Suboptimal Control of Lipid Levels: Results from 29 Countries Participating in the Centralized Pan-Regional Surveys on the Undertreatment of Hypercholesterolaemia (CEPHEUS)

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Chiang, Chern-EnTaipei Vet Gen Hosp, Div Cardiol, Gen Clin Res Ctr, Taipei, Taiwan.;Natl Yang Ming Univ, Taipei 112, Taiwan. (author)

Suboptimal Control of Lipid Levels : Results from 29 Countries Participating in the Centralized Pan-Regional Surveys on the Undertreatment of Hypercholesterolaemia (CEPHEUS)

Article/chapterEnglish2016

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Japan Atherosclerosis Society,2016
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LIBRIS-ID:oai:DiVA.org:uu-298929
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-298929URI
https://doi.org/10.5551/jat.31179DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Aim: Five multicentre, cross-sectional Centralized Pan-Regional Surveys on the Undertreatment of Hypercholesterolaemia (CEPHEUS) were conducted in 29 countries across Asia, Western Europe, Eastern Europe, the Middle East, and Africa. The surveys assessed the current use and efficacy of lipid-lowering drugs (LLDs) worldwide and identified possible patient and physician characteristics associated with failure to attain low-density lipoprotein cholesterol (LDL-C) goals. The aim of this analysis was to consolidate the global results from these surveys. Methods: The surveys involved patients aged >= 18 years who had been prescribed LLDs for at least 3 months without dose changes for at least 6 weeks. A single visit was scheduled for data collection, including fasting plasma lipid and glucose levels. Cardiovascular risk profile and LDL-C goal attainment were assessed according to the 2004 updated US National Cholesterol Education Program Adult Treatment Panel III guidelines. Results: In total, 35 121 patients (mean age: 60.4 years) were included, and 90.3% had been prescribed statin monotherapy. Overall, only 49.4% of patients reached their recommended LDL-C level. LDL-C goals were attained in 54.8% (5084/9273) and 22.8% (3287/14 429) of patients were at high and very high cardiovascular risk, respectively. Factors associated with an increased likelihood of LDL-C goal attainment were lower baseline cardiovascular risk; presence of diabetes mellitus, hypertension, or history of cardiovascular disease; and treatment with simvastatin, atorvastatin, or rosuvastatin (vs. all other LLDs). Conclusion: LDL-C goal attainment in patients taking LLDs is suboptimal worldwide, particularly in patients at high and very high cardiovascular risk.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Cardiovascular disease
Hypercholesterolaemia
Lipidlowering drugs
Low-density lipoprotein cholesterol
Undertreatment

Added entries (persons, corporate bodies, meetings, titles ...)

Ferrieres, JeanToulouse Univ Hosp, Dept Cardiol, Toulouse, France. (author)
Gotcheva, Nina N.Natl Heart Hosp, Dept Cardiol, Sofia, Bulgaria. (author)
Raal, Frederick J.Johannesburg Hosp, Fac Hlth Sci, Johannesburg, South Africa. (author)
Shehab, AbdullaUnited Arab Emirates Univ, Dept Internal Med, Al Ain, U Arab Emirates. (author)
Sung, JidongSungkyunkwan Univ, Sch Med, Samsung Med Ctr, Seoul, South Korea. (author)
Henriksson, Karin M.Uppsala universitet,Kardiovaskulär epidemiologi,AstraZeneca Gothenburg, Mölndal, Sweden.(Swepub:uu)karhe322 (author)
Hermans, Michel P.Clin Univ St Luc, Endocrinol & Nutr, B-1200 Brussels, Belgium. (author)
Taipei Vet Gen Hosp, Div Cardiol, Gen Clin Res Ctr, Taipei, Taiwan.;Natl Yang Ming Univ, Taipei 112, Taiwan.Toulouse Univ Hosp, Dept Cardiol, Toulouse, France. (creator_code:org_t)

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In:Journal of Atherosclerosis and Thrombosis: Japan Atherosclerosis Society23:5, s. 567-5871880-38731340-3478

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