Search: id:"swepub:oai:DiVA.org:uu-298778" >
Enhanced growth of ...
-
Melki, Vilyam,1972-Uppsala universitet,Institutionen för kirurgiska vetenskaper
(author)
Enhanced growth of Staphylococcus aureus after nitric oxide supplementation during simulated extracorporeal circulation
- Article/chapterEnglish2010
Publisher, publication year, extent ...
-
2010-03-23
-
Georg Thieme Verlag KG,2010
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-298778
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-298778URI
-
https://doi.org/10.1055/s-0029-1186135DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Background: Several factors contribute to postoperative bacterial infections in cardiac surgery. Long operation times and the use of extracorporeal circulation increase the risk of infection. Nitric oxide has been shown to possess a broad spectrum antimicrobial effect. Methods: In this study, we investigated the effect of nitric oxide on S. aureus growth in whole blood during simulated extracorporeal circulation. Results: S. aureus growth increased 6.2-fold after 180 min SECC in the presence of nitric oxide. Leukocyte counts remained unchanged without any differences between the groups. We observed a steady increase in markers of oxidative stress and activity of the innate immune system. Myeloperoxidase levels increased 8-fold, and C3a and terminal complement complex by 2-fold after 180 min. Conclusion: S. aureus growth is not due to the effect of nitric oxide on the innate immune system but from its effect on the bacteria itself. It has been shown that nitric oxide stimulates the expression of inducible lactate dehydrogenase, specific to S. aureus, which improves its resistance to oxidative stress, and may give S. aureus a survival advantage resulting in increased growth.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Tran, P.K.Uppsala universitet,Institutionen för kirurgiska vetenskaper
(author)
-
Tano, EvaUppsala universitet,Klinisk mikrobiologi och infektionsmedicin(Swepub:uu)evata102
(author)
-
Knutson, FolkeUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)folkknut
(author)
-
Borowiec, Jan W.Uppsala universitet,Thoraxkirurgi(Swepub:uu)janborow
(author)
-
Uppsala universitetInstitutionen för kirurgiska vetenskaper
(creator_code:org_t)
Related titles
-
In:The thoracic and cardiovascular surgeon: Georg Thieme Verlag KG58:2, s. 81-850171-64251439-1902
Internet link
Find in a library
To the university's database