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Knee osteoarthritis...
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Yanagisawa, AkihiroKumamoto Univ, Grad Sch Med Sci, Dept Orthopaed Surg, Chuo Ku, Kumamoto 8600811, Japan.;Kumamoto Univ, Grad Sch Med Sci, Dept Neurol, Chuo Ku, 1-1-1 Honjo, Kumamoto 8600811, Japan.
(författare)
Knee osteoarthritis associated with different kinds of amyloid deposits and the impact of aging on type of amyloid
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2015-12-24
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Informa UK Limited,2016
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-283675
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-283675URI
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https://doi.org/10.3109/13506129.2015.1115758DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Amyloidosis is a protein conformational disorder in which amyloid fibrils accumulate in the extracellular space and induce organ dysfunction. Recently, two different amyloidogenic proteins, transthyretin (TTR) and apolipoprotein A-I (Apo A-I), were identified in amyloid deposits in knee joints in patients with knee osteoarthritis (OA). However, clinicopathological differences related to those two kinds of amyloid deposits in the knee joint remain to be clarified. Here, we investigated the clinicopathological features related to these knee amyloid deposits associated with knee OA and the biochemical characteristics of the amyloid deposits. We found that all of our patients with knee OA had amyloid deposits in the knee joints, especially in the meniscus, and those deposits were primarily derived from TTR and/or Apo A-I. Some patients with knee OA, however, had unclassified amyloid deposits. One of our interesting observations concerned the different effects of aging on each type of amyloid formed. The frequency of formation of ATTR deposits clearly increased with age, but that of AApo A-I deposits decreased. Furthermore, we found that similar to 16% of patients with knee OA developed ATTR/AApo A-I double deposits in the meniscus. Amyloid deposition may therefore be a common histopathological feature associated with knee OA. Also, aging may induce ATTR formation in the knee joint in elderly patients with knee OA, whereas AApo A-I formation may be inversely correlated with age.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ueda, MitsuharuKumamoto Univ, Grad Sch Med Sci, Dept Neurol, Chuo Ku, 1-1-1 Honjo, Kumamoto 8600811, Japan.
(författare)
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Sueyoshi, TakanaoKumamoto Univ, Grad Sch Med Sci, Dept Orthopaed Surg, Chuo Ku, Kumamoto 8600811, Japan.
(författare)
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Nakamura, EiichiKumamoto Univ, Grad Sch Med Sci, Dept Orthopaed Surg, Chuo Ku, Kumamoto 8600811, Japan.
(författare)
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Tasaki, MasayoshiKumamoto Univ, Grad Sch Med Sci, Dept Neurol, Chuo Ku, 1-1-1 Honjo, Kumamoto 8600811, Japan.
(författare)
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Suenaga, GenkiKumamoto Univ, Grad Sch Med Sci, Dept Neurol, Chuo Ku, 1-1-1 Honjo, Kumamoto 8600811, Japan.
(författare)
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Motokawa, HiroakiKumamoto Univ, Grad Sch Med Sci, Dept Neurol, Chuo Ku, 1-1-1 Honjo, Kumamoto 8600811, Japan.
(författare)
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Toyoshima, RisaKumamoto Univ, Grad Sch Med Sci, Dept Neurol, Chuo Ku, 1-1-1 Honjo, Kumamoto 8600811, Japan.
(författare)
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Kinoshita, YumikoKumamoto Univ, Grad Sch Med Sci, Dept Neurol, Chuo Ku, 1-1-1 Honjo, Kumamoto 8600811, Japan.
(författare)
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Misumi, YoheiKumamoto Univ, Grad Sch Med Sci, Dept Neurol, Chuo Ku, 1-1-1 Honjo, Kumamoto 8600811, Japan.
(författare)
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Yamashita, TaroKumamoto Univ, Grad Sch Med Sci, Dept Neurol, Chuo Ku, 1-1-1 Honjo, Kumamoto 8600811, Japan.
(författare)
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Sakaguchi, MitsuruKumamoto Orthoped Hosp, Chuo Ku, Kumamoto, Japan.
(författare)
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Westermark, PerUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)perweste
(författare)
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Mizuta, HiroshiKumamoto Univ, Grad Sch Med Sci, Dept Orthopaed Surg, Chuo Ku, Kumamoto 8600811, Japan.
(författare)
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Ando, YukioKumamoto Univ, Grad Sch Med Sci, Dept Neurol, Chuo Ku, 1-1-1 Honjo, Kumamoto 8600811, Japan.
(författare)
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Kumamoto Univ, Grad Sch Med Sci, Dept Orthopaed Surg, Chuo Ku, Kumamoto 8600811, Japan.;Kumamoto Univ, Grad Sch Med Sci, Dept Neurol, Chuo Ku, 1-1-1 Honjo, Kumamoto 8600811, Japan.Kumamoto Univ, Grad Sch Med Sci, Dept Neurol, Chuo Ku, 1-1-1 Honjo, Kumamoto 8600811, Japan.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Amyloid: Informa UK Limited23:1, s. 26-321350-61291744-2818
Internetlänk
Hitta via bibliotek
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Amyloid
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Till lärosätets databas
- Av författaren/redakt...
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Yanagisawa, Akih ...
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Ueda, Mitsuharu
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Sueyoshi, Takana ...
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Nakamura, Eiichi
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Tasaki, Masayosh ...
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Suenaga, Genki
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visa fler...
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Motokawa, Hiroak ...
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Toyoshima, Risa
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Kinoshita, Yumik ...
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Misumi, Yohei
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Yamashita, Taro
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Sakaguchi, Mitsu ...
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Westermark, Per
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Mizuta, Hiroshi
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Ando, Yukio
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
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och Medicinsk biotek ...
- Artiklar i publikationen
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Amyloid
- Av lärosätet
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Uppsala universitet