Sökning: WFRF:(Chen Longyun) >
Genetic heterogenei...
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Wu, ChenglinKarolinska Inst, Karolinska Univ Hosp, Div Clin Immunol & Transfus Med, Stockholm, Sweden.
(författare)
Genetic heterogeneity in primary and relapsed mantle cell lymphomas : Impact of recurrent CARD11 mutations
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2016-05-20
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Impact Journals, LLC,2016
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-299715
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-299715URI
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https://doi.org/10.18632/oncotarget.9500DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:133795262URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The genetic mechanisms underlying disease progression, relapse and therapy resistance in mantle cell lymphoma (MCL) remain largely unknown. Whole-exome sequencing was performed in 27 MCL samples from 13 patients, representing the largest analyzed series of consecutive biopsies obtained at diagnosis and/or relapse for this type of lymphoma. Eighteen genes were found to be recurrently mutated in these samples, including known (ATM, MEF2B and MLL2) and novel mutation targets (S1PR1 and CARD11). CARD11, a scaffold protein required for B-cell receptor (BCR)-induced NF-kappa B activation, was subsequently screened in an additional 173 MCL samples and mutations were observed in 5.5% of cases. Based on in vitro cell line-based experiments, overexpression of CARD11 mutants were demonstrated to confer resistance to the BCR-inhibitor ibrutinib and NF-kappa B-inhibitor lenalidomide. Genetic alterations acquired in the relapse samples were found to be largely non-recurrent, in line with the branched evolutionary pattern of clonal evolution observed in most cases. In summary, this study highlights the genetic heterogeneity in MCL, in particular at relapse, and provides for the first time genetic evidence of BCR/NF-kappa B activation in a subset of MCL.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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de Miranda, Noel F. C. C.Karolinska Inst, Karolinska Univ Hosp, Div Clin Immunol & Transfus Med, Stockholm, Sweden.
(författare)
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Chen, LongyunKarolinska Inst, Karolinska Univ Hosp, Div Clin Immunol & Transfus Med, Stockholm, Sweden.;Beijing Genom Inst, Shenzhen, Peoples R China.
(författare)
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Wasik, Agata M.Karolinska Institutet,Karolinska Inst, Dept Lab Med, Div Pathol, Karolinska Univ Hosp, Stockholm, Sweden.,Jagiellonian Univ, Fac Hlth Sci, Coll Med, Krakow, Poland.
(författare)
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Mansouri, LarryUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)maman377
(författare)
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Jurczak, WojciechJagiellonian Univ, Dept Hematol, Coll Med, Krakow, Poland.
(författare)
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Galazka, KrystynaJagiellonian Univ, Dept Pathol, Coll Med, Krakow, Poland.
(författare)
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Dlugosz-Danecka, MonikaJagiellonian Univ, Dept Hematol, Coll Med, Krakow, Poland.
(författare)
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Machaczka, MaciejJagiellonian Univ, Fac Hlth Sci, Coll Med, Krakow, Poland.
(författare)
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Zhang, HuilaiTianjin Med Univ, Dept Lymphoma, Canc Hosp & Inst, Tianjin, Peoples R China.
(författare)
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Peng, RoujunSun Yat Sen Univ, Dept Med Oncol, Collaborat Innovat Ctr Canc Med, Canc Ctr,State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.
(författare)
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Morin, Ryan D.Simon Fraser Univ, Dept Mol Biol & Biochem, Burnaby, BC V5A 1S6, Canada.
(författare)
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Rosenquist, RichardUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)richrose
(författare)
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Sander, BirgittaKarolinska Institutet,Karolinska Inst, Dept Lab Med, Div Pathol, Karolinska Univ Hosp, Stockholm, Sweden.
(författare)
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Pan-Hammarstrom, QiangKarolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Div Clin Immunol & Transfus Med, Stockholm, Sweden.
(författare)
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Karolinska Inst, Karolinska Univ Hosp, Div Clin Immunol & Transfus Med, Stockholm, Sweden.Karolinska Inst, Karolinska Univ Hosp, Div Clin Immunol & Transfus Med, Stockholm, Sweden.;Beijing Genom Inst, Shenzhen, Peoples R China.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Oncotarget: Impact Journals, LLC7:25, s. 38180-381901949-2553
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Wu, Chenglin
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de Miranda, Noel ...
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Chen, Longyun
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Wasik, Agata M.
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Mansouri, Larry
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Jurczak, Wojciec ...
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Galazka, Krystyn ...
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Dlugosz-Danecka, ...
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Machaczka, Macie ...
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Zhang, Huilai
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Peng, Roujun
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Morin, Ryan D.
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Rosenquist, Rich ...
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Sander, Birgitta
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