Altered Plasma Levels of Glucagon, GLP-1 and Glicentin During OGTT in Adolescents With Obesity and Type 2 Diabetes

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Manell, HannesUppsala universitet,Institutionen för medicinsk cellbiologi (author)

Altered Plasma Levels of Glucagon, GLP-1 and Glicentin During OGTT in Adolescents With Obesity and Type 2 Diabetes

Article/chapterEnglish2016

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The Endocrine Society,2016
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LIBRIS-ID:oai:DiVA.org:uu-292749
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-292749URI
https://doi.org/10.1210/jc.2015-3885DOI

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Language:English
Summary in:English

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CONTEXT: Proglucagon-derived hormones are important for glucose metabolism, but little is known about them in pediatric obesity and type 2 diabetes mellitus (T2DM).OBJECTIVE: Fasting and postprandial levels of proglucagon-derived peptides glucagon, GLP-1, and glicentin in adolescents with obesity across the glucose tolerance spectrum were investigated.DESIGN: This was a cross-sectional study with plasma hormone levels quantified at fasting and during an oral glucose tolerance test (OGTT).SETTING: This study took place in a pediatric obesity clinic at Uppsala University Hospital, Sweden.PATIENTS AND PARTICIPANTS: Adolescents with obesity, age 10-18 years, with normal glucose tolerance (NGT, n = 23), impaired glucose tolerance (IGT, n = 19), or T2DM (n = 4) and age-matched lean adolescents (n = 19) were included.MAIN OUTCOME MEASURES: Outcome measures were fasting and OGTT plasma levels of insulin, glucagon, active GLP-1, and glicentin.RESULTS: Adolescents with obesity and IGT had lower fasting GLP-1 and glicentin levels than those with NGT (0.25 vs 0.53 pM, P < .05; 18.2 vs 23.6 pM, P < .01) and adolescents with obesity and T2DM had higher fasting glucagon levels (18.1 vs 10.1 pM, P < .01) than those with NGT. During OGTT, glicentin/glucagon ratios were lower in adolescents with obesity and NGT than in lean adolescents (P < .01) and even lower in IGT (P < .05) and T2DM (P < .001).CONCLUSIONS: Obese adolescents with IGT have lowered fasting GLP-1 and glicentin levels. In T2DM, fasting glucagon levels are elevated, whereas GLP-1 and glicentin levels are maintained low. During OGTT, adolescents with obesity have more products of pancreatically than intestinally cleaved proglucagon (ie, more glucagon and less GLP-1) in the plasma. This shift becomes more pronounced when glucose tolerance deteriorates.

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Staaf, JohanUppsala universitet,Pediatrik,Institutionen för medicinsk cellbiologi(Swepub:uu)johst547 (author)
Manukyan, LevonUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)levma108 (author)
Kristinsson, HjaltiUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)hjakr151 (author)
Cen, JingUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)jince383 (author)
Stenlid, RasmusUppsala universitet,Institutionen för medicinsk cellbiologi (author)
Ciba, IrisUppsala universitet,Institutionen för medicinsk cellbiologi,Pediatrik(Swepub:uu)irici655 (author)
Forslund, AndersUppsala universitet,Institutionen för medicinsk cellbiologi,Pediatrik(Swepub:uu)andeforsl (author)
Bergsten, PeterUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)peteberg (author)
Uppsala universitetInstitutionen för medicinsk cellbiologi (creator_code:org_t)

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In:Journal of Clinical Endocrinology and Metabolism: The Endocrine Society101:3, s. 1181-11890021-972X1945-7197

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By the author/editor: Manell, Hannes; Staaf, Johan; Manukyan, Levon; Kristinsson, Hja ...; Cen, Jing; Stenlid, Rasmus; show more...; Ciba, Iris; Forslund, Anders; Bergsten, Peter; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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