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Electron tomography...
Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits
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- Kollmer, Marius (author)
- Univ Ulm, Inst Prot Biochem, D-89081 Ulm, Germany.
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- Meinhardt, Katrin (author)
- Univ Ulm, Inst Prot Biochem, D-89081 Ulm, Germany.
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- Haupt, Christian (author)
- Univ Ulm, Inst Prot Biochem, D-89081 Ulm, Germany.
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- Liberta, Falk (author)
- Univ Ulm, Inst Prot Biochem, D-89081 Ulm, Germany.
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- Wulff, Melanie (author)
- Univ Ulm, Inst Prot Biochem, D-89081 Ulm, Germany.
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- Linder, Julia (author)
- Univ Ulm, Inst Prot Biochem, D-89081 Ulm, Germany.
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- Handl, Lisa (author)
- Univ Ulm, Inst Stochast, D-89081 Ulm, Germany.
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- Heinrich, Liesa (author)
- Hans Knoell Inst, Leibniz Inst Nat Prod Res & Infect Biol, D-07745 Jena, Germany.
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- Loos, Cornelia (author)
- Univ Ulm, Inst Prot Biochem, D-89081 Ulm, Germany.
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- Schmidt, Matthias (author)
- Univ Ulm, Inst Prot Biochem, D-89081 Ulm, Germany.
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- Syrovets, Tatiana (author)
- Univ Ulm, Inst Pharmacol Nat Prod & Clin Pharmacol, D-89081 Ulm, Germany.
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- Simmet, Thomas (author)
- Univ Ulm, Inst Pharmacol Nat Prod & Clin Pharmacol, D-89081 Ulm, Germany.
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- Westermark, Per (author)
- Uppsala universitet,Klinisk och experimentell patologi,Per Westermark
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- Westermark, Gunilla T. (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Horn, Uwe (author)
- Hans Knoell Inst, Leibniz Inst Nat Prod Res & Infect Biol, D-07745 Jena, Germany.
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- Schmidt, Volker (author)
- Univ Ulm, Inst Stochast, D-89081 Ulm, Germany.
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- Walther, Paul (author)
- Univ Ulm, Cent Electron Microscopy Facil, D-89081 Ulm, Germany.
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- Faendrich, Marcus (author)
- Univ Ulm, Inst Prot Biochem, D-89081 Ulm, Germany.
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Univ Ulm, Inst Prot Biochem, D-89081 Ulm, Germany Univ Ulm, Inst Stochast, D-89081 Ulm, Germany. (creator_code:org_t)
- 2016-05-02
- 2016
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 113:20, s. 5604-5609
- Related links:
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https://www.pnas.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Electron tomography is an increasingly powerful method to study the detailed architecture of macromolecular complexes or cellular structures. Applied to amyloid deposits formed in a cell culture model of systemic amyloid A amyloidosis, we could determine the structural morphology of the fibrils directly in the deposit. The deposited fibrils are arranged in different networks, and depending on the relative fibril orientation, we can distinguish between fibril meshworks, fibril bundles, and amyloid stars. These networks are frequently infiltrated by vesicular lipid inclusions that may originate from the death of the amyloid-forming cells. Our data support the role of nonfibril components for constructing fibril deposits and provide structural views of different types of lipid-fibril interactions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- aggregation
- conformational disease
- electron tomography
- protein assembly
- prion
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kollmer, Marius
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Meinhardt, Katri ...
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Haupt, Christian
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Liberta, Falk
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Wulff, Melanie
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Linder, Julia
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show more...
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Handl, Lisa
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Heinrich, Liesa
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Loos, Cornelia
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Schmidt, Matthia ...
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Syrovets, Tatian ...
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Simmet, Thomas
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Westermark, Per
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Westermark, Guni ...
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Horn, Uwe
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Schmidt, Volker
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Walther, Paul
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Faendrich, Marcu ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
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Uppsala University