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In vivo imaging of ...
In vivo imaging of beta cells with radiotracers : state of the art, prospects and recommendations for development and use
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- Eriksson, Olof (författare)
- Uppsala universitet,Avdelningen för Molekylär Avbildning,Univ Turku, Turku PET Ctr, Turku, Finland.;Abo Akad Univ, Dept Biosci, Turku, Finland.
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- Laughlin, Maren (författare)
- NIDDK, NIH, Bethesda, MD 20892 USA.
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- Brom, Maarten (författare)
- Radboud Univ Nijmegen, Dept Radiol & Nucl Med, Med Ctr, POB 9101, NL-6500 HB Nijmegen, Netherlands.
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- Nuutila, Pirjo (författare)
- Univ Turku, Turku PET Ctr, Turku, Finland.
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- Roden, Michael (författare)
- Univ Dusseldorf, Fac Med, Dept Endocrinol & Diabetol, Dusseldorf, Germany.;Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany.
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- Hwa, Albert (författare)
- JDRF, Discovery Res, New York, NY USA.
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- Bonadonna, Riccardo (författare)
- Univ Parma, Dept Clin & Expt Med, Div Endocrinol, I-43100 Parma, Italy.;AOU Parma, Parma, Italy.
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- Gotthardt, Martin (författare)
- Radboud Univ Nijmegen, Dept Radiol & Nucl Med, Med Ctr, POB 9101, NL-6500 HB Nijmegen, Netherlands.
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(creator_code:org_t)
- 2016-04-19
- 2016
- Engelska.
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 59:7, s. 1340-1349
- Relaterad länk:
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Radiotracer imaging is characterised by high in vivo sensitivity, with a detection limit in the lower picomolar range. Therefore, radiotracers represent a valuable tool for imaging pancreatic beta cells. High demands are made of radiotracers for in vivo imaging of beta cells. Beta cells represent only a small fraction of the volume of the pancreas (usually 1-3%) and are scattered in the tiny islets of Langerhans throughout the organ. In order to be able to measure a beta cell-specific signal, one has to rely on highly specific tracer molecules because current in vivo imaging technologies do not allow the resolution of single islets in humans non-invasively. Currently, a considerable amount of preclinical data are available for several radiotracers and three are under clinical evaluation. We summarise the current status of the evaluation of these tracer molecules and put forward recommendations for their further evaluation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Beta cell
- Beta cell imaging
- Diabetes
- Exendin
- Islet imaging
- Islets of Langerhans
- PET
- Review
- SPECT
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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