GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes

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Espes, Daniel,1985-Uppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin,Science for Life Laboratory, SciLifeLab (author)

GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes

Article/chapterEnglish2021

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2021-10-11
BMJ Publishing Group Ltd,2021
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-457935
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-457935URI
https://doi.org/10.1136/bmjdrc-2021-002442DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Introduction: Experimentally, gamma-aminobutyric acid (GABA) has been found to exert immune-modulatory effects and induce beta-cell regeneration, which make it a highly interesting substance candidate for the treatment of type 1 diabetes (T1D). In many countries, including those in the European Union, GABA is considered a pharmaceutical drug. We have therefore conducted a safety and dose escalation trial with the first controlled-release formulation of GABA, Remygen (Diamyd Medical).Research design and methods: Six adult male subjects with long-standing T1D (age 24.8 +/- 1.5 years, disease duration 14.7 +/- 2.2 years) were enrolled in an 11-day dose escalation trial with a controlled-release formulation of GABA, Remygen. Pharmacokinetics, glucose control and hormonal counter-regulatory response during hypoglycemic clamps were evaluated at every dose increase (200 mg, 600 mg and 1200 mg).Results: During the trial there were no serious and only a few, transient, adverse events reported. Without treatment, the counter-regulatory hormone response to hypoglycemia was severely blunted. Intake of 600 mg GABA more than doubled the glucagon, epinephrine, growth hormone and cortisol responses to hypoglycemia.Conclusions: We find that the GABA treatment was well tolerated and established a counter-regulatory response to hypoglycemia in long-standing T1D. Further studies regarding not only the clinical potential of Remygen for beta-cell regeneration but also its potential use as hypoglycemic prophylaxis are warranted. Trail registration number and EudraCT2018-001115-73.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
diabetes mellitus
type 1
hypoglycemia
receptors
GABA-A

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Liljebäck, HannaUppsala universitet,Institutionen för medicinsk cellbiologi,Institutionen för medicinska vetenskaper(Swepub:uu)hanli106 (author)
Hill, HenrikUppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa(Swepub:uu)henhi662 (author)
Elksnis, AndrisUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)andel994 (author)
Caballero-Corbalán, JoséUppsala universitet,Transplantation och regenerativ medicin(Swepub:uu)josca151 (author)
Carlsson, Per-OlaUppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin(Swepub:uu)perocarl (author)
Uppsala universitetInstitutionen för medicinsk cellbiologi (creator_code:org_t)

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