Sökning: WFRF:(Baccarani M) >
Prognosis of long-t...
Prognosis of long-term survival considering disease-specific death in patients with chronic myeloid leukemia
-
- Pfirrmann, M. (författare)
- Univ Munich, Inst Med Informationsverarbeitung Biometrie & Epi, Marchioninistr 15, D-81377 Munich, Germany.
-
- Baccarani, M. (författare)
- Univ Bologna, S Orsola Malpighi Hosp, Hematol & Oncol L&A Seragnoli, Bologna, Italy.
-
- Saussele, S. (författare)
- Heidelberg Univ, Med Fak Mannheim, Univ Med Mannheim, Med Klin 3, Mannheim, Germany.
-
visa fler...
-
- Guilhot, J. (författare)
- CHU Poitiers, INSERM, CIC 1402, Clin Invest Ctr, Poitiers, France.
-
- Cervantes, F. (författare)
- Univ Barcelona, IDIBAPS, Hosp Clin, Hematol Dept, Barcelona, Spain.
-
- Ossenkoppele, G. (författare)
- Vrije Univ Amsterdam, Med Ctr, Dept Hematol, Amsterdam, Netherlands.
-
- Hoffmann, V. S. (författare)
- Univ Munich, Inst Med Informationsverarbeitung Biometrie & Epi, Marchioninistr 15, D-81377 Munich, Germany.
-
- Castagnetti, F. (författare)
- Univ Bologna, S Orsola Malpighi Hosp, Hematol & Oncol L&A Seragnoli, Bologna, Italy.
-
- Hasford, J. (författare)
- Univ Munich, Inst Med Informationsverarbeitung Biometrie & Epi, Marchioninistr 15, D-81377 Munich, Germany.
-
- Hehlmann, R. (författare)
- Heidelberg Univ, Med Fak Mannheim, Univ Med Mannheim, Med Klin 3, Mannheim, Germany.
-
- Simonsson, Bengt (författare)
- Uppsala universitet,Hematologi
-
visa färre...
-
Univ Munich, Inst Med Informationsverarbeitung Biometrie & Epi, Marchioninistr 15, D-81377 Munich, Germany Univ Bologna, S Orsola Malpighi Hosp, Hematol & Oncol L&A Seragnoli, Bologna, Italy. (creator_code:org_t)
- 2015-09-29
- 2016
- Engelska.
-
Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 30:1, s. 48-56
- Relaterad länk:
-
https://www.nature.c...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- In patients with chronic myeloid leukemia (CML), first-line imatinib treatment leads to 8-year overall survival (OS) probabilities above 80%. Many patients die of reasons unrelated to CML. This work tackled the reassessment of prognosis under particular consideration of the probabilities of dying of CML. Analyses were based on 2290 patients with chronic phase CML treated with imatinib in six clinical trials. 'Death due to CML' was defined by death after disease progression. At 8 years, OS was 89%. Of 208 deceased patients, 44% died of CML. Higher age, more peripheral blasts, bigger spleen and low platelet counts were significantly associated with increased probabilities of dying of CML and determined a new long-term survival score with three prognostic groups. Compared with the low-risk group, the patients of the intermediate-and the high-risk group had significantly higher probabilities of dying of CML. The score was successfully validated in an independent sample of 1120 patients. In both samples, the new score differentiated probabilities of dying of CML better than the Sokal, Euro and the European Treatment and Outcome Study (EUTOS) score. The new score identified 61% low-risk patients with excellent long-term outcome and 12% high-risk patients. The new score supports the prospective assessment of long-term antileukemic efficacy and risk-adapted treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Leukemia
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Pfirrmann, M.
-
Baccarani, M.
-
Saussele, S.
-
Guilhot, J.
-
Cervantes, F.
-
Ossenkoppele, G.
-
visa fler...
-
Hoffmann, V. S.
-
Castagnetti, F.
-
Hasford, J.
-
Hehlmann, R.
-
Simonsson, Bengt
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
- Artiklar i publikationen
-
Leukemia
- Av lärosätet
-
Uppsala universitet