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  • Salah, HebaUppsala universitet,Klinisk neurofysiologi,Karolinska Inst, Dept Physiol & Pharmacol, SE-17777 Stockholm, Sweden. (author)

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • American Association for the Advancement of Science (AAAS),2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-303060
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-303060URI
  • https://doi.org/10.1126/scitranslmed.aaf7099DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:134036930URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Ventilation-induced diaphragm dysfunction (VIDD) is a marked decline in diaphragm function in response to mechanical ventilation, which has negative consequences for individual patients' quality of life and for the health care system, but specific treatment strategies are still lacking. We used an experimental intensive care unit (ICU) model, allowing time-resolved studies of diaphragm structure and function in response to long-term mechanical ventilation and the effects of a pharmacological intervention (the chaperone co-inducer BGP-15). The marked loss of diaphragm muscle fiber function in response to mechanical ventilation was caused by post-translational modifications (PTMs) of myosin. In a rat model, 10 days of BGP-15 treatment greatly improved diaphragm muscle fiber function (by about 100%), although it did not reverse diaphragm atrophy. The treatment also provided protection from myosin PTMs associated with HSP72 induction and PARP-1 inhibition, resulting in improvement of mitochondrial function and content. Thus, BGP-15 may offer an intervention strategy for reducing VIDD in mechanically ventilated ICU patients.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Li, MeishanKarolinska Institutet (author)
  • Cacciani, NicolaKarolinska Institutet (author)
  • Gastaldello, StefanoKarolinska Institutet (author)
  • Ogilvie, HannahKarolinska Inst, Dept Physiol & Pharmacol, SE-17777 Stockholm, Sweden. (author)
  • Akkad, HazemKarolinska Institutet (author)
  • Namuduri, Arvind VenkatKarolinska Institutet (author)
  • Morbidoni, ValeriaUniv Padua, Dept Womens & Childrens Hlth, Clin Genet Unit, I-35128 Padua, Italy. (author)
  • Artemenko, Konstantin A.Uppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab(Swepub:uu)konar476 (author)
  • Balogh, GaborHungarian Acad Sci, Biol Res Ctr, Inst Biochem, H-6726 Szeged, Hungary. (author)
  • Martinez-Redondo, VicenteKarolinska Institutet (author)
  • Jannig, PauloKarolinska Institutet (author)
  • Hedström, YvetteKarolinska Institutet (author)
  • Dworkin, BarryKarolinska Inst, Dept Physiol & Pharmacol, SE-17777 Stockholm, Sweden.;Penn State Univ, Dept Neurosci, Hershey, PA 17033 USA. (author)
  • Bergquist, JonasUppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab,Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84112 USA.;Binzhou Med Univ, Precis Med, Yantai 264003, Shandong, Peoples R China.(Swepub:uu)jbe25356 (author)
  • Ruas, JorgeKarolinska Institutet (author)
  • Vigh, LaszloHungarian Acad Sci, Biol Res Ctr, Inst Biochem, H-6726 Szeged, Hungary. (author)
  • Salviati, LeonardoUniv Padua, Dept Womens & Childrens Hlth, Clin Genet Unit, I-35128 Padua, Italy. (author)
  • Larsson, LarsKarolinska Institutet (author)
  • Uppsala universitetKlinisk neurofysiologi (creator_code:org_t)

Related titles

  • In:Science Translational Medicine: American Association for the Advancement of Science (AAAS)8:3501946-62341946-6242

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