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- Pettersson, MatsSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences (author)
Capacitating epistasis--detection and role in the genetic architecture of complex traits.
- Article/chapterEnglish2015
Publisher, publication year, extent ...
- 2014-11-03
- New York, NY :Springer New York,2015
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-294200
- ISBN:9781493921546
- ISBN:9781493921553
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-294200URI
- https://doi.org/10.1007/978-1-4939-2155-3_10DOI
- https://res.slu.se/id/publ/83558URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Here, we discuss the potential role of capacitating epistasis in the genetic architecture of complex traits. Two alternative methods for identifying such gene-gene interactions in genetic association studies-mapping of variance controlling loci and the variance plane ratio (VPR) method-are introduced. An overview of the theoretical foundation of the methods is presented together with a discussion on their implementation and available software for performing these analyses. We conclude by highlighting a few examples of capacitating epistasis described in the literature and its potential impacts on the genetics of complex traits.
Subject headings and genre
- NATURVETENSKAP Biologi Genetik hsv//swe
- NATURAL SCIENCES Biological Sciences Genetics hsv//eng
- Bioinformatik
- Bioinformatics
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- Carlborg, ÖrjanSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences(Swepub:slu)48083 (author)
- Sveriges lantbruksuniversitetInstitutionen för kliniska vetenskaper (KV) (creator_code:org_t)
- Sveriges lantbruksuniversitet
Related titles
- In:Methods in Molecular BiologyNew York, NY : Springer New York1253:1253, s. 185-1961064-37451940-6029
- In:Epistasis : methods and protocolsNew York, NY : Springer New York1253:1253, s. 185-1969781493921546
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