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  • Majeed, AmmarKarolinska Institutet (författare)

Effectiveness and outcome of management strategies for dabigatran- or warfarin-related major bleeding events

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-295563
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-295563URI
  • https://doi.org/10.1016/j.thromres.2016.02.005DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:133329711URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Strategies used for the management of dabigatran-related major bleeding events (MBEs), and their effectiveness have not been systematically evaluated.Methods: Reports on 1034 individuals experiencing 1121 MBEs (696 on dabigatran, and 425 on warfarin) in 5 phase III randomized controlled trials were assessed independently by two investigators.Results: MBEs were managed either by drug discontinuation only (37%), or drug discontinuation with either transfusion of only red cell concentrates (38%), or plasma (23%). Few MBEs (2%) were treated with coagulation factor concentrates. The effectiveness of the management was assessed as good in significantly larger proportion of MBEs on dabigatran (91%) than on warfarin (84%, odds ratio [OR] 1.68; 95% confidence interval [CI], 1.14-2.49), which was consistent with the lower 30-day mortality (OR (OR 0.66; 95% CI, 0.44-1.00)). The effectiveness of bleeding management in non-traumatic bleeding was better in patients with dabigatran than with warfarin (OR 1.82; 95% CI, 1.18-2.79) but was similar in traumatic bleeding (OR 0.75; 95% CI, 0.25-2.30). The relative effectiveness of management of bleeding and 30-day mortality rates across other key subgroups of patients or sites of bleeding, the use of platelet inhibitors, age-, sex-and renal function subgroups, were comparable in MBEs on dabigatran or warfarin.Conclusion: Despite the unavailability of a specific antidote at the time of these studies, bleeding in patients receiving dabigatran was managed in the overwhelming majority of patients without coagulation factor concentrates, with comparable or superior effectiveness and lower 30-day mortality rates versus those who bleed while receiving warfarin.

Ämnesord och genrebeteckningar

  • Coumarins
  • Dabigatran etexilate
  • Bleeding
  • Management

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hwang, Hun-GyuSoonchunhyang Univ, Gumis Hosp, Dept Med, Asan, North Kyungsang, South Korea. (författare)
  • Eikelboom, John W.Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Hamilton, ON, Canada. (författare)
  • Connolly, StuartHamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Hamilton, ON, Canada. (författare)
  • Wallentin, LarsUppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)larswall (författare)
  • Feuring, MartinBoehringer Ingelheim Pharma GmbH & Co KG, Ingelheim, Germany. (författare)
  • Brueckmann, MartinaBoehringer Ingelheim Pharma GmbH & Co KG, Ingelheim, Germany.;Heidelberg Univ, Fac Med Mannheim, Mannheim, Germany. (författare)
  • Noack, Herbert (författare)
  • Yusuf, SalimHamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Hamilton, ON, Canada. (författare)
  • Schulman, SamKarolinska Univ Hosp, Hematol Ctr, Coagulat Unit, D1 02, SE-17176 Stockholm, Sweden.;Karolinska Inst, Stockholm, Sweden.;Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada.;Thrombosis & Atherosclerosis Res Inst, Hamilton, ON, Canada. (författare)
  • Karolinska InstitutetSoonchunhyang Univ, Gumis Hosp, Dept Med, Asan, North Kyungsang, South Korea. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Thrombosis Research: Elsevier BV140, s. 81-880049-38481879-2472

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