one patients died during follow-up. Cognitive impairment (MMSE ≤ 23) was independently associated with all-cause mortality (hazard ratio [HR]: 1.57, 95% confidence interval [CI]: 1.13-2.18) and cardiovascular mortality (HR: 1.57, 95%CI: 1.03-2.41). Moderate to severe depression (GDS > 10) was significantly associated only with a 51% increase in all-cause mortality. A male-specific association was noted for moderate to severe depression, whereas the effect of COGI was limited to females. Noteworthy, COGI and depression comorbidity, rather than their sole presence, increased all-cause mortality and cardiovascular mortality by 66% and 72%, respectively. The mortality effect of COGI was augmented among patients with depression and of depression among patients with COGI.CONCLUSION: COGI and depression, 2 entities often coexisting among elderly individuals, appear to increase all-cause mortality and cardiovascular mortality. Gender-specific modes may prevail but their comorbidity should be carefully assessed, as it seems to represent an independent index of increased frailty, which eventually shortens life expectancy.

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  • Papadopoulos, Fotios CUppsala universitet,Psykiatri, Akademiska sjukhuset(Swepub:uu)fotpa105 (author)
  • Protogerou, Athanasios D (author)
  • Pagonari, Ioanna (author)
  • Sarigianni, Fani (author)
  • Biniaris-Georgallis, Stylianos-Iason (author)
  • Kalogirou, Eleni I (author)
  • Thomopoulos, Thomas P (author)
  • Kapaki, Elisabeth (author)
  • Papageorgiou, Charalampos (author)
  • Papageorgiou, Socratis G (author)
  • Tousoulis, Dimitrios (author)
  • Petridou, Eleni Th (author)
  • Uppsala universitetPsykiatri, Akademiska sjukhuset (creator_code:org_t)

Related titles

  • In:Journal of Geriatric Psychiatry and Neurology: SAGE Publications29:4, s. 195-2040891-98871552-5708

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