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- Cashin, Peter H.Uppsala universitet,Kolorektalkirurgi (author)
Cytoreductive surgery and intraperitoneal chemotherapy versus systemic chemotherapy for colorectal peritoneal metastases : A randomised trial
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- Elsevier BV,2016
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-280096
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280096URI
- https://doi.org/10.1016/j.ejca.2015.09.017DOI
- https://lup.lub.lu.se/record/8592453URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:132854040URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Background: First-line treatment of isolated resectable colorectal peritoneal metastases remains unclear. This study (the Swedish peritoneal study) compares cytoreductive surgery and intraperitoneal chemotherapy (surgery arm) with systemic chemotherapy (chemotherapy arm). Methods: Patients deemed resectable preoperatively were randomised to surgery and intraperitoneal 5-fluorouracil 550 mg/m(2) /d for 6 d with repeated courses every month or to systemic oxaliplatin and 5-fluorouracil regimen every second week. Both treatments continued for 6 months. Primary end-point was overall survival (OS) and secondary end-points were progression-free survival (PFS), and morbidity. Results: The study terminated prematurely when 48 eligible patients (24/arm) were included due to recruitment difficulties. Two-year OS was 54% in the surgery arm and 38% in the chemotherapy arm (p = 0.04). After 5 years, 8 versus 1 patient were alive, respectively (p = 0.02). Median OS was 25 months versus 18 months, respectively, hazard ratio 0.51 (95% confidence interval: 0.27-0.96, p = 0.04). PFS in the surgery arm was 12 months versus 11 months in the chemotherapy arm (p = 0.16) with 17% versus 0% 5-year PFS. Grade III-IV morbidity was seen in 42% and 50% of the patients, respectively. No mortalities. Conclusions: Cytoreductive surgery with intraperitoneal chemotherapy may be superior to systemic oxaliplatin-based treatment of colorectal cancer with resectable isolated peritoneal metastases.(ClinicalTrials. gov nr: NCT01524094).
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- Cytoreductive surgery
- Intraperitoneal chemotherapy
- Colorectal cancer
- Systemic chemotherapy
- Peritoneal metastases
- Peritoneal carcinomatosis
Added entries (persons, corporate bodies, meetings, titles ...)
- Mahteme, HaileUppsala universitet,Institutionen för kirurgiska vetenskaper,Uppsala Canc Clin, Uppsala, Sweden.(Swepub:uu)hailmaht (author)
- Spang, N.Uppsala universitet,Institutionen för kirurgiska vetenskaper (author)
- Syk, IngvarLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)kir-isy (author)
- Frodin, J. E.Karolinska Institutet (author)
- Torkzad, MichaelUppsala universitet,Radiologi (author)
- Glimelius, BengtUppsala universitet,Experimentell och klinisk onkologi,Karolinska Inst, Dept Pathol & Oncol, S-17176 Stockholm, Sweden.(Swepub:uu)bengglim (author)
- Graf, WilhelmUppsala universitet,Kolorektalkirurgi(Swepub:uu)wilhgraf (author)
- Uppsala universitetKolorektalkirurgi (creator_code:org_t)
Related titles
- In:European Journal of Cancer: Elsevier BV53, s. 155-1620959-80491879-0852
Internet link
- http://www.ncbi.nlm.nih.gov/pubmed/26751236?dopt=AbstractFULLTEXT
- http://dx.doi.org/10.1016/j.ejca.2015.09.017FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280096
- https://doi.org/10.1016/j.ejca.2015.09.017
- https://lup.lub.lu.se/record/8592453
- http://kipublications.ki.se/Default.aspx?queryparsed=id:132854040
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