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Genetic Analysis of...
Genetic Analysis of Physcomitrella patens Identifies ABSCISIC ACID NON-RESPONSIVE, a Regulator of ABA Responses Unique to Basal Land Plants and Required for Desiccation Tolerance
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- Stevenson, Sean R. (author)
- Univ Leeds, Fac Biol Sci, Ctr Plant Sci, Leeds LS2 9JT, W Yorkshire, England.
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- Kamisugi, Yasuko (author)
- Univ Leeds, Fac Biol Sci, Ctr Plant Sci, Leeds LS2 9JT, W Yorkshire, England.
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- Trinh, Chi H. (author)
- Univ Leeds, Astbury Ctr Struct Mol Biol, Fac Biol Sci, Leeds LS2 9JT, W Yorkshire, England.
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- Schmutz, Jeremy (author)
- Joint Genome Inst, Dept Energy, Walnut Creek, CA 94598 USA.;HudsonAlpha Inst Biotechnol, Huntsville, AL 35806 USA.
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- Jenkins, Jerry W. (author)
- Joint Genome Inst, Dept Energy, Walnut Creek, CA 94598 USA.;HudsonAlpha Inst Biotechnol, Huntsville, AL 35806 USA.
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- Grimwood, Jane (author)
- Joint Genome Inst, Dept Energy, Walnut Creek, CA 94598 USA.;HudsonAlpha Inst Biotechnol, Huntsville, AL 35806 USA.
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- Muchero, Wellington (author)
- Oak Ridge Natl Lab, Biosci Div, Oak Ridge, TN 37831 USA.
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- Tuskan, Gerald A. (author)
- Oak Ridge Natl Lab, Biosci Div, Oak Ridge, TN 37831 USA.
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- Rensing, Stefan A. (author)
- Univ Marburg, Plant Cell Biol, D-35043 Marburg, Germany.;Univ Freiburg, BIOSS Ctr Biol Signalling Studies, D-79104 Freiburg, Germany.
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- Lang, Daniel (author)
- Univ Freiburg, BIOSS Ctr Biol Signalling Studies, D-79104 Freiburg, Germany.;Univ Freiburg, Fac Biol, Plant Biotechnol, D-79104 Freiburg, Germany.
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- Reski, Ralf (author)
- Univ Freiburg, BIOSS Ctr Biol Signalling Studies, D-79104 Freiburg, Germany.;Univ Freiburg, Fac Biol, Plant Biotechnol, D-79104 Freiburg, Germany.
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- Melkonian, Michael (author)
- Inst Bot, D-50674 Cologne, Germany.
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- Rothfels, Carl J. (author)
- Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA.
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- Li, Fay-Wei (author)
- Duke Univ, Dept Biol, Durham, NC 27708 USA.
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- Larsson, Anders (author)
- Uppsala universitet,Systematisk biologi
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- Wong, Gane K. -S. (author)
- Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada.;Univ Alberta, Dept Med, Edmonton, AB T6G 2E1, Canada.;BGI Shenzhen, Shenzhen 518083, Peoples R China.
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- Edwards, Thomas A. (author)
- Univ Leeds, Astbury Ctr Struct Mol Biol, Fac Biol Sci, Leeds LS2 9JT, W Yorkshire, England.
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- Cuming, Andrew C. (author)
- Univ Leeds, Fac Biol Sci, Ctr Plant Sci, Leeds LS2 9JT, W Yorkshire, England.
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Univ Leeds, Fac Biol Sci, Ctr Plant Sci, Leeds LS2 9JT, W Yorkshire, England Univ Leeds, Astbury Ctr Struct Mol Biol, Fac Biol Sci, Leeds LS2 9JT, W Yorkshire, England. (creator_code:org_t)
- 2016-05-18
- 2016
- English.
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In: The Plant Cell. - : Oxford University Press (OUP). - 1040-4651 .- 1532-298X. ; 28:6, s. 1310-1327
- Related links:
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Abstract
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- The anatomically simple plants that first colonized land must have acquired molecular and biochemical adaptations to drought stress. Abscisic acid (ABA) coordinates responses leading to desiccation tolerance in all land plants. We identified ABA nonresponsive mutants in the model bryophyte Physcomitrella patens and genotyped a segregating population to map and identify the ABA NON-RESPONSIVE (ANR) gene encoding a modular protein kinase comprising an N-terminal PAS domain, a central EDR domain, and a C-terminal MAPKKK-like domain. anr mutants fail to accumulate dehydration tolerance-associated gene products in response to drought, ABA, or osmotic stress and do not acquire ABA-dependent desiccation tolerance. The crystal structure of the PAS domain, determined to 1.7-angstrom resolution, shows a conserved PAS-fold that dimerizes through a weak dimerization interface. Targeted mutagenesis of a conserved tryptophan residue within the PAS domain generates plants with ABA nonresponsive growth and strongly attenuated ABA-responsive gene expression, whereas deleting this domain retains a fully ABA-responsive phenotype. ANR orthologs are found in early-diverging land plant lineages and aquatic algae but are absent from more recently diverged vascular plants. We propose that ANR genes represent an ancestral adaptation that enabled drought stress survival of the first terrestrial colonizers but were lost during land plant evolution.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Stevenson, Sean ...
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Kamisugi, Yasuko
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Trinh, Chi H.
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Schmutz, Jeremy
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Jenkins, Jerry W ...
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Grimwood, Jane
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Muchero, Welling ...
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Tuskan, Gerald A ...
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Rensing, Stefan ...
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Lang, Daniel
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Reski, Ralf
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Melkonian, Micha ...
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Rothfels, Carl J ...
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Li, Fay-Wei
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Larsson, Anders
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Wong, Gane K. -S ...
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Edwards, Thomas ...
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Cuming, Andrew C ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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The Plant Cell
- By the university
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Uppsala University