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- Ärnlöv, Johan,1970-Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap (author)
Left Ventricular Function in Elderly Men : Metabolic, Hormonal, Genetic and Prognostic Implications
- BookEnglish2002
Publisher, publication year, extent ...
- Uppsala :Tryck och medier,2002
- 57 s.
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-2937
- ISBN:9155454585
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2937URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Series
- Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine,0282-7476 ;1204
Notes
- Heart failure and left ventricular dysfunction are major causes of morbidity and mortality. In this thesis, metabolic, hormonal, genetic and prognostic aspects of echocardiographically determined left ventricular function were investigated in a fairly large longitudinal population-based study of men. The participants were examined both at age 50 and 70 years and were followed for mortality using the national cause-of-death registry.Several factors associated with the insulin resistance syndrome predicted left ventricular systolic dysfunction independent of myocardial infarction, hypertension, diabetes and the use of cardiovascular medication after twenty years follow-up. Plasma levels of N-terminal atrial natriuretic peptide (N-ANP) were significantly increased in men with left ventricular dysfunction in comparison to healthy men. However, the diagnostic accuracy was poor due to the extensive overlapping between the groups. Relations between a haplotype of the novel hUNC-93B1 gene and the E/A-ratio were found and validated in separate samples of the cohort. Myocardial performance index (a Doppler derived index of combined left ventricular systolic and diastolic function) and left ventricular ejection fraction were found to be predictors for cardiovascular mortality independent of traditional cardiovascular risk factors in a longitudinal analysis with a mean follow-up of seven years.In conclusion, this thesis showed that left ventricular function is influenced by metabolic, hormonal and genetic factors and that echocardiographic measurements of left ventricular function, such as the myocardial performance index, are strong independent risk factors for cardiovascular mortality in elderly men.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
- Medicine
- echocardiography
- heart failure
- left ventricular function
- genetics
- mortality
- insulin sensitivity
- natriuretic peptides
- Medicin
- Dermatology and venerology,clinical genetics, internal medicine
- Dermatologi och venerologi, klinisk genetik, invärtesmedicin
- Geriatrics
- geriatrik
Added entries (persons, corporate bodies, meetings, titles ...)
- Waldenström, Anders (opponent)
- Uppsala universitetInstitutionen för folkhälso- och vårdvetenskap (creator_code:org_t)
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