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Horizontal Cells, t...
Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease
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- Boije, Henrik (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Fard, Shahrzad Shirazi (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Edqvist, Per-Henrik (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Hallböök, Finn (author)
- Uppsala universitet,Institutionen för neurovetenskap
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(creator_code:org_t)
- 2016-07-19
- 2016
- English.
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In: Frontiers in Neuroanatomy. - : Frontiers Media SA. - 1662-5129. ; 10
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Abstract
Subject headings
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- Thorough investigation of a neuronal population can help reveal key aspects regarding the nervous system and its development. The retinal horizontal cells have several extraordinary features making them particularly interesting for addressing questions regarding fate assignment and subtype specification. In this review we discuss and summarize data concerning the formation and diversity of horizontal cells, how morphology is correlated to molecular markers, and how fate assignment separates the horizontal lineage from the lineages of other retinal cell types. We discuss the novel and unique features of the final cell cycle of horizontal cell progenitors and how they may relate to retinoblastoma carcinogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- cell fate
- cell cycle regulation
- chicken
- development
- DNA damage
- neuronal subtype
- retinoblastoma
- zebrafish
Publication and Content Type
- ref (subject category)
- for (subject category)
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