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Transposon mutagene...
Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model.
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Bard-Chapeau, Emilie A (author)
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Nguyen, Anh-Tuan (author)
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Rust, Alistair G (author)
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- Sayadi, Ahmed (author)
- Institute of Molecular and Cell Biology, Singapore, Singapore
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Lee, Philip (author)
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Chua, Belinda Q (author)
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New, Lee-Sun (author)
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de Jong, Johann (author)
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Ward, Jerrold M (author)
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Chin, Christopher K Y (author)
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Chew, Valerie (author)
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Toh, Han Chong (author)
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Abastado, Jean-Pierre (author)
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Benoukraf, Touati (author)
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Soong, Richie (author)
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Bard, Frederic A (author)
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Dupuy, Adam J (author)
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Johnson, Randy L (author)
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Radda, George K (author)
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Chan, Eric Chun Yong (author)
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Wessels, Lodewyk F A (author)
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Adams, David J (author)
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Jenkins, Nancy A (author)
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Copeland, Neal G (author)
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(creator_code:org_t)
- 2013-12-08
- 2014
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 46:1
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The most common risk factor for developing hepatocellular carcinoma (HCC) is chronic infection with hepatitis B virus (HBV). To better understand the evolutionary forces driving HCC, we performed a near-saturating transposon mutagenesis screen in a mouse HBV model of HCC. This screen identified 21 candidate early stage drivers and a very large number (2,860) of candidate later stage drivers that were enriched for genes that are mutated, deregulated or functioning in signaling pathways important for human HCC, with a striking 1,199 genes being linked to cellular metabolic processes. Our study provides a comprehensive overview of the genetic landscape of HCC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bard-Chapeau, Em ...
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Nguyen, Anh-Tuan
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Rust, Alistair G
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Sayadi, Ahmed
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Lee, Philip
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Chua, Belinda Q
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show more...
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New, Lee-Sun
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de Jong, Johann
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Ward, Jerrold M
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Chin, Christophe ...
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Chew, Valerie
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Toh, Han Chong
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Abastado, Jean-P ...
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Benoukraf, Touat ...
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Soong, Richie
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Bard, Frederic A
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Dupuy, Adam J
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Johnson, Randy L
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Radda, George K
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Chan, Eric Chun ...
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Wessels, Lodewyk ...
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Adams, David J
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Jenkins, Nancy A
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Copeland, Neal G
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University