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  • Georgiou, KonstantinosKarolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden. (author)

Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • American Society of Hematology,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-299719
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-299719URI
  • https://doi.org/10.1182/blood-2015-12-686550DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:133775050URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Diffuse large B-cell lymphoma (DLBCL) is one of the most common and aggressive types of B-cell lymphoma. Deregulation of proto-oncogene expression after a translocation, most notably to the immunoglobulin heavy-chain locus (IGH), is one of the hallmarks of DLBCL. Using whole-genome sequencing analysis, we have identified the PD-L1/PD-L2 locus as a recurrent translocation partner for IGH in DLBCL. PIM1 and TP63 were also identified as novel translocation partners for PD-L1/PD-L2. Fluorescence in situ hybridization was furthermore used to rapidly screen an expanded DLBCL cohort. Collectively, a subset of samples was found to be affected by gains (12%), amplifications (3%), and translocations (4%) of the PD-L1/PD-L2 locus. RNA sequencing data coupled with immunohistochemistry revealed that these cytogenetic alterations correlated with increased expression of PD-L1 but not of PD-L2. Moreover, cytogenetic alterations affecting the PD-L1/PD-L2 locus were more frequently observed in the non-germinal center B cell-like (non-GCB) subtype of DLBCL. These findings demonstrate the genetic basis of PD-L1 overexpression in DLBCL and suggest that treatments targeting the PD-1-PD-L1/PD-L2 axis might benefit DLBCL patients, especially those belonging to the more aggressive non-GCB subtype.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Chen, LongyunKarolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.;BGI Shenzhen, Shenzhen, Peoples R China. (author)
  • Berglund, MattiasKarolinska Institutet (author)
  • Ren, WeichengKarolinska Institutet (author)
  • de Miranda, Noel F. C. C.Leiden Univ, Dept Pathol, Med Ctr, Leiden, Netherlands. (author)
  • Lisboa, SusanaUniv Porto, Portuguese Oncol Inst, Dept Genet, Rua Campo Alegre 823, P-4100 Oporto, Portugal.;Univ Porto, Abel Salazar Biomed Sci Inst, Rua Campo Alegre 823, P-4100 Oporto, Portugal. (author)
  • Fangazio, MarcoColumbia Univ, Inst Canc Genet, New York, NY USA. (author)
  • Zhu, ShidaBGI Shenzhen, Shenzhen, Peoples R China. (author)
  • Hou, YongBGI Shenzhen, Shenzhen, Peoples R China. (author)
  • Wu, KuiBGI Shenzhen, Shenzhen, Peoples R China. (author)
  • Fang, WenfengSun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China. (author)
  • Wang, XianhuoTianjin Med Univ Canc Inst & Hosp, Dept Lymphoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China. (author)
  • Meng, BinTianjin Med Univ Canc Inst & Hosp, Dept Lymphoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China. (author)
  • Zhang, LiSun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China. (author)
  • Zeng, YixinSun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China. (author)
  • Bhagat, GovindColumbia Univ, Dept Pathol & Cell Biol, New York, NY USA. (author)
  • Nordenskjold, MagnusKarolinska Institutet (author)
  • Sundström, ChristerUppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini(Swepub:uu)chrisund (author)
  • Enblad, GunillaUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)gunienbl (author)
  • Dalla-Favera, RiccardoColumbia Univ, Inst Canc Genet, New York, NY USA. (author)
  • Zhang, HuilaiTianjin Med Univ Canc Inst & Hosp, Dept Lymphoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China. (author)
  • Teixeira, Manuel R.Univ Porto, Portuguese Oncol Inst, Dept Genet, Rua Campo Alegre 823, P-4100 Oporto, Portugal.;Univ Porto, Abel Salazar Biomed Sci Inst, Rua Campo Alegre 823, P-4100 Oporto, Portugal. (author)
  • Pasqualucci, LauraColumbia Univ, Inst Canc Genet, New York, NY USA. (author)
  • Peng, RoujunSun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China. (author)
  • Pan-Hammarstrom, QiangKarolinska Institutet (author)
  • Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.;BGI Shenzhen, Shenzhen, Peoples R China. (creator_code:org_t)

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  • In:Blood: American Society of Hematology127:24, s. 3026-30340006-49711528-0020

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