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Interferons Induce ...
Interferons Induce STAT1-Dependent Expression of Tissue Plasminogen Activator, a Pathogenicity Factor in Puumala Hantavirus Disease
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- Strandin, Tomas (författare)
- Univ Helsinki, Fac Med, Dept Virol, POB 21,Haartmaninkatu 3, FI-00014 Helsinki, Finland.
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- Hepojoki, Jussi (författare)
- Univ Helsinki, Fac Med, Dept Virol, POB 21,Haartmaninkatu 3, FI-00014 Helsinki, Finland.
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- Laine, Outi (författare)
- Univ Tampere, Sch Med, FIN-33101 Tampere, Finland.;Tampere Univ Hosp, Dept Internal Med, Tampere, Finland.
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- Mäkelä, Satu (författare)
- Univ Tampere, Sch Med, FIN-33101 Tampere, Finland.;Tampere Univ Hosp, Dept Internal Med, Tampere, Finland.
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- Klingström, Jonas (författare)
- Karolinska Institutet
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- Lundkvist, Åke (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Julkunen, Ilkka (författare)
- Natl Inst Hlth & Welf, Dept Infect Dis Surveillance & Control, Helsinki, Finland.;Univ Turku, Dept Virol, SF-20500 Turku, Finland.
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- Mustonen, Jukka (författare)
- Univ Tampere, Sch Med, FIN-33101 Tampere, Finland.;Tampere Univ Hosp, Dept Internal Med, Tampere, Finland.
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- Vaheri, Antti (författare)
- Univ Helsinki, Fac Med, Dept Virol, POB 21,Haartmaninkatu 3, FI-00014 Helsinki, Finland.
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Univ Helsinki, Fac Med, Dept Virol, POB 21,Haartmaninkatu 3, FI-00014 Helsinki, Finland Univ Tampere, Sch Med, FIN-33101 Tampere, Finland.;Tampere Univ Hosp, Dept Internal Med, Tampere, Finland. (creator_code:org_t)
- 2015-12-23
- 2016
- Engelska.
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Ingår i: Journal of Infectious Diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 213:10, s. 1632-1641
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Hantaviruses are zoonotic viruses that show various degrees of vasculopathy in humans. In this study, we analyzed the regulation of 2 fibrinolytic parameters, tissue plasminogen activator (tPA) and its physiological inhibitor, plasminogen activator inhibitor 1 (PAI-1), in Puumala hantavirus (PUUV)-infected patients and in human microvascular endothelial cells. We detected strong upregulation of tPA in the acute phase of illness and in PUUV-infected macaques and found the tPA level to positively correlate with disease severity. The median levels of PAI-1 during the acute stage did not differ from those during the recovery phase. In concordance, hantaviruses induced tPA but not PAI-1 in microvascular endothelial cells, and the induction was demonstrated to be dependent on type I interferon. Importantly, type I and II interferons directly upregulated tPA through signal transducer and activator of transcription 1 (STAT1), which regulated tPA gene expression via a STAT1-responsive enhancer element. These results suggest that tPA may be a general factor in the immunological response to viruses.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- tissue plasminogen activator
- interferon
- STAT1
- hantavirus
- hemorrhagic fever
- innate immunity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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