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  • Lai, ZhennanUppsala universitet,Institutionen för farmaceutisk biovetenskap,Natl Inst Dent & Craniofacial Res, Adenoassociated Virus Biol Sect, Mol Physiol & Therapeut Branch, NIH, Bethesda, MD 20892 USA. (author)

Aquaporin gene therapy corrects Sjogren's syndrome phenotype in mice

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-05-02
  • Proceedings of the National Academy of Sciences,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-297780
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-297780URI
  • https://doi.org/10.1073/pnas.1601992113DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Primary Sjogren's syndrome (pSS) is a chronic autoimmune disease that is estimated to affect 35 million people worldwide. Currently, no effective treatments exist for Sjogren's syndrome, and there is a limited understanding of the physiological mechanisms associated with xerostomia and hyposalivation. The present work revealed that aquaporin 5 expression, a water channel critical for salivary gland fluid secretion, is regulated by bone morphogenetic protein 6. Increased expression of this cytokine is strongly associated with the most common symptom of primary Sjogren's syndrome, the loss of salivary gland function. This finding led us to develop a therapy in the treatment of Sjogren's syndrome by increasing the water permeability of the gland to restore saliva flow. Our study demonstrates that the targeted increase of gland permeability not only resulted in the restoration of secretory gland function but also resolved the hallmark salivary gland inflammation and systemic inflammation associated with disease. Secretory function also increased in the lacrimal gland, suggesting this local therapy could treat the systemic symptoms associated with primary Sjogren's syndrome.

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  • Yin, HongenNatl Inst Dent & Craniofacial Res, Adenoassociated Virus Biol Sect, Mol Physiol & Therapeut Branch, NIH, Bethesda, MD 20892 USA. (author)
  • Cabrera-Perez, JavierNatl Inst Dent & Craniofacial Res, Adenoassociated Virus Biol Sect, Mol Physiol & Therapeut Branch, NIH, Bethesda, MD 20892 USA. (author)
  • Guimaro, Maria C.Natl Inst Dent & Craniofacial Res, Adenoassociated Virus Biol Sect, Mol Physiol & Therapeut Branch, NIH, Bethesda, MD 20892 USA. (author)
  • Afione, SandraNatl Inst Dent & Craniofacial Res, Adenoassociated Virus Biol Sect, Mol Physiol & Therapeut Branch, NIH, Bethesda, MD 20892 USA. (author)
  • Michael, Drew G.Natl Inst Dent & Craniofacial Res, Adenoassociated Virus Biol Sect, Mol Physiol & Therapeut Branch, NIH, Bethesda, MD 20892 USA. (author)
  • Glenton, PatriciaUniv Florida, Dept Pathol & Infect Dis, Gainesville, FL 32611 USA. (author)
  • Patel, AnkurNatl Inst Dent & Craniofacial Res, Adenoassociated Virus Biol Sect, Mol Physiol & Therapeut Branch, NIH, Bethesda, MD 20892 USA. (author)
  • Swaim, William D.Natl Inst Dent & Craniofacial Res, Adenoassociated Virus Biol Sect, Mol Physiol & Therapeut Branch, NIH, Bethesda, MD 20892 USA. (author)
  • Zheng, ChangyuNatl Inst Dent & Craniofacial Res, Adenoassociated Virus Biol Sect, Mol Physiol & Therapeut Branch, NIH, Bethesda, MD 20892 USA. (author)
  • Nguyen, Cuong Q.Univ Florida, Dept Pathol & Infect Dis, Gainesville, FL 32611 USA. (author)
  • Nyberg, FredUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)frednybe (author)
  • Chiorini, John A.Natl Inst Dent & Craniofacial Res, Adenoassociated Virus Biol Sect, Mol Physiol & Therapeut Branch, NIH, Bethesda, MD 20892 USA. (author)
  • Uppsala universitetInstitutionen för farmaceutisk biovetenskap (creator_code:org_t)

Related titles

  • In:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences113:20, s. 5694-56990027-84241091-6490

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