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Significant Contrib...
Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis
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- Desbiens, Louisane (författare)
- Univ Sherbrooke, Sch Med, Dept Pharmacol, 3001 12th Ave North, Sherbrooke, PQ J1H 5N4, Canada.
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- Lapointe, Catherine (författare)
- Univ Sherbrooke, Sch Med, Dept Pharmacol, 3001 12th Ave North, Sherbrooke, PQ J1H 5N4, Canada.
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- Gharagozloo, Marjan (författare)
- Univ Sherbrooke, Sch Med, Dept Pediat, Program Immunol & Allergol, 3001 12th Ave North, Sherbrooke, PQ J1H 5N4, Canada.
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- Mahmoud, Shaimaa (författare)
- Univ Sherbrooke, Sch Med, Dept Pediat, Program Immunol & Allergol, 3001 12th Ave North, Sherbrooke, PQ J1H 5N4, Canada.
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- Pejler, Gunnar (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, POB 7070, S-75007 Uppsala, Sweden.,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB),Uppsala University
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- Gris, Denis (författare)
- Univ Sherbrooke, Sch Med, Dept Pediat, Program Immunol & Allergol, 3001 12th Ave North, Sherbrooke, PQ J1H 5N4, Canada.
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- D'Orleans-Juste, Pedro (författare)
- Univ Sherbrooke, Sch Med, Dept Pharmacol, 3001 12th Ave North, Sherbrooke, PQ J1H 5N4, Canada.
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Univ Sherbrooke, Sch Med, Dept Pharmacol, 3001 12th Ave North, Sherbrooke, PQ J1H 5N4, Canada Univ Sherbrooke, Sch Med, Dept Pediat, Program Immunol & Allergol, 3001 12th Ave North, Sherbrooke, PQ J1H 5N4, Canada. (creator_code:org_t)
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- Hindawi Limited, 2016
- 2016
- Engelska.
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Ingår i: Mediators of Inflammation. - : Hindawi Limited. - 0962-9351 .- 1466-1861.
- Relaterad länk:
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Experimental autoimmune encephalomyelitis (EAE) is a mouse model that reproduces cardinal signs of clinical, histopathological, and immunological features found in Multiple Sclerosis (MS). Mast cells are suggested to be involved in the main inflammatory phases occurring during EAE development, possibly by secreting several autacoids and proteases. Among the latter, the chymase mouse mast cell protease 4 (mMCP-4) can contribute to the inflammatory response by producing endothelin-1 (ET-1). The aim of this study was to determine the impact of mMCP-4 on acute inflammatory stages in EAE. C57BL/6 wild type (WT) or mMCP-4 knockout (KO) mice were immunized with MOG(35-55) plus complete Freund's adjuvant followed by pertussis toxin. Immunized WT mice presented an initial acute phase characterized by progressive increases in clinical score, which were significantly reduced in mMCP-4 KO mice. In addition, higher levels of spinal myelin were found in mMCP-4 KO as compared with WT mice. Finally, whereas EAE triggered significant increases in brain levels of mMCP-4 mRNA and immunoreactive ET-1 in WT mice, the latter peptide was reduced to basal levels in mMCP-4 KO congeners. Together, the present study supports a role form MCP-4 in the early inflammatory phases of the disease in a mouse model of MS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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