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Pancreatic islet bl...
Pancreatic islet blood flow and its measurement
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- Jansson, Leif (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Barbu, Andreea (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Klinisk immunologi
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- Bodin, Birgitta (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Drott, Carl Johan (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Espes, Daniel (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Gao, Xiang (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Grapensparr, Liza (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Kallskog, Örjan (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Lau, Joey Börjesson (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Klinisk diabetologi och metabolism
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- Liljebäck, Hanna (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Palm, Fredrik (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Quach, My (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Sandberg, Monica (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Strömberg, Victoria (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Ullsten, Sara (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Carlsson, Per-Ola (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin
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(creator_code:org_t)
- 2016-04-28
- 2016
- English.
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In: Upsala Journal of Medical Sciences. - : Uppsala Medical Society. - 0300-9734 .- 2000-1967. ; 121:2, s. 81-95
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Abstract
Subject headings
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- Pancreatic islets are richly vascularized, and islet blood vessels are uniquely adapted to maintain and support the internal milieu of the islets favoring normal endocrine function. Islet blood flow is normally very high compared with that to the exocrine pancreas and is autonomously regulated through complex interactions between the nervous system, metabolites from insulin secreting beta-cells, endothelium derived mediators, and hormones. The islet blood flow is normally coupled to the needs for insulin release and is usually disturbed during glucose intolerance and overt diabetes. The present review provides a brief background on islet vascular function and especially focuses on available techniques to measure islet blood perfusion. The gold standard for islet blood flow measurements in experimental animals is the microsphere technique, and its advantages and disadvantages will be discussed. In humans there are still no methods to measure islet blood flow selectively, but new developments in radiological techniques hold great hopes for the future.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
Keyword
- Blood flow measurements
- islet blood flow
- microspheres
- pancreatic islets
Publication and Content Type
- ref (subject category)
- for (subject category)
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- By the author/editor
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Jansson, Leif
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Barbu, Andreea
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Bodin, Birgitta
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Drott, Carl Joha ...
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Espes, Daniel
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Gao, Xiang
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show more...
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Grapensparr, Liz ...
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Kallskog, Örjan
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Lau, Joey Börjes ...
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Liljebäck, Hanna
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Palm, Fredrik
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Quach, My
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Sandberg, Monica
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Strömberg, Victo ...
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Ullsten, Sara
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Carlsson, Per-Ol ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and General Practice
- Articles in the publication
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Upsala Journal o ...
- By the university
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Uppsala University