SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Darzentas Nikos)
 

Search: WFRF:(Darzentas Nikos) > An Immunogenetic Si...

An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Bikos, Vasilis (author)
G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.;Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic.
Karypidou, Maria (author)
G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.;CERTH, Inst Appl Biosci, Thessaloniki, Greece.
Stalika, Evangelia (author)
CERTH, Inst Appl Biosci, Thessaloniki, Greece.
show more...
Baliakas, Panagiotis (author)
Uppsala universitet,Experimentell och klinisk onkologi,G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.
Xochelli, Aliki (author)
Uppsala universitet,Experimentell och klinisk onkologi,CERTH, Inst Appl Biosci, Thessaloniki, Greece.
Sutton, Lesley-Ann (author)
Uppsala universitet,Experimentell och klinisk onkologi
Papadopoulos, George (author)
CERTH, Informat Technol Inst, Thessaloniki, Greece.
Agathangelidis, Andreas (author)
Univ Vita Salute San Raffaele, Div Expt Oncol, Milan, Italy.;Univ Vita Salute San Raffaele, Dept Oncohematol, Milan, Italy.;Ist Sci San Raffaele, Milan, Italy.
Papadopoulou, Evdoxia (author)
CERTH, Informat Technol Inst, Thessaloniki, Greece.
Davis, Zadie (author)
Royal Bournemouth Hosp, Dept Haematol, Bournemouth, Dorset, England.
Algara, Patricia (author)
Hosp Virgen Salud, Dept Pathol, Toledo, OH, Spain.
Kanellis, George (author)
Evangelismos Med Ctr, Hematopathol Dept, Athens, Greece.
Traverse-Glehen, Alexandra (author)
Univ Lyon, Hosp Civils Lyon, Dept Pathol & Hematol, Lyon, France.
Mollejo, Manuela (author)
Hosp Virgen Salud, Dept Pathol, Toledo, OH, Spain.
Anagnostopoulos, Achilles (author)
G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.
Ponzoni, Maurilio (author)
Ist Sci San Raffaele, Pathol Unit, I-20132 Milan, Italy.
Gonzalez, David (author)
Inst Canc Res, Sect Haematooncol, London SW3 6JB, England.
Pospisilova, Sarka (author)
Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic.
Matutes, Estella (author)
Inst Canc Res, Sect Haematooncol, London SW3 6JB, England.
Angel Piris, Miguel (author)
Hosp Univ Marques de Valdecilla, Santander, Spain.
Papadaki, Theodora (author)
Evangelismos Med Ctr, Hematopathol Dept, Athens, Greece.
Ghia, Paolo (author)
Univ Vita Salute San Raffaele, Div Expt Oncol, Milan, Italy.;Univ Vita Salute San Raffaele, Dept Oncohematol, Milan, Italy.;Ist Sci San Raffaele, Milan, Italy.
Rosenquist, Richard (author)
Uppsala universitet,Experimentell och klinisk onkologi
Oscier, David (author)
Royal Bournemouth Hosp, Dept Haematol, Bournemouth, Dorset, England.
Darzentas, Nikos (author)
Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic.
Tzovaras, Dimitrios (author)
CERTH, Informat Technol Inst, Thessaloniki, Greece.
Belessi, Chrysoula (author)
Nikea Gen Hosp, Hematol Dept, Piraeus, Greece.
Hadzidimitriou, Anastasia (author)
Uppsala universitet,Experimentell och klinisk onkologi,CERTH, Inst Appl Biosci, Thessaloniki, Greece.
Stamatopoulos, Kostas (author)
Uppsala universitet,Experimentell och klinisk onkologi,G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.;CERTH, Inst Appl Biosci, Thessaloniki, Greece.
show less...
G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.;Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic. G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.;CERTH, Inst Appl Biosci, Thessaloniki, Greece. (creator_code:org_t)
2016
2016
English.
In: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 22:8, s. 2032-2040
Related links:
https://urn.kb.se/re...
show more...
https://doi.org/10.1...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Purpose: Prompted by the extensive biases in the immunoglobulin (IG) gene repertoire of splenic marginal-zone lymphoma (SMZL), supporting antigen selection in SMZL ontogeny, we sought to investigate whether antigen involvement is also relevant post-transformation. Experimental Design: We conducted a large-scale subcloning study of the IG rearrangements of 40 SMZL cases aimed at assessing intraclonal diversification (ID) due to ongoing somatic hypermutation (SHM). Results: ID was identified in 17 of 21 (81%) rearrangements using the immunoglobulin heavy variable (IGHV) 1-2*04 gene versus 8 of 19 (40%) rearrangements utilizing other IGHV genes (P = 0.001). ID was also evident in most analyzed IG light chain gene rearrangements, albeit was more limited compared with IG heavy chains. Identical sequence changes were shared by subclones from different patients utilizing the IGHV1-2*04 gene, confirming restricted ongoing SHM profiles. Non-IGHV1-2*04 cases displayed both a lower number of ongoing SHMs and a lack of shared mutations (per group of cases utilizing the same IGHV gene). Conclusions: These findings support ongoing antigen involvement in a sizable portion of SMZL and further argue that IGHV1-2*04 SMZL may represent a distinct molecular subtype of the disease.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view